8T1I
 
 | | Atomic model of the mammalian Mediator complex with MED26 subunit | | Descriptor: | Mediator of RNA polymerase II transcription subunit 1, Mediator of RNA polymerase II transcription subunit 10, Mediator of RNA polymerase II transcription subunit 11, ... | | Authors: | Zhao, H, Asturias, F. | | Deposit date: | 2023-06-02 | | Release date: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (4.68 Å) | | Cite: | An IDR-dependent mechanism for nuclear receptor control of Mediator interaction with RNA polymerase II
To Be Published
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7SGR
 | | Structure of hemolysin A secretion system HlyB/D complex | | Descriptor: | Alpha-hemolysin translocation ATP-binding protein HlyB, Membrane fusion protein (MFP) family protein,Hemolysin secretion protein D, chromosomal, ... | | Authors: | Zhao, H, Chen, J. | | Deposit date: | 2021-10-07 | | Release date: | 2022-09-14 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | The hemolysin A secretion system is a multi-engine pump containing three ABC transporters.
Cell, 185, 2022
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4U7U
 | | Crystal structure of RNA-guided immune Cascade complex from E.coli | | Descriptor: | CRISPR system Cascade subunit CasA, CRISPR system Cascade subunit CasB, CRISPR system Cascade subunit CasC, ... | | Authors: | Zhao, H, Sheng, G, Wang, J, Wang, M, Bunkoczi, G, Gong, W, Wei, Z, Wang, Y. | | Deposit date: | 2014-07-31 | | Release date: | 2014-08-27 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (3.003 Å) | | Cite: | Crystal structure of the RNA-guided immune surveillance Cascade complex in Escherichia coli
Nature, 515, 2014
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6PLK
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1P33
 | | Pteridine reductase from Leishmania tarentolae complex with NADPH and MTX | | Descriptor: | METHOTREXATE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Pteridine reductase 1 | | Authors: | Zhao, H, Bray, T, Ouellette, M, Zhao, M, Ferre, R.A, Matthews, D, Whiteley, J.M, Varughese, K.I. | | Deposit date: | 2003-04-16 | | Release date: | 2003-09-02 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.86 Å) | | Cite: | Structure of pteridine reductase (PTR1) from Leishmania tarentolae.
Acta Crystallogr.,Sect.D, 59, 2003
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5KVG
 | | Zika specific antibody, ZV-67, bound to ZIKA envelope DIII | | Descriptor: | CHLORIDE ION, ZIKA Envelope DIII, ZV-67 Antibody Fab Heavy Chain, ... | | Authors: | Zhao, H, Nelson, C.A, Fremont, D.H, Center for Structural Genomics of Infectious Diseases (CSGID) | | Deposit date: | 2016-07-14 | | Release date: | 2016-08-03 | | Last modified: | 2016-08-24 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Structural Basis of Zika Virus-Specific Antibody Protection.
Cell, 166, 2016
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5KVF
 | | Zika specific antibody, ZV-64, bound to ZIKA envelope DIII | | Descriptor: | GLYCEROL, ZV-64 Antibody Fab Heavy Chain, ZV-64 Antibody Fab Light Chain, ... | | Authors: | Zhao, H, Nelson, C.A, Fremont, D.H, Center for Structural Genomics of Infectious Diseases (CSGID) | | Deposit date: | 2016-07-14 | | Release date: | 2016-08-03 | | Last modified: | 2016-08-24 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Structural Basis of Zika Virus-Specific Antibody Protection.
Cell, 166, 2016
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5KVE
 | | Zika specific antibody, ZV-48, bound to ZIKA envelope DIII | | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, Genome polyprotein, ... | | Authors: | Zhao, H, Nelson, C.A, Fremont, D.H, Center for Structural Genomics of Infectious Diseases (CSGID) | | Deposit date: | 2016-07-14 | | Release date: | 2016-08-10 | | Last modified: | 2019-12-25 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structural Basis of Zika Virus-Specific Antibody Protection.
Cell, 166, 2016
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5KVD
 | | Zika specific antibody, ZV-2, bound to ZIKA envelope DIII | | Descriptor: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, SODIUM ION, ... | | Authors: | Zhao, H, Nelson, C.A, Fremont, D.H, Center for Structural Genomics of Infectious Diseases (CSGID) | | Deposit date: | 2016-07-14 | | Release date: | 2016-08-03 | | Last modified: | 2016-08-24 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Structural Basis of Zika Virus-Specific Antibody Protection.
Cell, 166, 2016
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5L35
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1LQ1
 | | DNA Complexed Structure of the Key Transcription Factor Initiating Development in Sporulation Bacteria | | Descriptor: | 5'-D(*AP*CP*AP*AP*AP*AP*TP*TP*CP*GP*AP*CP*AP*CP*GP*A)-3', 5'-D(*TP*TP*CP*GP*TP*GP*TP*CP*GP*AP*AP*TP*TP*TP*TP*G)-3', Stage 0 sporulation protein A | | Authors: | Zhao, H, Msadek, T, Zapf, J, Madhusudan, Hoch, J.A, Varughese, K.I. | | Deposit date: | 2002-05-08 | | Release date: | 2002-08-23 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | DNA complexed structure of the key transcription factor initiating development in sporulating bacteria.
Structure, 10, 2002
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7UKD
 | | Human Kv4.2-KChIP2 channel complex in an inactivated state, class 2, transmembrane region | | Descriptor: | POTASSIUM ION, Potassium voltage-gated channel subfamily D member 2 | | Authors: | Zhao, H, Dai, Y, Lee, C.H. | | Deposit date: | 2022-04-01 | | Release date: | 2022-06-29 | | Last modified: | 2024-02-14 | | Method: | ELECTRON MICROSCOPY (2.88 Å) | | Cite: | Activation and closed-state inactivation mechanisms of the human voltage-gated K V 4 channel complexes.
Mol.Cell, 82, 2022
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7UKC
 | | Human Kv4.2-KChIP2 channel complex in an inactivated state, class 1, transmembrane region | | Descriptor: | POTASSIUM ION, Potassium voltage-gated channel subfamily D member 2 | | Authors: | Zhao, H, Dai, Y, Lee, C.H. | | Deposit date: | 2022-04-01 | | Release date: | 2022-06-29 | | Last modified: | 2024-02-14 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Activation and closed-state inactivation mechanisms of the human voltage-gated K V 4 channel complexes.
Mol.Cell, 82, 2022
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7UKF
 | | Human Kv4.2-KChIP2 channel complex in a putative resting state, transmembrane region | | Descriptor: | MERCURY (II) ION, POTASSIUM ION, Potassium voltage-gated channel subfamily D member 2 | | Authors: | Zhao, H, Dai, Y, Lee, C.H. | | Deposit date: | 2022-04-01 | | Release date: | 2022-06-29 | | Last modified: | 2024-02-14 | | Method: | ELECTRON MICROSCOPY (3.02 Å) | | Cite: | Activation and closed-state inactivation mechanisms of the human voltage-gated K V 4 channel complexes.
Mol.Cell, 82, 2022
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7UK5
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7UKE
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7UKG
 | | Human Kv4.2-KChIP2-DPP6 channel complex in an open state, transmembrane region | | Descriptor: | Dipeptidyl-peptidase 6, POTASSIUM ION, Potassium voltage-gated channel subfamily D member 2 | | Authors: | Zhao, H, Dai, Y, Lee, C.H. | | Deposit date: | 2022-04-01 | | Release date: | 2022-06-29 | | Last modified: | 2024-02-14 | | Method: | ELECTRON MICROSCOPY (2.24 Å) | | Cite: | Activation and closed-state inactivation mechanisms of the human voltage-gated K V 4 channel complexes.
Mol.Cell, 82, 2022
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7UKH
 | | Human Kv4.2-KChIP2-DPP6 channel complex in an open state, intracellular region | | Descriptor: | CALCIUM ION, Isoform 2 of Kv channel-interacting protein 2, Potassium voltage-gated channel subfamily D member 2, ... | | Authors: | Zhao, H, Dai, Y, Lee, C.H. | | Deposit date: | 2022-04-01 | | Release date: | 2022-06-29 | | Last modified: | 2024-02-14 | | Method: | ELECTRON MICROSCOPY (2.33 Å) | | Cite: | Activation and closed-state inactivation mechanisms of the human voltage-gated K V 4 channel complexes.
Mol.Cell, 82, 2022
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6W1S
 | | Atomic model of the mammalian Mediator complex | | Descriptor: | Mediator of RNA polymerase II transcription subunit 1, Mediator of RNA polymerase II transcription subunit 10, Mediator of RNA polymerase II transcription subunit 11, ... | | Authors: | Zhao, H, Young, N, Asturias, F. | | Deposit date: | 2020-03-04 | | Release date: | 2021-03-10 | | Method: | ELECTRON MICROSCOPY (4.02 Å) | | Cite: | A Pliable Mediator Acts as a Functional Rather Than an Architectural Bridge between Promoters and Enhancers.
Cell, 178, 2019
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6VWS
 | | Hexamer of Helical HIV capsid by RASTR method | | Descriptor: | HIV capsid protein | | Authors: | Zhao, H, Iqbal, N, Asturias, F, Kvaratskhelia, M, Vanblerkom, P. | | Deposit date: | 2020-02-20 | | Release date: | 2020-10-21 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (6.08 Å) | | Cite: | Structural and mechanistic bases for a potent HIV-1 capsid inhibitor.
Science, 370, 2020
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8SNN
 | | Structure of mature human ADAM17/iRhom2 sheddase complex, conformation 1 | | Descriptor: | CALCIUM ION, Disintegrin and metalloproteinase domain-containing protein 17, Inactive rhomboid protein 2 | | Authors: | Zhao, H, Dai, Y, Wang, Y, Lee, C.H. | | Deposit date: | 2023-04-27 | | Release date: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (2.32 Å) | | Cite: | Structure of mature human ADAM17/iRhom2 sheddase complex, conformation 1
To Be Published
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8SNL
 | | Structure of human ADAM17/iRhom2 sheddase complex | | Descriptor: | CALCIUM ION, Disintegrin and metalloproteinase domain-containing protein 17, Inactive rhomboid protein 2, ... | | Authors: | Zhao, H, Dai, Y, Wang, Y, Lee, C.H. | | Deposit date: | 2023-04-27 | | Release date: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (2.78 Å) | | Cite: | Structure of human ADAM17/iRhom2 sheddase complex
To Be Published
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8SNM
 | | Structure of mature human ADAM17/iRhom2 sheddase complex in complex with ADAM17 prodomain | | Descriptor: | CALCIUM ION, Disintegrin and metalloproteinase domain-containing protein 17, Disintegrin and metalloproteinase domain-containing protein 17 propeptide, ... | | Authors: | Zhao, H, Dai, Y, Wang, Y, Lee, C.H. | | Deposit date: | 2023-04-27 | | Release date: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (3.84 Å) | | Cite: | Structure of mature human ADAM17/iRhom2 sheddase complex in complex with ADAM17 prodomain
To Be Published
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8SNO
 | | Structure of mature human ADAM17/iRhom2 sheddase complex, conformation 2 | | Descriptor: | CALCIUM ION, Disintegrin and metalloproteinase domain-containing protein 17, Inactive rhomboid protein 2 | | Authors: | Zhao, H, Dai, Y, Wang, Y, Lee, C.H. | | Deposit date: | 2023-04-27 | | Release date: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (2.78 Å) | | Cite: | Structure of mature human ADAM17/iRhom2 sheddase complex, conformation 2
To Be Published
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1XBO
 | | PTP1B complexed with Isoxazole Carboxylic Acid | | Descriptor: | 5-(3-{3-[3-HYDROXY-2-(METHOXYCARBONYL)PHENOXY]PROPENYL}PHENYL)-4-(HYDROXYMETHYL)ISOXAZOLE-3-CARBOXYLIC ACID, Protein-tyrosine phosphatase, non-receptor type 1 | | Authors: | Zhao, H, Liu, G, Xin, Z, Serby, M, Pei, Z, Szczepankiewicz, B.G, Hajduk, P.J, Abad-Zapatero, C, Hutchins, C.W, Lubben, T.H, Ballaron, S.J, Hassach, D.L, Kaszubska, W, Rondinone, C.M, Trevillyan, J.M, Jirousek, M.R. | | Deposit date: | 2004-08-31 | | Release date: | 2004-10-19 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Isoxazole carboxylic acids as protein tyrosine phosphatase 1B (PTP1B) inhibitors.
Bioorg.Med.Chem.Lett., 14, 2004
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