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6I6W
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BU of 6i6w by Molmil
Circular permutant of ribosomal protein S6, adding 6aa to C terminal of P68-69
Descriptor: 30S ribosomal protein S6,30S ribosomal protein S6
Authors:Wang, H, Logan, D.T, Oliveberg, M.
Deposit date:2018-11-15
Release date:2019-11-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Exposing the distinctive modular behavior of beta-strands and alpha-helices in folded proteins.
Proc.Natl.Acad.Sci.USA, 117, 2020
6HC9
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STRUCTURE OF GLUA2 LIGAND-BINDING DOMAIN (S1S2J-L504Y-N775S) IN COMPLEX WITH GLUTAMATE AND TDPAM02 AT 2.4 A RESOLUTION.
Descriptor: 6,6'-(ETHANE-1,2-DIYL)BIS(4-CYCLOPROPYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE 1,1-DIOXIDE), CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Laulumaa, S, Hansen, K.V, Frydenvang, K, Kastrup, J.S.
Deposit date:2018-08-14
Release date:2019-04-03
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structures of Potent Dimeric Positive Allosteric Modulators at the Ligand-Binding Domain of the GluA2 Receptor.
Acs Med.Chem.Lett., 10, 2019
6HMW
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BU of 6hmw by Molmil
Cholera toxin classical B-pentamer in complex with fucose
Descriptor: BICINE, CALCIUM ION, Cholera enterotoxin B-subunit, ...
Authors:Krengel, U, Heim, J.B.
Deposit date:2018-09-13
Release date:2019-08-14
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structures of cholera toxin in complex with fucosylated receptors point to importance of secondary binding site.
Sci Rep, 9, 2019
6HCC
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BU of 6hcc by Molmil
STRUCTURE OF GLUA2 LIGAND-BINDING DOMAIN (S1S2J-N775S) IN COMPLEX WITH GLUTAMATE AND TDPAM02 AT 1.6 A RESOLUTION.
Descriptor: 6,6'-(ETHANE-1,2-DIYL)BIS(4-CYCLOPROPYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE 1,1-DIOXIDE), ACETATE ION, CHLORIDE ION, ...
Authors:Laulumaa, S, Hansen, K.V, Frydenvang, K, Kastrup, J.S.
Deposit date:2018-08-14
Release date:2019-04-03
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.617 Å)
Cite:Crystal Structures of Potent Dimeric Positive Allosteric Modulators at the Ligand-Binding Domain of the GluA2 Receptor.
Acs Med.Chem.Lett., 10, 2019
6H1Z
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BU of 6h1z by Molmil
AFGH61B WILD-TYPE
Descriptor: ACETATE ION, COPPER (II) ION, Endoglucanase, ...
Authors:Lo Leggio, L, Poulsen, J.C.N.
Deposit date:2018-07-12
Release date:2018-08-22
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Structure of a lytic polysaccharide monooxygenase from Aspergillus fumigatus and an engineered thermostable variant.
Carbohydr. Res., 469, 2018
6HCH
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BU of 6hch by Molmil
STRUCTURE OF GLUA2 LIGAND-BINDING DOMAIN (S1S2J-L504Y-N775S) IN COMPLEX WITH GLUTAMATE AND TDPAM01 AT 1.6 A RESOLUTION.
Descriptor: 6,6'-(Ethane-1,2-diyl)bis(4-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide), ACETATE ION, CHLORIDE ION, ...
Authors:Laulumaa, S, Hansen, K.V, Frydenvang, K, Kastrup, J.S.
Deposit date:2018-08-15
Release date:2019-04-03
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal Structures of Potent Dimeric Positive Allosteric Modulators at the Ligand-Binding Domain of the GluA2 Receptor.
Acs Med.Chem.Lett., 10, 2019
6I78
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BU of 6i78 by Molmil
Galectin-3C in complex with substituted polyfluoroaryl monothiogalactoside derivative 5
Descriptor: (2~{R},3~{R},4~{S},5~{R},6~{S})-2-(hydroxymethyl)-6-(4-methylphenyl)sulfanyl-4-[4-[2,3,5,6-tetrakis(fluoranyl)-4-(methylamino)phenyl]-1,2,3-triazol-1-yl]oxane-3,5-diol, Galectin-3
Authors:Kumar, R, Peterson, K, Nilsson, U.J, Logan, D.T.
Deposit date:2018-11-15
Release date:2019-01-23
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Substituted polyfluoroaryl interactions with an arginine side chain in galectin-3 are governed by steric-, desolvation and electronic conjugation effects.
Org. Biomol. Chem., 17, 2019
6I6S
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BU of 6i6s by Molmil
Circular permutant of ribosomal protein S6, adding 9aa to C terminal of P68-69, L75A mutant
Descriptor: 30S ribosomal protein S6,30S ribosomal protein S6,30S ribosomal protein S6,30S ribosomal protein S6,30S ribosomal protein S6,30S ribosomal protein S6,30S ribosomal protein S6,30S ribosomal protein S6, POTASSIUM ION, SODIUM ION
Authors:Wang, H, Logan, D.T, Oliveberg, M.
Deposit date:2018-11-15
Release date:2019-11-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:Exposing the distinctive modular behavior of beta-strands and alpha-helices in folded proteins.
Proc.Natl.Acad.Sci.USA, 117, 2020
6I76
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BU of 6i76 by Molmil
Galectin-3C in complex with substituted polyfluoroaryl monothiogalactoside derivative-3
Descriptor: (2~{R},3~{R},4~{S},5~{R},6~{S})-4-[4-[4-azido-2,3,5,6-tetrakis(fluoranyl)phenyl]-1,2,3-triazol-1-yl]-2-(hydroxymethyl)-6-(4-methylphenyl)sulfanyl-oxane-3,5-diol, Galectin-3
Authors:Kumar, R, Peterson, K, Nilsson, U.J, Logan, D.T.
Deposit date:2018-11-15
Release date:2019-01-23
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Substituted polyfluoroaryl interactions with an arginine side chain in galectin-3 are governed by steric-, desolvation and electronic conjugation effects.
Org. Biomol. Chem., 17, 2019
6HMY
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BU of 6hmy by Molmil
Cholera toxin classical B-pentamer in complex with fucosyl-GM1
Descriptor: BICINE, CALCIUM ION, Cholera enterotoxin B-subunit, ...
Authors:Krengel, U, Heim, J.B.
Deposit date:2018-09-13
Release date:2019-08-14
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structures of cholera toxin in complex with fucosylated receptors point to importance of secondary binding site.
Sci Rep, 9, 2019
6HZN
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BU of 6hzn by Molmil
Crystal structure of human dermatan sulfate epimerase 1
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Hasan, M, Unge, J, Westergren-Thorsson, G, Ellervik, U, Mueller, U, Malmstrom, A, Tykesson, E.
Deposit date:2018-10-23
Release date:2020-01-22
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:The structure of human dermatan sulfate epimerase 1 emphasizes the importance of C5-epimerization of glucuronic acid in higher organisms
Chem Sci, 2020
6I8C
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BU of 6i8c by Molmil
Crystal structure of the murine beta-2-microglobulin.
Descriptor: Beta-2-microglobulin, TRIETHYLENE GLYCOL
Authors:Achour, A, Sandalova, T, Ricagno, S, Sun, R.
Deposit date:2018-11-20
Release date:2019-10-02
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Biochemical and biophysical comparison of human and mouse beta-2 microglobulin reveals the molecular determinants of low amyloid propensity.
Febs J., 287, 2020
6I9X
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BU of 6i9x by Molmil
urate oxidase under 35 bar of argon
Descriptor: 8-AZAXANTHINE, ARGON, SODIUM ION, ...
Authors:Prange, T, Colloc'h, N.
Deposit date:2018-11-26
Release date:2019-12-18
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Comparative study of the effects of high hydrostatic pressure per se and high argon pressure on urate oxidase ligand stabilization
Acta Cryst. D, 78, 2022
6IBH
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BU of 6ibh by Molmil
Copper binding protein from Laetisaria arvalis (LaX325)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Auxiliary activity CAZyme, COPPER (II) ION, ...
Authors:Frandsen, K.E.H, Tandrup, T, Labourel, A, Haon, M, Berrin, J.-G, Lo Leggio, L.
Deposit date:2018-11-30
Release date:2019-11-13
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:A fungal family of lytic polysaccharide monooxygenase-like copper proteins.
Nat.Chem.Biol., 16, 2020
6HA5
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BU of 6ha5 by Molmil
AFGH61B L90V/D131S/M134L/A141W VARIANT
Descriptor: ACETATE ION, COPPER (II) ION, Endoglucanase, ...
Authors:Lo Leggio, L, Poulsen, J.C.N.
Deposit date:2018-08-07
Release date:2018-08-22
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Structure of a lytic polysaccharide monooxygenase from Aspergillus fumigatus and an engineered thermostable variant.
Carbohydr. Res., 469, 2018
6HYG
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BU of 6hyg by Molmil
Heteromeric tandem IgG4/IgG1 Fc
Descriptor: IgHG1 and IgHG4 hybrid, ZINC ION
Authors:Casaletto, J.B, Geddie, M.L, Abu-Yousif, A.O, Masson, K, Fulgham, A, Boudot, A, Maiwald, T, Kearns, J.D, Kohli, N, Su, S, Razlog, M, Raue, A, Kalra, A, Hakansson, M, Logan, D.T, Welin, M, Chattopadhyay, S, Harms, B.D, Nielsen, U.B, Schoeberl, B, Lugovskoy, A.A, MacBeath, G.
Deposit date:2018-10-21
Release date:2019-03-13
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:MM-131, a bispecific anti-Met/EpCAM mAb, inhibits HGF-dependent and HGF-independent Met signaling through concurrent binding to EpCAM.
Proc.Natl.Acad.Sci.USA, 116, 2019
6IC6
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BU of 6ic6 by Molmil
Human cathepsin-C in complex with cyclopropyl peptidyl nitrile inhibitor 1
Descriptor: (2~{S})-~{N}-[(1~{R},2~{R})-1-(aminomethyl)-2-[4-[4-(trifluoromethyl)phenyl]phenyl]cyclopropyl]-2-azanyl-butanamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ...
Authors:Hakansson, M, Logan, D.T, Korkmaz, B, Lesner, A, Wysocka, M, Gieldon, A, Gauthier, F, Jenne, D, Lauritzen, C, Pedersen, J.
Deposit date:2018-12-02
Release date:2019-04-24
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.898 Å)
Cite:Structure-based design and in vivo anti-arthritic activity evaluation of a potent dipeptidyl cyclopropyl nitrile inhibitor of cathepsin C.
Biochem. Pharmacol., 164, 2019
6I93
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BU of 6i93 by Molmil
R2-like ligand-binding oxidase G68L mutant with aerobically reconstituted Fe/Fe cofactor
Descriptor: FE (III) ION, OCTANOIC ACID (CAPRYLIC ACID), Ribonucleotide reductase small subunit
Authors:Griese, J.J, Hogbom, M.
Deposit date:2018-11-22
Release date:2019-10-16
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.101 Å)
Cite:Chemical flexibility of heterobimetallic Mn/Fe cofactors: R2lox and R2c proteins.
J.Biol.Chem., 294, 2019
6IAO
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BU of 6iao by Molmil
Structure of Cytochrome P450 BM3 M11 mutant in complex with DTT at resolution 2.16A
Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Bifunctional cytochrome P450/NADPH--P450 reductase, CHLORIDE ION, ...
Authors:Mirza, O, Rafiq, M, Frydenvang, K.
Deposit date:2018-11-27
Release date:2019-06-05
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Structural analysis of Cytochrome P450 BM3 mutant M11 in complex with dithiothreitol.
Plos One, 14, 2019
6I74
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BU of 6i74 by Molmil
Galectin-3C in complex with substituted polyfluoroaryl monothiogalactoside derivative 1
Descriptor: (2~{R},3~{R},4~{S},5~{R},6~{S})-2-(hydroxymethyl)-6-(4-methylphenyl)sulfanyl-4-[4-[2,3,4,5,6-pentakis(fluoranyl)phenyl]-1,2,3-triazol-1-yl]oxane-3,5-diol, Galectin-3
Authors:Kumar, R, Peterson, K, Nilsson, U.J, Logan, D.T.
Deposit date:2018-11-15
Release date:2019-01-23
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (0.959 Å)
Cite:Substituted polyfluoroaryl interactions with an arginine side chain in galectin-3 are governed by steric-, desolvation and electronic conjugation effects.
Org. Biomol. Chem., 17, 2019
6RZI
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BU of 6rzi by Molmil
Galectin-3C in complex with trifluoroaryltriazole monothiogalactoside derivative:1(Hydrogen)
Descriptor: (2~{R},3~{R},4~{S},5~{R},6~{R})-2-(hydroxymethyl)-6-phenylsulfanyl-4-[4-[3,4,5-tris(fluoranyl)phenyl]-1,2,3-triazol-1-yl]oxane-3,5-diol, Galectin-3, THIOCYANATE ION
Authors:Kumar, R, Verteramo, M.L, Nilsson, U.J, Logan, D.T.
Deposit date:2019-06-13
Release date:2020-07-08
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.095 Å)
Cite:Thermodynamic studies of halogen-bond interactions in galectin-3
to be published
6RZM
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BU of 6rzm by Molmil
Galectin-3C in complex with trifluoroaryltriazole monothiogalactoside derivative:5(Iodine)
Descriptor: (2~{R},3~{R},4~{S},5~{R},6~{R})-2-(hydroxymethyl)-6-(3-iodanylphenyl)sulfanyl-4-[4-[3,4,5-tris(fluoranyl)phenyl]-1,2,3-triazol-1-yl]oxane-3,5-diol, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Kumar, R, Verteramo, M.L, Nilsson, U.J, Logan, D.T.
Deposit date:2019-06-13
Release date:2020-07-08
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.345 Å)
Cite:Thermodynamic studies of halogen-bond interactions in galectin-3
to be published
6RS7
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BU of 6rs7 by Molmil
X-ray crystal structure of LsAA9B (deglycosylated form)
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, AA9, ...
Authors:Frandsen, K.E.H, Tovborg, M, Poulsen, J.C.N, Johansen, K.S, Lo Leggio, L.
Deposit date:2019-05-21
Release date:2019-09-11
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Insights into an unusual Auxiliary Activity 9 family member lacking the histidine brace motif of lytic polysaccharide monooxygenases.
J.Biol.Chem., 294, 2019
6RZJ
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BU of 6rzj by Molmil
Galectin-3C in complex with trifluoroaryltriazole monothiogalactoside derivative:2(Fluorine)
Descriptor: (2~{R},3~{R},4~{S},5~{R},6~{R})-2-(3-fluorophenyl)sulfanyl-6-(hydroxymethyl)-4-[4-[3,4,5-tris(fluoranyl)phenyl]-1,2,3-triazol-1-yl]oxane-3,5-diol, Galectin-3, THIOCYANATE ION
Authors:Kumar, R, Verteramo, M.L, Nilsson, U.J, Logan, D.T.
Deposit date:2019-06-13
Release date:2020-07-08
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.097 Å)
Cite:Thermodynamic studies of halogen-bond interactions in galectin-3
to be published
6RZK
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BU of 6rzk by Molmil
Galectin-3C in complex with trifluoroaryltriazole monothiogalactoside derivative:3(Chlorine)
Descriptor: (2~{R},3~{R},4~{S},5~{R},6~{R})-2-(3-chlorophenyl)sulfanyl-6-(hydroxymethyl)-4-[4-[3,4,5-tris(fluoranyl)phenyl]-1,2,3-triazol-1-yl]oxane-3,5-diol, CHLORIDE ION, Galectin-3
Authors:Kumar, R, Verteramo, M.L, Nilsson, U.J, Logan, D.T.
Deposit date:2019-06-13
Release date:2020-07-08
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.046 Å)
Cite:Thermodynamic studies of halogen-bond interactions in galectin-3
to be published

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