2MBH
| NMR structure of EKLF(22-40)/Ubiquitin Complex | Descriptor: | Krueppel-like factor 1, Ubiquitin | Authors: | Raiola, L, Omichinski, J.G. | Deposit date: | 2013-07-31 | Release date: | 2013-10-09 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structural Characterization of a Noncovalent Complex between Ubiquitin and the Transactivation Domain of the Erythroid-Specific Factor EKLF. Structure, 21, 2013
|
|
2MCN
| Distinct ubiquitin binding modes exhibited by SH3 domains: molecular determinants and functional implications | Descriptor: | CD2-associated protein, Ubiquitin | Authors: | Ortega-Roldan, J, Salmon, L, Azuaga, A, Blackledge, M, Van Nuland, N. | Deposit date: | 2013-08-22 | Release date: | 2014-02-05 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Distinct ubiquitin binding modes exhibited by SH3 domains: molecular determinants and functional implications. Plos One, 8, 2013
|
|
2MBB
| Solution Structure of the human Polymerase iota UBM1-Ubiquitin Complex | Descriptor: | Immunoglobulin G-binding protein G/DNA polymerase iota fusion protein, Polyubiquitin-B | Authors: | Wang, S, Zhou, P. | Deposit date: | 2013-07-29 | Release date: | 2014-06-04 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Sparsely-sampled, high-resolution 4-D omit spectra for detection and assignment of intermolecular NOEs of protein complexes. J.Biomol.Nmr, 59, 2014
|
|
2MA9
| HIV-1 Vif SOCS-box and Elongin BC solution structure | Descriptor: | Transcription elongation factor B polypeptide 1, Transcription elongation factor B polypeptide 2, Virion infectivity factor | Authors: | Lu, Z, Bergeron, J.R, Atkinson, R.A, Schaller, T, Veselkov, D.A, Oregioni, A, Yang, Y, Matthews, S.J, Malim, M.H, Sanderson, M.R. | Deposit date: | 2013-07-01 | Release date: | 2013-12-11 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Insight into the HIV-1 Vif SOCS-box-ElonginBC interaction. OPEN BIOLOGY, 3, 2013
|
|
2LXC
| |
2N3V
| |
2NBV
| |
2N3W
| |
2N3U
| |
2N9P
| Solution structure of RNF126 N-terminal zinc finger domain in complex with BAG6 Ubiquitin-like domain | Descriptor: | E3 ubiquitin-protein ligase RNF126, Large proline-rich protein BAG6, ZINC ION | Authors: | Martinez-Lumbreras, S, Krysztofinska, E.M, Thapaliya, A, Isaacson, R.L. | Deposit date: | 2015-12-01 | Release date: | 2016-05-25 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structural and functional insights into the E3 ligase, RNF126. Sci Rep, 6, 2016
|
|
2NBW
| Solution structure of the Rpn1 T1 site with the Rad23 UBL domain | Descriptor: | 26S proteasome regulatory subunit RPN1, UV excision repair protein RAD23 | Authors: | Chen, X, Walters, K.J. | Deposit date: | 2016-03-14 | Release date: | 2016-07-20 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Structures of Rpn1 T1:Rad23 and hRpn13:hPLIC2 Reveal Distinct Binding Mechanisms between Substrate Receptors and Shuttle Factors of the Proteasome. Structure, 24, 2016
|
|
2MRO
| |
2MUR
| |
2LVO
| Structure of the gp78CUE domain bound to monubiquitin | Descriptor: | E3 ubiquitin-protein ligase AMFR, Ubiquitin | Authors: | Liu, S, Chen, Y, Huang, T, Tarasov, S.G, King, A, Li, J, Weissman, A.M, Byrd, R.A, Das, R. | Deposit date: | 2012-07-09 | Release date: | 2012-11-21 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Promiscuous Interactions of gp78 E3 Ligase CUE Domain with Polyubiquitin Chains. Structure, 20, 2012
|
|
7YUI
| |
8R1G
| Dimeric ternary structure of E6AP-E6-p53 | Descriptor: | Cellular tumor antigen p53, Ubiquitin-like protein SMT3,Protein E6, Ubiquitin-protein ligase E3A, ... | Authors: | Sandate, C.R, Chakrabory, D, Kater, L, Kempf, G, Thoma, N.H. | Deposit date: | 2023-11-01 | Release date: | 2023-12-06 | Method: | ELECTRON MICROSCOPY (3.99 Å) | Cite: | Monomeric E6AP-E6-p53 ternary complex To Be Published
|
|
8R1F
| Monomeric E6AP-E6-p53 ternary complex | Descriptor: | Cellular tumor antigen p53, Ubiquitin-like protein SMT3,Protein E6, Ubiquitin-protein ligase E3A, ... | Authors: | Sandate, C.R, Chakraborty, D, Kater, L, Kempf, G, Thoma, N.H. | Deposit date: | 2023-11-01 | Release date: | 2023-12-06 | Method: | ELECTRON MICROSCOPY (3.67 Å) | Cite: | Monomeric E6AP-E6-p53 ternary complex To Be Published
|
|
7ZNT
| CRYSTAL STRUCTURE OF AT7 IN COMPLEX WITH THE SECOND BROMODOMAIN OF HUMAN BRD4 AND PVHL:ELONGINC:ELONGINB | Descriptor: | (2~{S},4~{R})-1-[(2~{R})-3-[6-[2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]ethanoylamino]hexylsulfanyl]-2-[(1-fluoranylcyclopropyl)carbonylamino]-3-methyl-butanoyl]-~{N}-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Bromodomain-containing protein 4, Elongin-B, ... | Authors: | Hughes, S.J, Casement, R, Ciulli, A. | Deposit date: | 2022-04-22 | Release date: | 2022-09-14 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Functional E3 ligase hotspots and resistance mechanisms to small-molecule degraders. Nat.Chem.Biol., 19, 2023
|
|
7ZH3
| |
7ZH4
| USP1 bound to ML323 and ubiquitin conjugated to FANCD2 (focused refinement) | Descriptor: | 5-methyl-2-(2-propan-2-ylphenyl)-~{N}-[[4-(1,2,3-triazol-1-yl)phenyl]methyl]pyrimidin-4-amine, Ubiquitin carboxyl-terminal hydrolase 1, Ubiquitin-60S ribosomal protein L40, ... | Authors: | Rennie, M.L, Walden, H. | Deposit date: | 2022-04-05 | Release date: | 2022-10-12 | Method: | ELECTRON MICROSCOPY (2.49 Å) | Cite: | Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site. Sci Adv, 8, 2022
|
|
8A9J
| |
8A9K
| Cryo-EM structure of USP1-UAF1 bound to FANCI and mono-ubiquitinated FANCD2 with ML323 (consensus reconstruction) | Descriptor: | 5-methyl-2-(2-propan-2-ylphenyl)-~{N}-[[4-(1,2,3-triazol-1-yl)phenyl]methyl]pyrimidin-4-amine, DNA (61-MER), Fanconi anemia group D2 protein, ... | Authors: | Rennie, M.L, Walden, H. | Deposit date: | 2022-06-28 | Release date: | 2022-10-12 | Last modified: | 2023-03-01 | Method: | ELECTRON MICROSCOPY (2.85 Å) | Cite: | Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site. Sci Adv, 8, 2022
|
|
8SH2
| KLHDC2 in complex with EloB and EloC | Descriptor: | Elongin-B, Elongin-C, Kelch domain-containing protein 2 | Authors: | Digianantonio, K.M, Bekes, M. | Deposit date: | 2023-04-13 | Release date: | 2024-01-03 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (3.74 Å) | Cite: | Co-opting the E3 ligase KLHDC2 for targeted protein degradation by small molecules. Nat.Struct.Mol.Biol., 31, 2024
|
|
8T2D
| Ubiquitin variant i53:Mutant T12Y.T14E.L67R with 53BP1 Tudor domain | Descriptor: | Tumor protein p53 binding protein 1, Ubiquitin variant i53 | Authors: | Partridge, J.R, Holden, J.K, Wibowo, A.S, Mulichak, A. | Deposit date: | 2023-06-05 | Release date: | 2024-03-27 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.751 Å) | Cite: | Functional screening in human HSPCs identifies optimized protein-based enhancers of Homology Directed Repair. Nat Commun, 15, 2024
|
|
7ZWL
| Crystal structure of human STING in complex with 3',3'-c-di-(2'F,2'dAMP) | Descriptor: | 9-[(1~{R},6~{R},8~{R},9~{S},10~{R},15~{R},17~{R},18~{S})-17-(6-aminopurin-9-yl)-9,18-bis(fluoranyl)-3,12-bis(oxidanyl)-3,12-bis(oxidanylidene)-2,4,11,13-tetraoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.3.0.0^{6,10}]octadecan-8-yl]purin-6-amine, Stimulator of interferon protein, Ubiquitin-like protein SMT3 | Authors: | Klima, M, Smola, M, Boura, E. | Deposit date: | 2022-05-19 | Release date: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of human STING in complex with 3',3'-c-di-(2'F,2'dAMP) To Be Published
|
|