6HCH
STRUCTURE OF GLUA2 LIGAND-BINDING DOMAIN (S1S2J-L504Y-N775S) IN COMPLEX WITH GLUTAMATE AND TDPAM01 AT 1.6 A RESOLUTION.
Summary for 6HCH
| Entry DOI | 10.2210/pdb6hch/pdb |
| Descriptor | Glutamate receptor 2, GLUTAMIC ACID, ZINC ION, ... (9 entities in total) |
| Functional Keywords | ampa receptor, glua2, ligand-binding domain, glua2-s1s2j-l504y-n775s, membrane protein, signaling protein, positive allosteric modulator |
| Biological source | Rattus norvegicus (Rat) More |
| Total number of polymer chains | 3 |
| Total formula weight | 91554.99 |
| Authors | Laulumaa, S.,Hansen, K.V.,Frydenvang, K.,Kastrup, J.S. (deposition date: 2018-08-15, release date: 2019-04-03, Last modification date: 2024-01-17) |
| Primary citation | Laulumaa, S.,Hansen, K.V.,Masternak, M.,Drapier, T.,Francotte, P.,Pirotte, B.,Frydenvang, K.,Kastrup, J.S. Crystal Structures of Potent Dimeric Positive Allosteric Modulators at the Ligand-Binding Domain of the GluA2 Receptor. Acs Med.Chem.Lett., 10:243-247, 2019 Cited by PubMed: 30891120DOI: 10.1021/acsmedchemlett.8b00369 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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