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5OR5	NMR structure of the complex formed by an engineered region 2 of sigmaE in complex with GTAAAA Descriptor: DNA (5'-D(*GP*TP*AP*AP*AP*A)-3'), ECF RNA polymerase sigma-E factor,ECF RNA polymerase sigma factor SigW,ECF RNA polymerase sigma-E factor Authors: Campagne, S, Vorholt, J.A, Allain, F.H. Deposit date: 2017-08-15 Release date: 2018-06-27 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Engineered promoter selectivity of an ECF sigma factor Not published
1H3L	N-terminal fragment of SigR from Streptomyces coelicolor Descriptor: RNA POLYMERASE SIGMA FACTOR Authors: Li, W, Stevenson, C.E.M, Burton, N, Jakimowicz, P, Paget, M.S.B, Buttner, M.J, Lawson, D.M, Kleanthous, C. Deposit date: 2002-09-10 Release date: 2002-10-03 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.375 Å) Cite: Identification and Structure of the Anti-Sigma Factor-Binding Domain of the Disulfide-Stress Regulated Sigma Factor Sigma(R) from Streptomyces Coelicolor J.Mol.Biol., 323, 2002
2O7G	Crystal structure of the Pribnow Box recognition region of SigC from Mycobacterium tuberculosis Descriptor: Probable RNA polymerase sigma-C factor, SULFATE ION Authors: Thakur, K.G, Joshi, A.M, Gopal, B. Deposit date: 2006-12-11 Release date: 2006-12-26 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structural and biophysical studies on two promoter recognition domains of the extra-cytoplasmic function sigma factor sigma(C) from Mycobacterium tuberculosis. J.Biol.Chem., 282, 2007
8B3Z	SigE N-terminal Domain Descriptor: RNA polymerase sigma factor Authors: Evans, N.J, Isaacson, R.L, Collins, K.M, Camp, A.H. Deposit date: 2022-09-18 Release date: 2023-08-23 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.38 Å) Cite: Structural Analysis of Bacillus subtilis Sigma Factors. Microorganisms, 11, 2023
3MZY	The Crystal Structure of the RNA polymerase sigma-H factor from Fusobacterium nucleatum to 2.5A Descriptor: RNA polymerase sigma-H factor Authors: Stein, A.J, Chhor, G, Clancy, S, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) Deposit date: 2010-05-13 Release date: 2010-06-02 Last modified: 2017-11-08 Method: X-RAY DIFFRACTION (2.5 Å) Cite: The Crystal Structure of the RNA polymerase sigma-H factor from Fusobacterium nucleatum to 2.5A To be Published
4LUP	Crystal structure of the complex formed by region of E. coli sigmaE bound to its -10 element non template strand Descriptor: 1,2-ETHANEDIOL, RNA polymerase sigma factor, region 2 of sigmaE of E. coli Authors: Campagne, S, Marsh, M.E, Vorholt, J.A.V, Allain, F.H.-T, Capitani, G. Deposit date: 2013-07-25 Release date: 2014-02-19 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.2 Å) Cite: Structural basis for -10 promoter element melting by environmentally induced sigma factors. Nat.Struct.Mol.Biol., 21, 2014
4CXF	Structure of CnrH in complex with the cytosolic domain of CnrY Descriptor: CHLORIDE ION, CNRY, RNA POLYMERASE SIGMA FACTOR CNRH, ... Authors: Maillard, A.P, Girard, E, Ziani, W, Petit-Hartlein, I, Kahn, R, Coves, J. Deposit date: 2014-04-07 Release date: 2014-04-30 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.75 Å) Cite: The Crystal Structure of the Anti-Sigma Factor Cnry in Complex with the Sigma Factor Cnrh Shows a New Structural Class of Anti- Sigma Factors Targeting Extracytoplasmic-Function Sigma Factors. J.Mol.Biol., 426, 2014
2Z2S	Crystal Structure of Rhodobacter sphaeroides SigE in complex with the anti-sigma ChrR Descriptor: Anti-Sigma factor ChrR, transcriptional activator ChrR, RpoE, ... Authors: Darst, S.A, Campbell, E.A. Deposit date: 2007-05-26 Release date: 2008-02-05 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.7 Å) Cite: A conserved structural module regulates transcriptional responses to diverse stress signals in bacteria. Mol.Cell, 27, 2007
2Q1Z	Crystal Structure of Rhodobacter sphaeroides SigE in complex with the anti-sigma ChrR Descriptor: Anti-Sigma factor ChrR, transcriptional activator ChrR, RpoE, ... Authors: Campbell, E.A, Darst, S.A. Deposit date: 2007-05-25 Release date: 2007-09-18 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.4 Å) Cite: A conserved structural module regulates transcriptional responses to diverse stress signals in bacteria. Mol.Cell, 27, 2007
5XE7	Crystal structure of Mycobacterium tuberculosis extracytoplasmic function sigma factor SigJ Descriptor: ECF RNA polymerase sigma factor SigJ Authors: Goutam, K, Gopal, B. Deposit date: 2017-04-01 Release date: 2017-07-19 Last modified: 2017-10-04 Method: X-RAY DIFFRACTION (2.162 Å) Cite: The fused SnoaL_2 domain in the Mycobacterium tuberculosis sigma factor sigma J modulates promoter recognition Nucleic Acids Res., 45, 2017
7QH5	The crystal structure of the sigma factor SigG1 from Streptomyces tsukubaensis NRRL18488 Descriptor: GLYCEROL, RNA polymerase sigma factor Authors: Lourenco, F, Leite, J.P, Gales, L. Deposit date: 2021-12-10 Release date: 2022-12-21 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal structures of Streptomyces tsukubaensis sigma factor SigG1 and anti-sigma RsfG. J.Struct.Biol., 215, 2023
4NQW	Structure of Mycobacterium tuberculosis extracytoplasmic function sigma factor SigK in complex with the cytosolic domain of its cognate anti-sigma factor RskA Descriptor: Anti-sigma-K factor RskA, CADMIUM ION, ECF RNA polymerase sigma factor SigK Authors: Shukla, J.K, Gopal, B. Deposit date: 2013-11-25 Release date: 2014-01-22 Last modified: 2014-04-16 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural basis for the redox sensitivity of the Mycobacterium tuberculosis SigK-RskA sigma-anti-sigma complex Acta Crystallogr.,Sect.D, 70, 2014
7LQ4	Rr (RsiG)2-(c-di-GMP)2-WhiG complex Descriptor: 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), RsiG, WhiG Authors: Schumacher, M.A, Brennan, R.G. Deposit date: 2021-02-12 Release date: 2021-07-14 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Evolution of a sigma-(c-di-GMP)-anti-sigma switch. Proc.Natl.Acad.Sci.USA, 118, 2021
6DXO	1.8 A structure of RsbN-BldN complex. Descriptor: BldN, RNA polymerase ECF-subfamily sigma factor Authors: Schumacher, M.A. Deposit date: 2018-06-29 Release date: 2018-07-11 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.8 Å) Cite: The crystal structure of the RsbN-sigma BldN complex from Streptomyces venezuelae defines a new structural class of anti-sigma factor. Nucleic Acids Res., 46, 2018
5UXX	Co-crystal structure of the sigma factor RpoE in complex with the anti-sigma factor NepR from Bartonella quintana Descriptor: Anti-sigma factor NepR, RNA polymerase sigma factor, SULFATE ION Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2017-02-23 Release date: 2018-02-28 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Co-crystal structure of the sigma factor RpoE in complex with the anti-sigma factor NepR from Bartonella quintana to be published
5WUQ	Crystal structure of SigW in complex with its anti-sigma RsiW, a zinc binding form Descriptor: Anti-sigma-W factor RsiW, ECF RNA polymerase sigma factor SigW, ZINC ION Authors: Devkota, S.R, Kwon, E, Ha, S.C, Kim, D.Y. Deposit date: 2016-12-20 Release date: 2017-03-29 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structural insights into the regulation of Bacillus subtilis SigW activity by anti-sigma RsiW PLoS ONE, 12, 2017
5WUR	Crystal structure of SigW in complex with its anti-sigma RsiW, an oxdized form Descriptor: Anti-sigma-W factor RsiW, ECF RNA polymerase sigma factor SigW Authors: Devkota, S.R, Kwon, E, Ha, S.C, Kim, D.Y. Deposit date: 2016-12-20 Release date: 2017-03-29 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structural insights into the regulation of Bacillus subtilis SigW activity by anti-sigma RsiW PLoS ONE, 12, 2017
8Z6G	the AlgU-MucAcyto complex structure in Pseudomonas aeruginosa Descriptor: Anti sigma-E RseA, N-terminal domain protein, RNA polymerase sigma factor Authors: Li, T, Wang, Y.Z, Bao, R. Deposit date: 2024-04-19 Release date: 2024-05-08 Method: X-RAY DIFFRACTION (2.10109687 Å) Cite: the AlgU-MucAcyto complex structure in Pseudomonas aeruginosa To Be Published
7RWI	Mycobacterium tuberculosis RNA polymerase sigma L holoenzyme open promoter complex containing TNP-2198 Descriptor: (3aM,9S,10bP,14S,15R,16S,17R,18R,19R,20S,21S,25R)-6,18,20-trihydroxy-14-methoxy-7,9,15,17,19,21,25-heptamethyl-1'-[2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl]-5,10,26-trioxo-3,5,9,10-tetrahydrospiro[9,4-(epoxypentadecanoimino)furo[2',3':7,8]naphtho[1,2-d]imidazole-2,4'-piperidin]-16-yl acetate, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Molodtsov, V, Ebright, R.H. Deposit date: 2021-08-19 Release date: 2022-03-02 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.7 Å) Cite: Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. J.Med.Chem., 65, 2022
4MQ9	Crystal structure of Thermus thermophilus RNA polymerase holoenzyme in complex with GE23077 Descriptor: (2Z)-2-methylbut-2-enoic acid, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Ho, M.X, Arnold, E, Ebright, R.H, Zhang, Y, Tuske, S. Deposit date: 2013-09-16 Release date: 2014-05-07 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (3.35 Å) Cite: GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides. Elife, 3, 2014
3UGP	Crystal structure of RNA-polymerase sigma subunit domain 2 complexed with -10 promoter element ssDNA oligo (TATAAT) Descriptor: 5'-D(*TP*GP*TP*AP*TP*AP*AP*TP*GP*GP*G)-3', POTASSIUM ION, RNA polymerase sigma factor Authors: Feklistov, A, Darst, S.A. Deposit date: 2011-11-02 Release date: 2011-12-07 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.697 Å) Cite: Structural basis for promoter-10 element recognition by the bacterial RNA polymerase sigma subunit. Cell(Cambridge,Mass.), 147, 2011
7ZF2	Protomeric substructure from an octameric assembly of M. tuberculosis RNA polymerase in complex with sigma-b initiation factor Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Trapani, S, Bron, P, Lai Kee Him, J, Brodolin, K, Morichaud, Z, Vishwakarma, R. Deposit date: 2022-03-31 Release date: 2023-02-08 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (3.86 Å) Cite: Structural basis of the mycobacterial stress-response RNA polymerase auto-inhibition via oligomerization. Nat Commun, 14, 2023
7P5X	Mycobacterial RNAP with transcriptional activator PafBC Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Mueller, A.U, Kummer, E, Schilling, C.M, Ban, N, Weber-Ban, E. Deposit date: 2021-07-15 Release date: 2021-12-22 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Transcriptional control of mycobacterial DNA damage response by sigma adaptation. Sci Adv, 7, 2021
1OR7	Crystal Structure of Escherichia coli sigmaE with the Cytoplasmic Domain of its Anti-sigma RseA Descriptor: RNA polymerase sigma-E factor, Sigma-E factor negative regulatory protein Authors: Campbell, E.A, Tupy, J.L, Gruber, T.M, Wang, S, Sharp, M.M, Gross, C.A, Darst, S.A. Deposit date: 2003-03-12 Release date: 2003-04-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structure of Escherichia coli sigmaE with the cytoplasmic domain of its anti-sigma RseA. Mol.Cell, 11, 2003
4X8K	Mycobacterium tuberculosis RbpA-SID in complex with SigmaA domain 2 Descriptor: 1,2-ETHANEDIOL, RNA polymerase sigma factor SigA, RNA polymerase-binding protein RbpA, ... Authors: Hubin, E.A, Flack, J.E, Tabib-Salazar, A, Paget, M.S, Darst, S.A, Campbell, E.A. Deposit date: 2014-12-10 Release date: 2015-06-03 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.202 Å) Cite: Structural, functional, and genetic analyses of the actinobacterial transcription factor RbpA. Proc.Natl.Acad.Sci.USA, 112, 2015

 

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