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8C43	Ternary structure of 14-3-3sigma, strep-tagged PKA-responsive ERa phosphopeptide, and Fusicoccin-A. Descriptor: 14-3-3 protein sigma, De-acetylated Fusicoccin, Estrogen Receptor alpha phosphopeptide, ... Authors: Somsen, B.A, Ottmann, C. Deposit date: 2022-12-30 Release date: 2023-12-27 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Molecular basis and dual ligand regulation of tetrameric estrogen receptor alpha /14-3-3 zeta protein complex. J.Biol.Chem., 299, 2023
6FEL	Structure of 14-3-3 gamma in complex with CaMKK2 14-3-3 binding motif Ser511 Descriptor: 14-3-3 protein gamma, Calcium/calmodulin-dependent protein kinase kinase 2 Authors: Lentini Santo, D, Obsilova, V, Obsil, T. Deposit date: 2018-01-02 Release date: 2018-01-10 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.84 Å) Cite: 14-3-3 protein directly interacts with the kinase domain of calcium/calmodulin-dependent protein kinase kinase (CaMKK2). Biochim. Biophys. Acta, 1862, 2018
3AXY	Structure of Florigen Activation Complex Consisting of Rice Florigen Hd3a, 14-3-3 Protein GF14 and Rice FD Homolog OsFD1 Descriptor: 14-3-3-like protein GF14-C, Protein HEADING DATE 3A, Rice FD homolog OsFD1 Authors: Ohki, I, Furuita, K, Hayashi, K, Taoka, K, Tsuji, H, Nakagawa, A, Shimamoto, K, Kojima, C. Deposit date: 2011-04-19 Release date: 2011-08-03 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.4 Å) Cite: 14-3-3 proteins act as intracellular receptors for rice Hd3a florigen Nature, 476, 2011
7NMZ	Structure of 14-3-3 eta in complex with Nedd4-2(335-455) containing two 14-3-3 binding motifs Ser342 and Ser448 Descriptor: 14-3-3 protein eta, E3 ubiquitin-protein ligase NEDD4-like Authors: Pohl, P, Obsil, T, Obsilova, V. Deposit date: 2021-02-23 Release date: 2021-07-21 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.303 Å) Cite: 14-3-3-protein regulates Nedd4-2 by modulating interactions between HECT and WW domains. Commun Biol, 4, 2021
6CR2	Crystal structure of sterol 14-alpha demethylase (CYP51B) from Aspergillus fumigatus in complex with the VNI derivative N-(1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethyl)-4-(5-(2-fluoro-4-(2,2,2-trifluoroethoxy)phenyl)-1,3,4-oxadiazol-2-yl)benzamide Descriptor: 14-alpha sterol demethylase Cyp51B, N-[(1R)-1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethyl]-4-{5-[2-fluoro-4-(2,2,2-trifluoroethoxy)phenyl]-1,3,4-oxadiazol-2-yl}benzamide, PROTOPORPHYRIN IX CONTAINING FE Authors: Friggeri, L, Hargrove, T.Y, Wawrzak, Z, Lepesheva, G.I. Deposit date: 2018-03-16 Release date: 2018-06-27 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.38 Å) Cite: Sterol 14 alpha-Demethylase Structure-Based Design of VNI (( R)- N-(1-(2,4-Dichlorophenyl)-2-(1 H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide)) Derivatives To Target Fungal Infections: Synthesis, Biological Evaluation, and Crystallographic Analysis. J. Med. Chem., 61, 2018
6SAD	Structure of 14-3-3 gamma in complex with double phosphorylated caspase-2 peptide on Ser139 and Ser164 Descriptor: 14-3-3 protein gamma, Caspase-2 Authors: Kalabova, D, Obsil, T, Obsilova, V. Deposit date: 2019-07-16 Release date: 2020-01-22 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.753 Å) Cite: 14-3-3 protein binding blocks the dimerization interface of caspase-2. Febs J., 287, 2020
8DS6	Structure of the PEAK3 pseudokinase homodimer Descriptor: Protein PEAK3 Authors: Torosyan, H, Paul, M, Jura, N, Verba, K.A. Deposit date: 2022-07-21 Release date: 2023-06-28 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (4.9 Å) Cite: Structural insights into regulation of the PEAK3 pseudokinase scaffold by 14-3-3. Nat Commun, 14, 2023
7ZIT	14-3-3 in complex with SARS-COV2 N phospho-peptide Descriptor: 14-3-3 protein zeta/delta, ACETATE ION, BENZOIC ACID, ... Authors: Eisenreichova, A, Boura, E. Deposit date: 2022-04-08 Release date: 2022-10-26 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.79 Å) Cite: Structural basis for SARS-CoV-2 nucleocapsid (N) protein recognition by 14-3-3 proteins. J.Struct.Biol., 214, 2022
6J14	Complex structure of GY-14 and PD-1 Descriptor: GY-14 heavy chain V fragment, GY-14 light chain V fragment, Programmed cell death protein 1 Authors: Chen, D, Tan, S, Whang, H, Zhang, H, Chai, Y, Qi, J, Yan, J, Gao, G.F. Deposit date: 2018-12-27 Release date: 2019-11-06 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.4 Å) Cite: The FG Loop of PD-1 Serves as a "Hotspot" for Therapeutic Monoclonal Antibodies in Tumor Immune Checkpoint Therapy. Iscience, 14, 2019
8DGO	Growth Factor Receptor-Bound Protein 2 (Grb2) bound to phosphorylated PEAK3 (pY24) peptide Descriptor: Growth factor receptor bound protein 2, Phosphorylated PEAK3 (pY24) peptide Authors: Roy, M.J, Hardy, J.M, Lucet, I.S. Deposit date: 2022-06-24 Release date: 2023-06-07 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural mapping of PEAK pseudokinase interactions identifies 14-3-3 as a molecular switch for PEAK3 signaling. Nat Commun, 14, 2023
8R2I	Cryo-EM Structure of native Photosystem II assembly intermediate from Chlamydomonas reinhardtii Descriptor: 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, 2,3-DIMETHYL-5-(3,7,11,15,19,23,27,31,35-NONAMETHYL-2,6,10,14,18,22,26,30,34-HEXATRIACONTANONAENYL-2,5-CYCLOHEXADIENE-1,4-DIONE-2,3-DIMETHYL-5-SOLANESYL-1,4-BENZOQUINONE, ... Authors: Fadeeva, M, Klaiman, D, Kandiah, E, Nelson, N. Deposit date: 2023-11-06 Release date: 2024-01-31 Last modified: 2024-02-21 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Structure of native photosystem II assembly intermediate from Chlamydomonas reinhardtii . Front Plant Sci, 14, 2023
4FJ3	14-3-3 isoform zeta in complex with a diphoyphorylated C-RAF peptide Descriptor: 14-3-3 protein zeta/delta, RAF proto-oncogene serine/threonine-protein kinase Authors: Ottmann, C, Molzan, M. Deposit date: 2012-06-11 Release date: 2012-09-05 Last modified: 2013-07-10 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Synergistic binding of the phosphorylated S233- and S259-binding sites of C-RAF to one 14-3-3zeta dimer J.Mol.Biol., 423, 2012
6KZH	14-3-3 protein in Complex with CIC S173 phosphorylated peptide Descriptor: 14-3-3 protein theta, CIC pS173 peptide Authors: Wen, Y, Shao, Y. Deposit date: 2019-09-24 Release date: 2020-09-30 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.645 Å) Cite: 14-3-3 protein in Complex with CIC S173 phosphorylated peptide To Be Published
6KZG	14-3-3 protein in Complex with CIC S301 phosphorylated peptide Descriptor: 14-3-3 protein theta, ARG-SER-MET-SER-GLU-THR-GLY-THR Authors: Wen, Y, Shao, Y. Deposit date: 2019-09-24 Release date: 2020-09-30 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2 Å) Cite: 14-3-3 protein in Complex with CIC S301 phosphorylated peptide To Be Published
6EF5	14-3-3 with peptide Descriptor: 14-3-3 protein zeta/delta, ARG-SER-LEU-SEP-ALA-PRO-GLY, LYS-LEU-SEP-LEU-GLN Authors: Dhagat, U, Langendorf, C.G, Parker, M.W.P, Oakhill, J.S, Scott, J.W. Deposit date: 2018-08-16 Release date: 2019-10-30 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.44 Å) Cite: 14-3-3 with peptide To Be Published
1HRI	STRUCTURE DETERMINATION OF ANTIVIRAL COMPOUND SCH 38057 COMPLEXED WITH HUMAN RHINOVIRUS 14 Descriptor: 1-[6-(2-CHLORO-4-METHYXYPHENOXY)-HEXYL]-IMIDAZOLE, HUMAN RHINOVIRUS 14 COAT PROTEIN (SUBUNIT VP1), HUMAN RHINOVIRUS 14 COAT PROTEIN (SUBUNIT VP2), ... Authors: Zhang, A, Nanni, R.G, Oren, D.A, Arnold, E. Deposit date: 1992-10-01 Release date: 1993-10-31 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (3 Å) Cite: Structure determination of antiviral compound SCH 38057 complexed with human rhinovirus 14. J.Mol.Biol., 230, 1993
8C2D	14-3-3 in complex with Pyrin pS208 Descriptor: 14-3-3 protein sigma, MAGNESIUM ION, Pyrin pS208 peptide Authors: Lau, R, Ottmann, C, Hann, M. Deposit date: 2022-12-22 Release date: 2023-07-26 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Crystal structure and ligandability of the 14-3-3/pyrin interface. Biochem.Biophys.Res.Commun., 651, 2023
2RMU	THREE-DIMENSIONAL STRUCTURES OF DRUG-RESISTANT MUTANTS OF HUMAN RHINOVIRUS 14 Descriptor: HUMAN RHINOVIRUS 14 COAT PROTEIN (SUBUNIT VP1), HUMAN RHINOVIRUS 14 COAT PROTEIN (SUBUNIT VP2), HUMAN RHINOVIRUS 14 COAT PROTEIN (SUBUNIT VP3), ... Authors: Badger, J, Krishnaswamy, S, Kremer, M.J, Oliveira, M.A, Rossmann, M.G, Heinz, B.A, Rueckert, R.R, Dutko, F.J, Mckinlay, M.A. Deposit date: 1988-10-03 Release date: 1990-01-15 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (3 Å) Cite: Three-dimensional structures of drug-resistant mutants of human rhinovirus 14. J.Mol.Biol., 207, 1989
4HKC	14-3-3-zeta in complex with S1011 phosphorylated integrin alpha-4 peptide Descriptor: 14-3-3 protein zeta/delta, GLYCEROL, alpha-4 integrin derived phosphorylated peptide Authors: Bonet, R, Campbell, I.D. Deposit date: 2012-10-15 Release date: 2013-06-26 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Characterization of 14-3-3-zeta Interactions with integrin tails J.Mol.Biol., 425, 2013
4IEA	14-3-3 isoform sigma in complex with a phosphorylated C-RAF peptide Descriptor: 14-3-3 protein sigma, RAF proto-oncogene serine/threonine-protein kinase Authors: Molzan, M, Ottmann, C. Deposit date: 2012-12-13 Release date: 2013-09-25 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Stabilization of Physical RAF/14-3-3 Interaction by Cotylenin A as Treatment Strategy for RAS Mutant Cancers. Acs Chem.Biol., 8, 2013
2V7D	14-3-3 protein zeta in complex with Thr758 phosphorylated integrin beta2 peptide Descriptor: 14-3-3 PROTEIN ZETA/DELTA, INTEGRIN BETA CHAIN, BETA 2 VARIANT Authors: Takala, H, Ylanne, J. Deposit date: 2007-07-30 Release date: 2008-06-24 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Beta2 Integrin Phosphorylation on Thr758 Acts as a Molecular Switch to Regulate 14-3-3 and Filamin Binding. Blood, 112, 2008
1RMU	THREE-DIMENSIONAL STRUCTURES OF DRUG-RESISTANT MUTANTS OF HUMAN RHINOVIRUS 14 Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, HUMAN RHINOVIRUS 14 COAT PROTEIN (SUBUNIT VP1), HUMAN RHINOVIRUS 14 COAT PROTEIN (SUBUNIT VP2), ... Authors: Badger, J, Krishnaswamy, S, Kremer, M.J, Oliveira, M.A, Rossmann, M.G, Heinz, B.A, Rueckert, R.R, Dutko, F.J, Mckinlay, M.A. Deposit date: 1988-10-03 Release date: 1990-01-15 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (3 Å) Cite: Three-dimensional structures of drug-resistant mutants of human rhinovirus 14. J.Mol.Biol., 207, 1989
1R09	HUMAN RHINOVIRUS 14 COMPLEXED WITH ANTIVIRAL COMPOUND R 61837 Descriptor: 3-METHOXY-6-[4-(3-METHYLPHENYL)-1-PIPERAZINYL]PYRIDAZINE, DIMETHYL SULFOXIDE, HUMAN RHINOVIRUS 14 COAT PROTEIN (SUBUNIT VP1), ... Authors: Chapman, M.S, Minor, I, Rossmann, M.G, Diana, G.D, Andries, K. Deposit date: 1990-05-04 Release date: 1991-10-15 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Human rhinovirus 14 complexed with antiviral compound R 61837. J.Mol.Biol., 217, 1991
1RUC	RHINOVIRUS 14 MUTANT N1105S COMPLEXED WITH ANTIVIRAL COMPOUND WIN 52035 Descriptor: 5-(5-(4-(4,5-DIHYDRO-2-OXAZOLY)PHENOXY)PENTYL)-3-METHYL ISOXAZOLE, RHINOVIRUS 14 Authors: Hadfield, A, Oliveira, M.A, Kim, K.H, Minor, I, Kremer, M.J, Heinz, B.A, Shepard, D, Pevear, D.C, Rueckert, R.R, Rossmann, M.G. Deposit date: 1995-06-09 Release date: 1995-11-14 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Structural studies on human rhinovirus 14 drug-resistant compensation mutants. J.Mol.Biol., 253, 1995
1RUI	RHINOVIRUS 14 MUTANT S1223G COMPLEXED WITH ANTIVIRAL COMPOUND WIN 52084 Descriptor: 5-(7-(5-HYDRO-4-METHYL-2-OXAZOLYL)PHENOXY)HEPTYL)-3-METHYL ISOXAZOLE, RHINOVIRUS 14 Authors: Hadfield, A, Oliveira, M.A, Kim, K.H, Minor, I, Kremer, M.J, Heinz, B.A, Shepard, D, Pevear, D.C, Rueckert, R.R, Rossmann, M.G. Deposit date: 1995-06-09 Release date: 1995-11-14 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (3 Å) Cite: Structural studies on human rhinovirus 14 drug-resistant compensation mutants. J.Mol.Biol., 253, 1995

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