4UUV
 
 | | Structure of the DNA binding ETS domain of human ETV4 in complex with DNA | | Descriptor: | 5'-D(*AP*CP*CP*GP*GP*AP*AP*GP*TP*GP)-3', 5'-D(*AP*CP*TP*TP*CP*CP*GP*GP*TP*CP)-3', ETS TRANSLOCATION VARIANT 4 | | Authors: | Newman, J.A, Cooper, C.D.O, Kopec, J, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Gileadi, O. | | Deposit date: | 2014-07-31 | | Release date: | 2014-08-13 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structures of the Ets Domains of Transcription Factors Etv1, Etv4, Etv5 and Fev: Determinants of DNA Binding and Redox Regulation by Disulfide Bond Formation.
J.Biol.Chem., 290, 2015
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4UNO
 | | Crystal structure of the ETS domain of human ETV5 in complex with DNA | | Descriptor: | 5'-D(*AP*CP*CP*GP*GP*AP*AP*GP*TP*GP)-3', 5'-D(*AP*CP*TP*TP*CP*CP*GP*GP*TP*CP)-3', CALCIUM ION, ... | | Authors: | Newman, J.A, Aitkenhead, H, Cooper, C.D.O, Pinkas, D.M, Shrestha, L, Burgess-Brown, N, Kopec, J, Fitzpatrick, F, Tallant, C, von Delft, F, Arrowsmith, C.H, Bountra, C, Edwards, A, Gileadi, O. | | Deposit date: | 2014-05-29 | | Release date: | 2014-06-11 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Structures of the Ets Domains of Transcription Factors Etv1, Etv4, Etv5 and Fev: Determinants of DNA Binding and Redox Regulation by Disulfide Bond Formation.
J.Biol.Chem., 290, 2015
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2YPR
 | | Crystal structure of the DNA binding ETS domain of human protein FEV | | Descriptor: | GLYCEROL, PROTEIN FEV | | Authors: | Allerston, C.K, Cooper, C, Vollmar, M, Krojer, T, von Delft, F, Weigelt, J, Arrowsmith, C.H, Bountra, C, Edwards, A, Gileadi, O. | | Deposit date: | 2012-10-31 | | Release date: | 2013-01-16 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.64 Å) | | Cite: | Structures of the Ets Domains of Transcription Factors Etv1, Etv4, Etv5 and Fev: Determinants of DNA Binding and Redox Regulation by Disulfide Bond Formation.
J.Biol.Chem., 290, 2015
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2DAO
 | | Solution structure of ETS domain Transcriptional factor ETV6 protein | | Descriptor: | Transcription factor ETV6 | | Authors: | Niraula, T.N, Sasagawa, A, Tomizawa, T, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2005-12-14 | | Release date: | 2006-12-12 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution structure of ETS domain Transcriptional factor ETV6 protein
To be Published
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3RI4
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5ILU
 | | Autoinhibited ETV4 | | Descriptor: | ETS translocation variant 4 | | Authors: | Whitby, F.G, Currie, S.L. | | Deposit date: | 2016-03-04 | | Release date: | 2017-02-22 | | Last modified: | 2019-12-25 | | Method: | X-RAY DIFFRACTION (1.101 Å) | | Cite: | Structured and disordered regions cooperatively mediate DNA-binding autoinhibition of ETS factors ETV1, ETV4 and ETV5.
Nucleic Acids Res., 45, 2017
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8SP1
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8T9U
 | | Human PU.1 ETS-domain (165-270) in complex with d(AATAAGCGIAAGTGGG) | | Descriptor: | DNA (5'-D(*AP*AP*TP*AP*AP*GP*CP*GP*IP*AP*AP*GP*TP*GP*GP*G)-3'), DNA (5'-D(*TP*CP*CP*CP*AP*CP*TP*TP*CP*CP*GP*CP*TP*TP*AP*T)-3'), SODIUM ION, ... | | Authors: | Terrell, J.R, Poon, G.M.K. | | Deposit date: | 2023-06-26 | | Release date: | 2023-11-29 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.47 Å) | | Cite: | Dissection of integrated readout reveals the structural thermodynamics of DNA selection by transcription factors.
Structure, 32, 2024
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7JSA
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7JSL
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5JVT
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1PUE
 | | PU.1 ETS DOMAIN-DNA COMPLEX | | Descriptor: | DNA (5'-D(*AP*AP*AP*AP*AP*GP*GP*GP*GP*AP*AP*GP*TP*GP*GP*G)-3'), DNA (5'-D(*TP*CP*CP*CP*AP*CP*TP*TP*CP*CP*CP*CP*TP*TP*TP*T)-3'), PROTEIN (TRANSCRIPTION FACTOR PU.1 (TF PU.1)) | | Authors: | Kodandapani, R, Pio, F, Ni, C.Z, Piccialli, G, Klemsz, M, McKercher, S, Maki, R.A, Ely, K.R. | | Deposit date: | 1996-07-08 | | Release date: | 1997-02-12 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | A new pattern for helix-turn-helix recognition revealed by the PU.1 ETS-domain-DNA complex.
Nature, 380, 1996
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8SMJ
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8SMH
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3JTG
 | | Crystal structure of mouse Elf3 C-terminal DNA-binding domain in complex with type II TGF-beta receptor promoter DNA | | Descriptor: | DNA (5'-D(*CP*AP*AP*AP*CP*AP*GP*GP*AP*AP*AP*CP*TP*CP*CP*T)-3'), DNA (5'-D(*GP*AP*GP*GP*AP*GP*TP*TP*TP*CP*CP*TP*GP*TP*TP*T)-3'), ETS-related transcription factor Elf-3 | | Authors: | Tahirov, T.H, Babayeva, N.D, Agarkar, V.B, Rizzino, A. | | Deposit date: | 2009-09-11 | | Release date: | 2010-01-12 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal structure of mouse Elf3 C-terminal DNA-binding domain in complex with type II TGF-beta receptor promoter DNA.
J.Mol.Biol., 397, 2010
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1WWX
 | | Solution structure of the ETS-domain of the Ets domain transcription factor | | Descriptor: | E74-like factor 5 ESE-2b | | Authors: | Goroncy, A, Kigawa, T, Koshiba, S, Kobayashi, N, Tochio, N, Inoue, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2005-01-18 | | Release date: | 2005-07-18 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the ETS-domain of the Ets domain transcription factor
To be Published
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6DA1
 | | ETS1 in complex with synthetic SRR mimic | | Descriptor: | Protein C-ets-1, SULFATE ION, serine-rich region (SRR) peptide | | Authors: | Perez-Borrajero, C, Okon, M, Lin, C.S, Scheu, K, Murphy, M.E.P, Graves, B.J, McIntosh, L.P. | | Deposit date: | 2018-05-01 | | Release date: | 2019-01-16 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.000127 Å) | | Cite: | The Biophysical Basis for Phosphorylation-Enhanced DNA-Binding Autoinhibition of the ETS1 Transcription Factor.
J. Mol. Biol., 431, 2019
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1R36
 | | NMR-based structure of autoinhibited murine Ets-1 deltaN301 | | Descriptor: | C-ets-1 protein | | Authors: | Lee, G.M, Donaldson, L.W, Pufall, M.A, Kang, H.-S, Pot, I, Graves, B.J, McIntosh, L.P. | | Deposit date: | 2003-09-30 | | Release date: | 2004-11-09 | | Last modified: | 2024-05-08 | | Method: | SOLUTION NMR | | Cite: | The Structural and Dynamic Basis of Ets-1 DNA Binding Autoinhibition
J.Biol.Chem., 280, 2005
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6DAT
 | | ETS1 in complex with synthetic SRR mimic | | Descriptor: | Protein C-ets-1, SULFATE ION, serine-rich region (SRR) peptide | | Authors: | Perez-Borrajero, C, Okon, M, Lin, C.S, Scheu, K, Murphy, M.E.P, Graves, B.J, McIntosh, L.P. | | Deposit date: | 2018-05-02 | | Release date: | 2019-01-16 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.35002637 Å) | | Cite: | The Biophysical Basis for Phosphorylation-Enhanced DNA-Binding Autoinhibition of the ETS1 Transcription Factor.
J. Mol. Biol., 431, 2019
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2STW
 | | SOLUTION NMR STRUCTURE OF THE HUMAN ETS1/DNA COMPLEX, RESTRAINED REGULARIZED MEAN STRUCTURE | | Descriptor: | DNA (5'-D(*TP*CP*GP*AP*AP*CP*TP*TP*CP*CP*GP*GP*CP*TP*CP*GP*A)-3'), DNA (5'-D(*TP*CP*GP*AP*GP*CP*CP*GP*GP*AP*AP*GP*TP*TP*CP*GP*A)-3'), ETS1 | | Authors: | Clore, G.M, Werner, M.H, Gronenborn, A.M. | | Deposit date: | 1996-08-05 | | Release date: | 1997-03-12 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Correction of the NMR structure of the ETS1/DNA complex.
J.Biomol.NMR, 10, 1997
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2STT
 | | SOLUTION NMR STRUCTURE OF THE HUMAN ETS1/DNA COMPLEX, 25 STRUCTURES | | Descriptor: | DNA (5'-D(*TP*CP*GP*AP*AP*CP*TP*TP*CP*CP*GP*GP*CP*TP*CP*GP*A)-3'), DNA (5'-D(*TP*CP*GP*AP*GP*CP*CP*GP*GP*AP*AP*GP*TP*TP*CP*GP*A)-3'), ETS1 | | Authors: | Clore, G.M, Werner, M.H, Gronenborn, A.M. | | Deposit date: | 1996-08-05 | | Release date: | 1997-03-12 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Correction of the NMR structure of the ETS1/DNA complex.
J.Biomol.NMR, 10, 1997
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3MFK
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1YO5
 | | Analysis of the 2.0A crystal structure of the protein-DNA complex of human PDEF Ets domain bound to the prostate specific antigen regulatory site | | Descriptor: | Enhancer site of Prostate Specific Antigen Promoter Region, SAM pointed domain containing ets transcription factor | | Authors: | Wang, Y, Feng, L, Said, M, Balderman, S, Fayazi, Z, Liu, Y, Ghosh, D, Gulick, A.M. | | Deposit date: | 2005-01-26 | | Release date: | 2005-05-17 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Analysis of the 2.0 A Crystal Structure of the Protein-DNA Complex of the Human PDEF Ets Domain Bound to the Prostate Specific Antigen Regulatory Site
Biochemistry, 44, 2005
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1BC7
 | | SERUM RESPONSE FACTOR ACCESSORY PROTEIN 1A (SAP-1)/DNA COMPLEX | | Descriptor: | DNA (5'-D(*CP*AP*CP*AP*TP*CP*CP*TP*GP*TP*C)-3'), DNA (5'-D(*GP*AP*CP*AP*GP*GP*AP*TP*GP*TP*G)-3'), PROTEIN (ETS-DOMAIN PROTEIN) | | Authors: | Mo, Y, Vaessen, B, Johnston, K, Marmorstein, R. | | Deposit date: | 1998-05-05 | | Release date: | 1999-01-21 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.01 Å) | | Cite: | Structures of SAP-1 bound to DNA targets from the E74 and c-fos promoters: insights into DNA sequence discrimination by Ets proteins.
Mol.Cell, 2, 1998
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1BC8
 | | STRUCTURES OF SAP-1 BOUND TO DNA SEQUENCES FROM THE E74 AND C-FOS PROMOTERS PROVIDE INSIGHTS INTO HOW ETS PROTEINS DISCRIMINATE BETWEEN RELATED DNA TARGETS | | Descriptor: | DNA (5'-D(*AP*AP*CP*TP*TP*CP*CP*GP*GP*T)-3'), DNA (5'-D(*TP*AP*CP*CP*GP*GP*AP*AP*GP*T)-3'), PROTEIN (SAP-1 ETS DOMAIN), ... | | Authors: | Mo, Y, Vaessen, B, Johnston, K, Marmorstein, R. | | Deposit date: | 1998-05-05 | | Release date: | 1998-12-01 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.93 Å) | | Cite: | Structures of SAP-1 bound to DNA targets from the E74 and c-fos promoters: insights into DNA sequence discrimination by Ets proteins.
Mol.Cell, 2, 1998
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