6C3A
 
 | | O2-, PLP-dependent L-arginine hydroxylase RohP 4-hydroxy-2-ketoarginine complex | | Descriptor: | (4S)-5-carbamimidamido-4-hydroxy-2-oxopentanoic acid, 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Hedges, J.B, Ryan, K.S. | | Deposit date: | 2018-01-09 | | Release date: | 2018-03-07 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.53 Å) | | Cite: | Snapshots of the Catalytic Cycle of an O2, Pyridoxal Phosphate-Dependent Hydroxylase.
ACS Chem. Biol., 13, 2018
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6C3C
 | | PLP-dependent L-arginine hydroxylase RohP quinonoid I complex | | Descriptor: | (2E)-5-carbamimidamido-2-{[(Z)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4(1H)-ylidene}methyl]imino}pentanoic acid, 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Hedges, J.B, Ryan, K.S. | | Deposit date: | 2018-01-09 | | Release date: | 2018-03-07 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Snapshots of the Catalytic Cycle of an O2, Pyridoxal Phosphate-Dependent Hydroxylase.
ACS Chem. Biol., 13, 2018
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4J8L
 | | CRYSTAL STRUCTURE OF THE PYRIDOXAL-5'-PHOSPHATE DEPENDENT protein YhfS from Escherichia coli | | Descriptor: | ACETIC ACID, DI(HYDROXYETHYL)ETHER, NICKEL (II) ION, ... | | Authors: | Fedorov, A.A, Fedorov, E.V, Xiang, D.F, Raushel, F.M, Almo, S.C. | | Deposit date: | 2013-02-14 | | Release date: | 2014-03-05 | | Method: | X-RAY DIFFRACTION (1.651 Å) | | Cite: | Crystal structure of the pyridoxal-5'-phosphate dependent protein yhfs from escherichia coli
To be Published
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4M2J
 | | Crystal structure of PLP-dependent cyclase OrfR in complex with Au | | Descriptor: | Aminotransferase, GOLD ION, PYRIDOXAL-5'-PHOSPHATE | | Authors: | Chang, C.Y, Liu, Y.C, Lyu, S.Y, Wu, C.C, Li, T.L. | | Deposit date: | 2013-08-05 | | Release date: | 2014-06-18 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.95 Å) | | Cite: | Biosynthesis of streptolidine involved two unexpected intermediates produced by a dihydroxylase and a cyclase through unusual mechanisms.
Angew.Chem.Int.Ed.Engl., 53, 2014
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6DNA
 | | Crystal structure of T110A mutant human Glutamate oxaloacetate transaminase 1 (GOT1) | | Descriptor: | Aspartate aminotransferase, cytoplasmic, PYRIDOXAL-5'-PHOSPHATE, ... | | Authors: | Assar, Z, Holt, M.C, Stein, A.J, Lairson, L, Lyssiotis, C.A. | | Deposit date: | 2018-06-06 | | Release date: | 2018-11-14 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors.
Biochemistry, 57, 2018
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3K7Y
 | | Aspartate Aminotransferase of Plasmodium falciparum | | Descriptor: | ACETATE ION, Aspartate aminotransferase, PYRIDOXAL-5'-PHOSPHATE | | Authors: | Groves, M.R, Jordanova, R, Jain, R, Wrenger, C, Muller, I.B. | | Deposit date: | 2009-10-13 | | Release date: | 2010-10-13 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Specific Inhibition of the Aspartate Aminotransferase of Plasmodium falciparum.
J.Mol.Biol., 405, 2011
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3HQT
 | | PLP-Dependent Acyl-CoA Transferase CqsA | | Descriptor: | CAI-1 autoinducer synthase, PYRIDOXAL-5'-PHOSPHATE | | Authors: | Kelly, R.C, Jeffrey, P.D, Hughson, F.M. | | Deposit date: | 2009-06-08 | | Release date: | 2009-10-20 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | The Vibrio cholerae quorum-sensing autoinducer CAI-1: analysis of the biosynthetic enzyme CqsA.
Nat.Chem.Biol., 5, 2009
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3PAA
 | | Mechanism of inactivation of E. coli aspartate aminotransferase by (S)-4-amino-4,5-dihydro-2-furancarboxylic acid (S-ADFA) pH 8.0 | | Descriptor: | 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, 4-aminofuran-2-carboxylic acid, Aspartate aminotransferase, ... | | Authors: | Liu, D, Pozharski, E, Fu, M, Silverman, R.B, Ringe, D. | | Deposit date: | 2010-10-19 | | Release date: | 2010-12-01 | | Last modified: | 2019-07-17 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Mechanism of inactivation of Escherichia coli aspartate aminotransferase by (S)-4-amino-4,5-dihydro-2-furancarboxylic acid .
Biochemistry, 49, 2010
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3KKI
 | | PLP-Dependent Acyl-CoA transferase CqsA | | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, CAI-1 autoinducer synthase, MAGNESIUM ION, ... | | Authors: | Kelly, R.C, Jeffrey, P.D, Hughson, F.M. | | Deposit date: | 2009-11-05 | | Release date: | 2009-11-24 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | The Vibrio cholerae quorum-sensing autoinducer CAI-1: analysis of the biosynthetic enzyme CqsA.
Nat.Chem.Biol., 5, 2009
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4M2K
 | | Crystal structure of PLP-dependent cyclase OrfR in complex with PLP | | Descriptor: | Aminotransferase, PYRIDOXAL-5'-PHOSPHATE | | Authors: | Chang, C.Y, Liu, Y.C, Lyu, S.Y, Wu, C.C, Li, T.L. | | Deposit date: | 2013-08-05 | | Release date: | 2014-06-18 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Biosynthesis of streptolidine involved two unexpected intermediates produced by a dihydroxylase and a cyclase through unusual mechanisms.
Angew.Chem.Int.Ed.Engl., 53, 2014
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4MY5
 | | Crystal structure of the aromatic amino acid aminotransferase from Streptococcus mutants | | Descriptor: | Putative amino acid aminotransferase | | Authors: | Cong, X, Li, X, Ge, J, Feng, Y, Feng, X, Li, S. | | Deposit date: | 2013-09-27 | | Release date: | 2014-10-01 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.194 Å) | | Cite: | Crystal structure of the aromatic-amino-acid aminotransferase from Streptococcus mutans.
Acta Crystallogr.,Sect.F, 75, 2019
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3PA9
 | | Mechanism of inactivation of E. coli aspartate aminotransferase by (S)-4-amino-4,5-dihydro-2-furancarboxylic acid (S-ADFA) pH 7.5 | | Descriptor: | 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, 4-aminofuran-2-carboxylic acid, Aspartate aminotransferase, ... | | Authors: | Liu, D, Pozharski, E, Fu, M, Silverman, R.B, Ringe, D. | | Deposit date: | 2010-10-19 | | Release date: | 2010-12-01 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Mechanism of inactivation of Escherichia coli aspartate aminotransferase by (S)-4-amino-4,5-dihydro-2-furancarboxylic acid .
Biochemistry, 49, 2010
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3P1T
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3PD6
 | | Crystal structure of mouse mitochondrial aspartate aminotransferase, a newly identified kynurenine aminotransferase-IV | | Descriptor: | (2S)-2-amino-4-(2-aminophenyl)-4-oxobutanoic acid, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, Aspartate aminotransferase, ... | | Authors: | Han, Q, Robinson, H, Cai, T, Tagle, D.A, Li, J. | | Deposit date: | 2010-10-22 | | Release date: | 2010-11-10 | | Last modified: | 2023-12-06 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Biochemical and structural characterization of mouse mitochondrial aspartate aminotransferase, a newly identified kynurenine aminotransferase-IV.
Biosci.Rep., 31, 2011
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3PDB
 | | Crystal structure of mouse mitochondrial aspartate aminotransferase in complex with oxaloacetic acid | | Descriptor: | 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, Aspartate aminotransferase, mitochondrial, ... | | Authors: | Han, Q, Robinson, H, Cai, T, Tagle, D.A, Li, J. | | Deposit date: | 2010-10-22 | | Release date: | 2010-11-10 | | Last modified: | 2023-12-06 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Biochemical and structural characterization of mouse mitochondrial aspartate aminotransferase, a newly identified kynurenine aminotransferase-IV.
Biosci.Rep., 31, 2011
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1X28
 | | Crystal Structure of e.coli AspAT complexed with N-phosphopyridoxyl-L-glutamic acid | | Descriptor: | Aspartate aminotransferase, N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)-L-glutamic acid | | Authors: | Goto, M. | | Deposit date: | 2005-04-21 | | Release date: | 2005-06-14 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Binding of C5-dicarboxylic substrate to aspartate aminotransferase: implications for the conformational change at the transaldimination step.
Biochemistry, 44, 2005
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1WST
 | | Crystal structure of multiple substrate aminotransferase (MsAT) from Thermococcus profundus | | Descriptor: | PYRIDOXAL-5'-PHOSPHATE, multiple substrate aminotransferase | | Authors: | Lee, W.C, Manabe, F, Nemoto, N, Tamakoshi, M, Tanokura, M, Yamagishi, A. | | Deposit date: | 2004-11-10 | | Release date: | 2005-10-25 | | Last modified: | 2021-11-10 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Crystal structure of multiple substrate aminotransferase (MsAT) from Thermococcus profundus
To be Published
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1X29
 | | Crystal Structure of e.coli AspAT complexed with N-phosphopyridoxyl-2-methyl-L-glutamic acid | | Descriptor: | Aspartate aminotransferase, N-({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)-2-METHYL-L-GLUTAMIC ACID | | Authors: | Goto, M. | | Deposit date: | 2005-04-21 | | Release date: | 2005-06-14 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Binding of C5-dicarboxylic substrate to aspartate aminotransferase: implications for the conformational change at the transaldimination step.
Biochemistry, 44, 2005
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1YNU
 | | Crystal structure of apple ACC synthase in complex with L-vinylglycine | | Descriptor: | 1-aminocyclopropane-1-carboxylate synthase, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-[O-PHOSPHONOPYRIDOXYL]-AMINO- BUTYRIC ACID, ... | | Authors: | Capitani, G, Tschopp, M, Eliot, A.C, Kirsch, J.F, Grutter, M.G. | | Deposit date: | 2005-01-25 | | Release date: | 2005-05-03 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Structure of ACC synthase inactivated by the mechanism-based inhibitor L-vinylglycine.
Febs Lett., 579, 2005
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1YOO
 | | ASPARTATE AMINOTRANSFERASE MUTANT ATB17 WITH ISOVALERIC ACID | | Descriptor: | ASPARTATE AMINOTRANSFERASE, ISOVALERIC ACID, PYRIDOXAL-5'-PHOSPHATE | | Authors: | Oue, S, Okamoto, A, Yano, T, Kagamiyama, H. | | Deposit date: | 1998-06-26 | | Release date: | 1999-02-02 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Redesigning the substrate specificity of an enzyme by cumulative effects of the mutations of non-active site residues.
J.Biol.Chem., 274, 1999
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1YAA
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1YIY
 | | Aedes aegypti kynurenine aminotransferase | | Descriptor: | 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, BROMIDE ION, kynurenine aminotransferase; glutamine transaminase K | | Authors: | Han, Q, Gao, Y.G, Robinson, H, Ding, H, Wilson, S, Li, J. | | Deposit date: | 2005-01-13 | | Release date: | 2005-05-10 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structures of Aedes aegypti kynurenine aminotransferase.
FEBS J., 272, 2005
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1YIZ
 | | Aedes aegypti kynurenine aminotrasferase | | Descriptor: | BROMIDE ION, kynurenine aminotransferase; glutamine transaminase | | Authors: | Han, Q, Gao, Y.G, Robinson, H, Ding, H, Wilson, S, Li, J. | | Deposit date: | 2005-01-13 | | Release date: | 2005-05-10 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Crystal structures of Aedes aegypti kynurenine aminotransferase.
FEBS J., 272, 2005
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2AAT
 | | 2.8-ANGSTROMS-RESOLUTION CRYSTAL STRUCTURE OF AN ACTIVE-SITE MUTANT OF ASPARTATE AMINOTRANSFERASE FROM ESCHERICHIA COLI | | Descriptor: | 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, ASPARTATE AMINOTRANSFERASE, SULFATE ION | | Authors: | Smith, D, Almo, S.C, Toney, M, Ringe, D. | | Deposit date: | 1989-05-30 | | Release date: | 1989-10-15 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | 2.8-A-resolution crystal structure of an active-site mutant of aspartate aminotransferase from Escherichia coli.
Biochemistry, 28, 1989
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1XI9
 | | Alanine aminotransferase from Pyrococcus furiosus Pfu-1397077-001 | | Descriptor: | PYRIDOXAL-5'-PHOSPHATE, putative transaminase | | Authors: | Zhou, W, Tempel, W, Shah, A, Chen, L, Liu, Z.-J, Lee, D, Lin, D, Chang, S.-H, Brereton, P.S, Izumi, M, Jenney Jr, F.E, Lee, H.-S, Poole II, F.L, Shah, C, Sugar, F.J, Arendall III, W.B, Richardson, J.S, Richardson, D.C, Rose, J.P, Adams, M.W.W, Wang, B.-C, Southeast Collaboratory for Structural Genomics (SECSG) | | Deposit date: | 2004-09-21 | | Release date: | 2004-11-23 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.33 Å) | | Cite: | Alanine aminotransferase from Pyrococcus furiosus Pfu-1397077-001
To be published
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