1XBO
PTP1B complexed with Isoxazole Carboxylic Acid
Summary for 1XBO
Entry DOI | 10.2210/pdb1xbo/pdb |
Related | 1NL9 1NNY 1NO6 1NZZ 1ONY 1ONZ |
Descriptor | Protein-tyrosine phosphatase, non-receptor type 1, 5-(3-{3-[3-HYDROXY-2-(METHOXYCARBONYL)PHENOXY]PROPENYL}PHENYL)-4-(HYDROXYMETHYL)ISOXAZOLE-3-CARBOXYLIC ACID (3 entities in total) |
Functional Keywords | protein tyrosine phosphatase 1b, ptp1b, isoxazole carboxylic acid, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P18031 |
Total number of polymer chains | 1 |
Total formula weight | 37791.03 |
Authors | Zhao, H.,Liu, G.,Xin, Z.,Serby, M.,Pei, Z.,Szczepankiewicz, B.G.,Hajduk, P.J.,Abad-Zapatero, C.,Hutchins, C.W.,Lubben, T.H.,Ballaron, S.J.,Hassach, D.L.,Kaszubska, W.,Rondinone, C.M.,Trevillyan, J.M.,Jirousek, M.R. (deposition date: 2004-08-31, release date: 2004-10-19, Last modification date: 2023-08-23) |
Primary citation | Zhao, H.,Liu, G.,Xin, Z.,Serby, M.D.,Pei, Z.,Szczepankiewicz, B.G.,Hajduk, P.J.,Abad-Zapatero, C.,Hutchins, C.W.,Lubben, T.H.,Ballaron, S.J.,Haasch, D.L.,Kaszubska, W.,Rondinone, C.M.,Trevillyan, J.M.,Jirousek, M.R. Isoxazole carboxylic acids as protein tyrosine phosphatase 1B (PTP1B) inhibitors. Bioorg.Med.Chem.Lett., 14:5543-5546, 2004 Cited by PubMed: 15482920DOI: 10.1016/j.bmcl.2004.08.063 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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