PDB: 309 resultsInfo pagesStatus searchChemie searchBIRD

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7L2M	Cryo-EM structure of DkTx/RTX-bound full-length TRPV1 Descriptor: SODIUM ION, Tau-theraphotoxin-Hs1a, Transient receptor potential cation channel subfamily V member 1, ... Authors: Zhang, K, Julius, D, Cheng, Y. Deposit date: 2020-12-17 Release date: 2021-09-22 Last modified: 2021-10-13 Method: ELECTRON MICROSCOPY (3.84 Å) Cite: Structural snapshots of TRPV1 reveal mechanism of polymodal functionality. Cell, 184, 2021
7L2K	Cryo-EM structure of full-length TRPV1 at pH6b state Descriptor: Transient receptor potential cation channel subfamily V member 1 Authors: Zhang, K, Julius, D, Cheng, Y. Deposit date: 2020-12-17 Release date: 2021-09-22 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (3.89 Å) Cite: Structural snapshots of TRPV1 reveal mechanism of polymodal functionality. Cell, 184, 2021
7L2I	Cryo-EM structure of full-length TRPV1 at pH6a state Descriptor: (2S)-1-(butanoyloxy)-3-{[(R)-hydroxy{[(1S,2R,3R,4R,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propan-2-yl tridecanoate, Transient receptor potential cation channel subfamily V member 1 Authors: Zhang, K, Julius, D, Cheng, Y. Deposit date: 2020-12-17 Release date: 2021-09-22 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Structural snapshots of TRPV1 reveal mechanism of polymodal functionality. Cell, 184, 2021
7L2U	cryo-EM structure of DkTx-bound minimal TRPV1 in open state Descriptor: (11R,14S)-17-amino-14-hydroxy-8,14-dioxo-9,13,15-trioxa-14lambda~5~-phosphaheptadecan-11-yl decanoate, (2S)-1-(butanoyloxy)-3-{[(R)-hydroxy{[(1r,2R,3S,4S,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propan-2-yl tridecanoate, SODIUM ION, ... Authors: Zhang, K, Julius, D, Cheng, Y. Deposit date: 2020-12-17 Release date: 2021-09-22 Last modified: 2021-10-13 Method: ELECTRON MICROSCOPY (3.47 Å) Cite: Structural snapshots of TRPV1 reveal mechanism of polymodal functionality. Cell, 184, 2021
7L2H	Cryo-EM structure of unliganded full-length TRPV1 at neutral pH Descriptor: (10R,13S)-16-amino-13-hydroxy-7,13-dioxo-8,12,14-trioxa-13lambda~5~-phosphahexadecan-10-yl tridecanoate, (2S)-1-(butanoyloxy)-3-{[(R)-hydroxy{[(1r,2R,3S,4S,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propan-2-yl tridecanoate, SODIUM ION, ... Authors: Zhang, K, Julius, D, Cheng, Y. Deposit date: 2020-12-17 Release date: 2021-09-22 Last modified: 2021-10-13 Method: ELECTRON MICROSCOPY (2.63 Å) Cite: Structural snapshots of TRPV1 reveal mechanism of polymodal functionality. Cell, 184, 2021
7L2V	cryo-EM structure of RTX-bound minimal TRPV1 with NMDG at state b Descriptor: 6-deoxy-6-(methylamino)-D-galactitol, SODIUM ION, Transient receptor potential cation channel subfamily V member 1, ... Authors: Zhang, K, Julius, D, Cheng, Y. Deposit date: 2020-12-17 Release date: 2021-09-22 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (3.64 Å) Cite: Structural snapshots of TRPV1 reveal mechanism of polymodal functionality. Cell, 184, 2021
7LQY	Structure of squirrel TRPV1 in apo state Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoinositol, CHLORIDE ION, ... Authors: Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. Deposit date: 2021-02-15 Release date: 2021-04-21 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (3.19 Å) Cite: Extracellular cap domain is an essential component of the TRPV1 gating mechanism. Nat Commun, 12, 2021
7LR0	Structure of squirrel TRPV1 in complex with capsaicin Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, (6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide, Osm-9-like TRP channel 1, ... Authors: Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. Deposit date: 2021-02-15 Release date: 2021-04-21 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (3.81 Å) Cite: Extracellular cap domain is an essential component of the TRPV1 gating mechanism. Nat Commun, 12, 2021
7LQZ	Structure of squirrel TRPV1 in complex with RTX Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Osm-9-like TRP channel 1, SODIUM ION, ... Authors: Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. Deposit date: 2021-02-15 Release date: 2021-04-21 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (3.41 Å) Cite: Extracellular cap domain is an essential component of the TRPV1 gating mechanism. Nat Commun, 12, 2021
7LPA	Cryo-EM structure of full-length TRPV1 with capsaicin at 4 degrees Celsius Descriptor: (6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol, ... Authors: Kwon, D.H, Zhang, F, Suo, Y, Lee, S.-Y. Deposit date: 2021-02-11 Release date: 2021-07-28 Method: ELECTRON MICROSCOPY (3.37 Å) Cite: Heat-dependent opening of TRPV1 in the presence of capsaicin. Nat.Struct.Mol.Biol., 28, 2021
7LPE	Cryo-EM structure of full-length TRPV1 with capsaicin at 48 degrees Celsius, in an open state, class 1 Descriptor: (6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Transient receptor potential cation channel subfamily V member 1, ... Authors: Kwon, D.H, Zhang, F, Suo, Y, Lee, S.-Y. Deposit date: 2021-02-11 Release date: 2021-07-28 Method: ELECTRON MICROSCOPY (3.72 Å) Cite: Heat-dependent opening of TRPV1 in the presence of capsaicin. Nat.Struct.Mol.Biol., 28, 2021
7LPB	Cryo-EM structure of full-length TRPV1 with capsaicin at 25 degrees Celsius Descriptor: (6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol, ... Authors: Kwon, D.H, Zhang, F, Suo, Y, Lee, S.-Y. Deposit date: 2021-02-11 Release date: 2021-07-28 Method: ELECTRON MICROSCOPY (3.54 Å) Cite: Heat-dependent opening of TRPV1 in the presence of capsaicin. Nat.Struct.Mol.Biol., 28, 2021
7LPD	Cryo-EM structure of full-length TRPV1 with capsaicin at 48 degrees Celsius, in an intermediate state, class 2 Descriptor: (6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Transient receptor potential cation channel subfamily V member 1, ... Authors: Kwon, D.H, Zhang, F, Suo, Y, Lee, S.-Y. Deposit date: 2021-02-11 Release date: 2021-07-28 Method: ELECTRON MICROSCOPY (3.55 Å) Cite: Heat-dependent opening of TRPV1 in the presence of capsaicin. Nat.Struct.Mol.Biol., 28, 2021
7LP9	Cryo-EM structure of full-length TRPV1 at 4 degrees Celsius Descriptor: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol, Phosphatidylinositol, ... Authors: Kwon, D.H, Zhang, F, Suo, Y, Lee, S.-Y. Deposit date: 2021-02-11 Release date: 2021-07-28 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (2.63 Å) Cite: Heat-dependent opening of TRPV1 in the presence of capsaicin. Nat.Struct.Mol.Biol., 28, 2021
7LPC	Cryo-EM structure of full-length TRPV1 at 48 degrees Celsius Descriptor: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol, Phosphatidylinositol, ... Authors: Kwon, D.H, Zhang, F, Suo, Y, Lee, S.-Y. Deposit date: 2021-02-11 Release date: 2021-07-28 Method: ELECTRON MICROSCOPY (3.06 Å) Cite: Heat-dependent opening of TRPV1 in the presence of capsaicin. Nat.Struct.Mol.Biol., 28, 2021
8SP8	Human TRP channel TRPV6 in cNW30 nanodiscs inhibited by tetrahydrocannabivarin (THCV) Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CALCIUM ION, CHLORIDE ION, ... Authors: Neuberger, A, Yelshanskaya, M.V, Nadezhdin, K.D, Sobolevsky, A.I. Deposit date: 2023-05-02 Release date: 2023-08-23 Method: ELECTRON MICROSCOPY (2.79 Å) Cite: Molecular pathway and structural mechanism of human oncochannel TRPV6 inhibition by the phytocannabinoid tetrahydrocannabivarin. Nat Commun, 14, 2023
8SWI	Crystal structure of legAS4 from Legionella pneumophila subsp. pneumophila with histone H3 (1-12)peptide Descriptor: Eukaryotic huntingtin interacting protein B, Histone H3 peptided, S-ADENOSYL-L-HOMOCYSTEINE Authors: Xu, C, Chung, I.Y.W, Cygler, M. Deposit date: 2023-05-18 Release date: 2023-12-27 Method: X-RAY DIFFRACTION (3 Å) Cite: The SET and ankyrin domains of the secreted Legionella pneumophila histone methyltransferase work together to modify host chromatin. Mbio, 14, 2023
7MIO	Mouse TRPV3 in cNW11 nanodiscs, open state at 42 degrees Celsius Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, SODIUM ION, Transient receptor potential cation channel subfamily V member 3 Authors: Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. Deposit date: 2021-04-17 Release date: 2021-07-21 Last modified: 2021-07-28 Method: ELECTRON MICROSCOPY (3.48 Å) Cite: Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel. Nat.Struct.Mol.Biol., 28, 2021
7MIJ	Mouse TRPV3 in MSP2N2 nanodiscs, closed state at 4 degrees Celsius Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, SODIUM ION, Transient receptor potential cation channel subfamily V member 3 Authors: Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. Deposit date: 2021-04-17 Release date: 2021-07-21 Last modified: 2021-07-28 Method: ELECTRON MICROSCOPY (1.98 Å) Cite: Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel. Nat.Struct.Mol.Biol., 28, 2021
7MIK	Mouse TRPV3 in MSP2N2 nanodiscs, closed state at 42 degrees Celsius Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, SODIUM ION, Transient receptor potential cation channel subfamily V member 3 Authors: Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. Deposit date: 2021-04-17 Release date: 2021-07-21 Last modified: 2021-07-28 Method: ELECTRON MICROSCOPY (3.12 Å) Cite: Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel. Nat.Struct.Mol.Biol., 28, 2021
7MIN	Mouse TRPV3 in cNW11 nanodiscs, closed state at 42 degrees Celsius Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, SODIUM ION, Transient receptor potential cation channel subfamily V member 3 Authors: Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. Deposit date: 2021-04-17 Release date: 2021-07-21 Last modified: 2021-07-28 Method: ELECTRON MICROSCOPY (3.09 Å) Cite: Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel. Nat.Struct.Mol.Biol., 28, 2021
7MIM	Mouse TRPV3 in cNW11 nanodiscs, closed state at 4 degrees Celsius Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, SODIUM ION, Transient receptor potential cation channel subfamily V member 3 Authors: Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. Deposit date: 2021-04-17 Release date: 2021-07-21 Last modified: 2021-07-28 Method: ELECTRON MICROSCOPY (3.42 Å) Cite: Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel. Nat.Struct.Mol.Biol., 28, 2021
7MIL	Mouse TRPV3 in MSP2N2 nanodiscs, sensitized state at 42 degrees Celsius Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, SODIUM ION, Transient receptor potential cation channel subfamily V member 3 Authors: Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. Deposit date: 2021-04-17 Release date: 2021-07-21 Last modified: 2021-07-28 Method: ELECTRON MICROSCOPY (3.86 Å) Cite: Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel. Nat.Struct.Mol.Biol., 28, 2021
8SR6	Crystal structure of legAS4 from Legionella pneumophila subsp. pneumophila with histone H3 (3-17)peptide Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Eukaryotic huntingtin interacting protein B, ... Authors: Xu, C, Chung, I.Y.W, Cygler, M. Deposit date: 2023-05-05 Release date: 2024-03-13 Method: X-RAY DIFFRACTION (2.22 Å) Cite: Histone methyltransferase activity of the secreted Legionella pneumophila SET-domain effector RomA/LegAS4 depends on its ankyrin domain To Be Published
8T0Y	TRPV1 in nanodisc bound with one LPA in one monomer Descriptor: (2R)-2-hydroxy-3-(phosphonooxy)propyl tetradecanoate, (2R)-3-{[(R)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctadecanoate, SODIUM ION, ... Authors: Arnold, W.R, Cheng, Y. Deposit date: 2023-06-01 Release date: 2024-05-08 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Structural basis of TRPV1 modulation by endogenous bioactive lipids. Nat.Struct.Mol.Biol., 2024

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