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7DTC
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voltage-gated sodium channel Nav1.5-E1784K
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Sodium channel protein type 5 subunit alpha
Authors:Yan, N, Pan, X, Li, Z.
Deposit date:2021-01-04
Release date:2021-03-24
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structure of human Na v 1.5 reveals the fast inactivation-related segments as a mutational hotspot for the long QT syndrome.
Proc.Natl.Acad.Sci.USA, 118, 2021
7XUF
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Cryo-EM structure of the AKT1-AtKC1 complex from Arabidopsis thaliana
Descriptor: POTASSIUM ION, Potassium channel AKT1, Potassium channel KAT3
Authors:Yang, G.H, Lu, Y.M, Jia, Y.T, Yang, F, Zhang, Y.M, Xu, X, Li, X.M, Lei, J.L.
Deposit date:2022-05-18
Release date:2022-11-09
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural basis for the activity regulation of a potassium channel AKT1 from Arabidopsis.
Nat Commun, 13, 2022
7FHK
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BU of 7fhk by Molmil
Structure of AtTPC1 with 1 mM Ca2+
Descriptor: AtTPC1-Cter, CALCIUM ION, Two pore calcium channel protein 1,GFP
Authors:Ye, F, Xu, L, Li, X, Jiang, Y, Guo, J.
Deposit date:2021-07-29
Release date:2021-12-01
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Voltage-gating and cytosolic Ca 2+ activation mechanisms of Arabidopsis two-pore channel AtTPC1.
Proc.Natl.Acad.Sci.USA, 118, 2021
7FHN
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Structure of AtTPC1 D240A/D454A/E528A mutant with 1 mM Ca2+
Descriptor: CALCIUM ION, Two pore calcium channel protein 1,GFP
Authors:Ye, F, Xu, L, Li, X, Jiang, Y, Guo, J.
Deposit date:2021-07-29
Release date:2021-12-01
Last modified:2022-03-16
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Voltage-gating and cytosolic Ca 2+ activation mechanisms of Arabidopsis two-pore channel AtTPC1.
Proc.Natl.Acad.Sci.USA, 118, 2021
6DRJ
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BU of 6drj by Molmil
Structure of TRPM2 ion channel receptor by single particle electron cryo-microscopy, ADPR/Ca2+ bound state
Descriptor: ADENOSINE-5-DIPHOSPHORIBOSE, CALCIUM ION, Transient receptor potential cation channel, ...
Authors:Du, J, Lu, W, Huang, Y, Winkler, P, Sun, W.
Deposit date:2018-06-12
Release date:2018-09-19
Last modified:2018-10-10
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Architecture of the TRPM2 channel and its activation mechanism by ADP-ribose and calcium.
Nature, 562, 2018
7W77
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cryo-EM structure of human NaV1.3/beta1/beta2-bulleyaconitineA
Descriptor: (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Jiang, D, Li, X.
Deposit date:2021-12-03
Release date:2022-04-06
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural basis for modulation of human Na V 1.3 by clinical drug and selective antagonist.
Nat Commun, 13, 2022
5WIE
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Crystal structure of a Kv1.2-2.1 chimera K+ channel V406W mutant in an inactivated state
Descriptor: (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, POTASSIUM ION, ...
Authors:Pau, V, Zhou, Y, Ramu, Y, Xu, Y, Lu, Z.
Deposit date:2017-07-19
Release date:2017-08-30
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Crystal structure of an inactivated mutant mammalian voltage-gated K(+) channel.
Nat. Struct. Mol. Biol., 24, 2017
7L2R
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Cryo-EM structure of DkTx-bound minimal TRPV1 at the pre-open state
Descriptor: (2S)-1-(butanoyloxy)-3-{[(R)-hydroxy{[(1r,2R,3S,4S,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propan-2-yl tridecanoate, (9R,12R)-15-amino-12-hydroxy-6,12-dioxo-7,11,13-trioxa-12lambda~5~-phosphapentadecan-9-yl undecanoate, SODIUM ION, ...
Authors:Zhang, K, Julius, D, Cheng, Y.
Deposit date:2020-12-17
Release date:2021-09-22
Last modified:2021-10-13
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural snapshots of TRPV1 reveal mechanism of polymodal functionality.
Cell, 184, 2021
5E1J
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Structure of voltage-gated two-pore channel TPC1 from Arabidopsis thaliana
Descriptor: BARIUM ION, CALCIUM ION, Two pore calcium channel protein 1
Authors:Guo, J, Zeng, W, Chen, Q, Lee, C, Chen, L, Yang, Y, Jiang, Y.
Deposit date:2015-09-29
Release date:2015-12-16
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (3.308 Å)
Cite:Structure of the voltage-gated two-pore channel TPC1 from Arabidopsis thaliana.
Nature, 531, 2016
4P30
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BU of 4p30 by Molmil
Structure of NavMS mutant in presence of PI1 compound
Descriptor: DODECAETHYLENE GLYCOL, HEGA-10, Ion transport protein, ...
Authors:Bagneris, C, Naylor, C.E, Wallace, B.A.
Deposit date:2014-03-05
Release date:2014-06-04
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.31 Å)
Cite:Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism.
Proc.Natl.Acad.Sci.USA, 111, 2014
7RHI
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Cryo-EM structure of human rod CNGA1/B1 channel in cGMP-bound openII state
Descriptor: CYCLIC GUANOSINE MONOPHOSPHATE, Cyclic nucleotide-gated cation channel beta-1, cGMP-gated cation channel alpha-1
Authors:Xue, J, Han, Y, Jiang, Y.
Deposit date:2021-07-17
Release date:2021-11-03
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.31 Å)
Cite:Structural mechanisms of assembly, permeation, gating, and pharmacology of native human rod CNG channel.
Neuron, 110, 2022
7RHH
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Cryo-EM structure of human rod CNGA1/B1 channel in cGMP-bound openI state
Descriptor: CYCLIC GUANOSINE MONOPHOSPHATE, Cyclic nucleotide-gated cation channel beta-1, cGMP-gated cation channel alpha-1
Authors:Xue, J, Han, Y, Jiang, Y.
Deposit date:2021-07-17
Release date:2021-11-03
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.31 Å)
Cite:Structural mechanisms of assembly, permeation, gating, and pharmacology of native human rod CNG channel.
Neuron, 110, 2022
5WO6
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BU of 5wo6 by Molmil
Crystal Structure of Transient Receptor Potential (TRP) channel TRPV6cryst
Descriptor: 6-(5-METHYL-2-OXO-IMIDAZOLIDIN-4-YL)-HEXANOIC ACID, CALCIUM ION, Transient receptor potential cation channel subfamily V member 6
Authors:Singh, A.K, Saotome, K, Sobolevsky, A.I.
Deposit date:2017-08-01
Release date:2017-09-13
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.31 Å)
Cite:Swapping of transmembrane domains in the epithelial calcium channel TRPV6.
Sci Rep, 7, 2017
7SIT
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BU of 7sit by Molmil
Crystal structure of Voltage gated potassium ion channel, Kv 1.2 chimera-3m
Descriptor: NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, OXYGEN ATOM, POTASSIUM ION, ...
Authors:Reddi, R, Matulef, K, Riederer, E.A, Whorton, M.R, Valiyaveetil, F.I.
Deposit date:2021-10-14
Release date:2022-05-04
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.32 Å)
Cite:Structural basis for C-type inactivation in a Shaker family voltage-gated K + channel.
Sci Adv, 8, 2022
8SDA
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BU of 8sda by Molmil
CryoEM structure of rat Kv2.1(1-598) L403A mutant in nanodiscs
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, POTASSIUM ION, Potassium voltage-gated channel subfamily B member 1
Authors:Tan, X, Swartz, K.J.
Deposit date:2023-04-06
Release date:2023-09-27
Last modified:2023-10-25
Method:ELECTRON MICROSCOPY (3.32 Å)
Cite:Inactivation of the Kv2.1 channel through electromechanical coupling.
Nature, 622, 2023
8E4L
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BU of 8e4l by Molmil
The open state mouse TRPM8 structure in complex with the cooling agonist C3, AITC, and PI(4,5)P2
Descriptor: 3-isothiocyanatoprop-1-ene, CALCIUM ION, Transient receptor potential cation channel subfamily M member 8, ...
Authors:Yin, Y, Zhang, F, Feng, S, Butay, K.J, Borgnia, M.J, Im, W, Lee, S.-Y.
Deposit date:2022-08-18
Release date:2022-10-26
Method:ELECTRON MICROSCOPY (3.32 Å)
Cite:Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2.
Science, 378, 2022
7RQZ
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BU of 7rqz by Molmil
Cryo-EM structure of the full-length TRPV1 with RTx at 48 degrees Celsius, in an open state, class alpha
Descriptor: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Transient receptor potential cation channel subfamily V member 1, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate, ...
Authors:Kwon, D.H, Suo, Y, Lee, S.-Y.
Deposit date:2021-08-08
Release date:2022-06-01
Method:ELECTRON MICROSCOPY (3.32 Å)
Cite:Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis.
Nat Commun, 13, 2022
8SLY
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BU of 8sly by Molmil
Rat TRPV2 bound with 2 CBD ligands in nanodiscs
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, SODIUM ION, Transient receptor potential cation channel subfamily V member 2, ...
Authors:Tan, X, Swartz, K.J.
Deposit date:2023-04-24
Release date:2023-05-31
Last modified:2023-07-05
Method:ELECTRON MICROSCOPY (3.32 Å)
Cite:Cannabidiol sensitizes TRPV2 channels to activation by 2-APB.
Elife, 12, 2023
6DQN
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BU of 6dqn by Molmil
Class 1 IP3-bound human type 3 1,4,5-inositol trisphosphate receptor
Descriptor: D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, Inositol 1,4,5-trisphosphate receptor type 3, ZINC ION
Authors:Hite, R.K, Paknejad, N.
Deposit date:2018-06-11
Release date:2018-08-01
Last modified:2019-11-20
Method:ELECTRON MICROSCOPY (3.33 Å)
Cite:Structural basis for the regulation of inositol trisphosphate receptors by Ca2+and IP3.
Nat. Struct. Mol. Biol., 25, 2018
8EVA
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BU of 8eva by Molmil
Cryo-EM structure of cGMP bound truncated human CNGA3/CNGB3 channel in lipid nanodisc, transition state 2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CYCLIC GUANOSINE MONOPHOSPHATE, Cyclic nucleotide-gated cation channel alpha-3, ...
Authors:Hu, Z, Yang, J.
Deposit date:2022-10-20
Release date:2023-08-09
Method:ELECTRON MICROSCOPY (3.33 Å)
Cite:Conformational trajectory of allosteric gating of the human cone photoreceptor cyclic nucleotide-gated channel.
Nat Commun, 14, 2023
8EV9
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BU of 8ev9 by Molmil
Cryo-EM structure of cGMP bound truncated human CNGA3/CNGB3 channel in lipid nanodisc, transition state 1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CYCLIC GUANOSINE MONOPHOSPHATE, Cyclic nucleotide-gated cation channel alpha-3, ...
Authors:Hu, Z, Yang, J.
Deposit date:2022-10-20
Release date:2023-08-09
Method:ELECTRON MICROSCOPY (3.33 Å)
Cite:Conformational trajectory of allosteric gating of the human cone photoreceptor cyclic nucleotide-gated channel.
Nat Commun, 14, 2023
8EVC
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BU of 8evc by Molmil
Cryo-EM structure of cGMP bound truncated human CNGA3/CNGB3 channel in lipid nanodisc, open state
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CYCLIC GUANOSINE MONOPHOSPHATE, Cyclic nucleotide-gated cation channel alpha-3, ...
Authors:Hu, Z, Yang, J.
Deposit date:2022-10-20
Release date:2023-08-09
Method:ELECTRON MICROSCOPY (3.33 Å)
Cite:Conformational trajectory of allosteric gating of the human cone photoreceptor cyclic nucleotide-gated channel.
Nat Commun, 14, 2023
5IWO
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BU of 5iwo by Molmil
Bacterial sodium channel pore domain, low bromide
Descriptor: BROMIDE ION, Ion transport protein
Authors:Shaya, D, Findeisen, F, Rohaim, A, Minor, D.L.
Deposit date:2016-03-22
Release date:2016-03-30
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.33 Å)
Cite:Unfolding of a Temperature-Sensitive Domain Controls Voltage-Gated Channel Activation.
Cell, 164, 2016
7MZ7
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BU of 7mz7 by Molmil
Cryo-EM structure of minimal TRPV1 with 4 partially bound RTX
Descriptor: SODIUM ION, Transient receptor potential cation channel subfamily V member 1, resiniferatoxin
Authors:Zhang, K, Julius, D, Cheng, Y.
Deposit date:2021-05-24
Release date:2021-09-22
Last modified:2021-10-13
Method:ELECTRON MICROSCOPY (3.35 Å)
Cite:Structural snapshots of TRPV1 reveal mechanism of polymodal functionality.
Cell, 184, 2021
8T1D
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BU of 8t1d by Molmil
Open-state cryo-EM structure of full-length human TRPV4 in complex with agonist 4a-PDD
Descriptor: (1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-9a-(decanoyloxy)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl decanoate, Transient receptor potential cation channel subfamily V member 4/Enhanced green fluorescent protein chimera
Authors:Talyzina, I.A, Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I.
Deposit date:2023-06-02
Release date:2023-07-05
Method:ELECTRON MICROSCOPY (3.35 Å)
Cite:Structure of human TRPV4 in complex with GTPase RhoA.
Nat Commun, 14, 2023

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