1F9V
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![BU of 1f9v by Molmil](/molmil-images/mine/1f9v) | CRYSTAL STRUCTURES OF MUTANTS REVEAL A SIGNALLING PATHWAY FOR ACTIVATION OF THE KINESIN MOTOR ATPASE | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KAR3, MAGNESIUM ION | Authors: | Yun, M, Zhang, X, Park, C.G, Park, H.W, Endow, S.A. | Deposit date: | 2000-07-11 | Release date: | 2001-06-13 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | A structural pathway for activation of the kinesin motor ATPase. EMBO J., 20, 2001
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3TYE
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![BU of 3tye by Molmil](/molmil-images/mine/3tye) | Dihydropteroate Synthase in complex with DHP-STZ | Descriptor: | 2-amino-6-methylidene-6,7-dihydropteridin-4(3H)-one, 4-amino-N-(1,3-thiazol-2-yl)benzenesulfonamide, 4-{[(2-amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl]amino}-N-(1,3-thiazol-2-yl)benzenesulfonamide, ... | Authors: | Yun, M.-K, White, S.W. | Deposit date: | 2011-09-24 | Release date: | 2012-03-14 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Catalysis and sulfa drug resistance in dihydropteroate synthase. Science, 335, 2012
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3TYC
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![BU of 3tyc by Molmil](/molmil-images/mine/3tyc) | Dihydropteroate Synthase in complex with DHP+ | Descriptor: | 2-amino-6-methylidene-6,7-dihydropteridin-4(3H)-one, Dihydropteroate synthase, SULFATE ION | Authors: | Yun, M.-K, White, S.W. | Deposit date: | 2011-09-24 | Release date: | 2012-03-14 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.303 Å) | Cite: | Catalysis and sulfa drug resistance in dihydropteroate synthase. Science, 335, 2012
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3TYD
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![BU of 3tyd by Molmil](/molmil-images/mine/3tyd) | Dihydropteroate Synthase in complex with PPi and DHP+ | Descriptor: | 2-amino-6-methylidene-6,7-dihydropteridin-4(3H)-one, Dihydropteroate synthase, PYROPHOSPHATE 2-, ... | Authors: | Yun, M.-K, White, S.W. | Deposit date: | 2011-09-24 | Release date: | 2012-03-14 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Catalysis and sulfa drug resistance in dihydropteroate synthase. Science, 335, 2012
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3TYU
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![BU of 3tyu by Molmil](/molmil-images/mine/3tyu) | |
3V5O
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![BU of 3v5o by Molmil](/molmil-images/mine/3v5o) | Structural and Mechanistic Studies of Catalysis and Sulfa Drug Resistance in Dihydropteroate Synthase | Descriptor: | Dihydropteroate synthase, SULFATE ION | Authors: | Yun, M, Wu, Y, Li, Z, Zhao, Y, Waddell, M.B, Ferreira, A.M, Lee, R.E, Bashford, D, White, S.W. | Deposit date: | 2011-12-16 | Release date: | 2012-03-14 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Catalysis and sulfa drug resistance in dihydropteroate synthase. Science, 335, 2012
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3MK6
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![BU of 3mk6 by Molmil](/molmil-images/mine/3mk6) | Substrate and Inhibitor Binding to Pank | Descriptor: | ACETYL COENZYME *A, GLYCEROL, Pantothenate kinase 3 | Authors: | Yun, M.-K, White, S.W. | Deposit date: | 2010-04-14 | Release date: | 2010-09-15 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | Modulation of Pantothenate Kinase 3 Activity by Small Molecules that Interact with the Substrate/Allosteric Regulatory Domain. Chem.Biol., 17, 2010
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1M7E
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![BU of 1m7e by Molmil](/molmil-images/mine/1m7e) | Crystal structure of the phosphotyrosine binding domain(PTB) of mouse Disabled 2(Dab2):implications for Reeling signaling | Descriptor: | Disabled homolog 2, NGYENPTYK peptide | Authors: | Yun, M, Keshvara, L, Park, C.-G, Zhang, Y.-M, Dickerson, J.B, Zheng, J, Rock, C.O, Curran, T, Park, H.-W. | Deposit date: | 2002-07-19 | Release date: | 2003-08-05 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Crystal structures of the Dab homology domains of mouse disabled 1 and 2 J.Biol.Chem., 278, 2003
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1F9U
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![BU of 1f9u by Molmil](/molmil-images/mine/1f9u) | CRYSTAL STRUCTURES OF MUTANTS REVEAL A SIGNALLING PATHWAY FOR ACTIVATION OF THE KINESIN MOTOR ATPASE | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KAR3, MAGNESIUM ION | Authors: | Yun, M, Zhang, X, Park, C.G, Park, H.W, Endow, S.A. | Deposit date: | 2000-07-11 | Release date: | 2001-06-13 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | A structural pathway for activation of the kinesin motor ATPase. EMBO J., 20, 2001
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1F9W
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![BU of 1f9w by Molmil](/molmil-images/mine/1f9w) | CRYSTAL STRUCTURES OF MUTANTS REVEAL A SIGNALLING PATHWAY FOR ACTIVATION OF THE KINESIN MOTOR ATPASE | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KAR3, MAGNESIUM ION | Authors: | Yun, M, Zhang, X, Park, C.G, Park, H.W, Endow, S.A. | Deposit date: | 2000-07-11 | Release date: | 2001-06-13 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | A structural pathway for activation of the kinesin motor ATPase. EMBO J., 20, 2001
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1F9T
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![BU of 1f9t by Molmil](/molmil-images/mine/1f9t) | CRYSTAL STRUCTURES OF KINESIN MUTANTS REVEAL A SIGNALLING PATHWAY FOR ACTIVATION OF THE MOTOR ATPASE | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KAR3, MAGNESIUM ION | Authors: | Yun, M, Zhang, X, Park, C.-G, Park, H.-W, Endow, S.A. | Deposit date: | 2000-07-11 | Release date: | 2001-06-13 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | A structural pathway for activation of the kinesin motor ATPase. EMBO J., 20, 2001
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3TYB
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![BU of 3tyb by Molmil](/molmil-images/mine/3tyb) | Dihydropteroate Synthase in complex with pHBA and DHP+ | Descriptor: | 2-amino-6-methylidene-6,7-dihydropteridin-4(3H)-one, Dihydropteroate synthase, P-HYDROXYBENZOIC ACID, ... | Authors: | Yun, M.-K, White, S.W. | Deposit date: | 2011-09-24 | Release date: | 2012-03-14 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Catalysis and sulfa drug resistance in dihydropteroate synthase. Science, 335, 2012
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4M5M
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![BU of 4m5m by Molmil](/molmil-images/mine/4m5m) | The Identification, Analysis and Structure-Based Development of Novel Inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase | Descriptor: | 2-amino-1,9-dihydro-6H-purine-6-thione, 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, CALCIUM ION, ... | Authors: | Yun, M, Hoagland, D, Kumar, G, Waddell, B, Rock, C.O, Lee, R.E, White, S.W. | Deposit date: | 2013-08-08 | Release date: | 2014-04-02 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.118 Å) | Cite: | The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase. Bioorg.Med.Chem., 22, 2014
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2P2N
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![BU of 2p2n by Molmil](/molmil-images/mine/2p2n) | Crystal Structure and Allosteric Regulation of the Cytoplasmic Escherichia coli L-Asparaginase I | Descriptor: | 1,2-ETHANEDIOL, ASPARAGINE, ASPARTIC ACID, ... | Authors: | Yun, M.-K, Nourse, A, White, S.W, Rock, C.O, Heath, R.J. | Deposit date: | 2007-03-07 | Release date: | 2007-05-15 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal Structure and Allosteric Regulation of the Cytoplasmic Escherichia colil-Asparaginase I J.Mol.Biol., 369, 2007
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4M5I
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![BU of 4m5i by Molmil](/molmil-images/mine/4m5i) | The Identification, Analysis and Structure-Based Development of Novel Inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase | Descriptor: | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 2-amino-8-{[2-(4-methylphenyl)-2-oxoethyl]sulfanyl}-1,7-dihydro-6H-purin-6-one, CALCIUM ION, ... | Authors: | Yun, M, Hoagland, D, Kumar, G, Waddell, B, Rock, C.O, Lee, R.E, White, S.W. | Deposit date: | 2013-08-08 | Release date: | 2014-04-02 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.08 Å) | Cite: | The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase. Bioorg.Med.Chem., 22, 2014
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4M5H
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![BU of 4m5h by Molmil](/molmil-images/mine/4m5h) | The Identification, Analysis and Structure-Based Development of Novel Inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase | Descriptor: | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 4-{[(2-amino-6-oxo-6,9-dihydro-1H-purin-8-yl)sulfanyl]methyl}benzonitrile, CALCIUM ION, ... | Authors: | Yun, M, Hoagland, D, Kumar, G, Waddell, B, Rock, C.O, Lee, R.E, White, S.W. | Deposit date: | 2013-08-08 | Release date: | 2014-04-02 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.11 Å) | Cite: | The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase. Bioorg.Med.Chem., 22, 2014
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4M5G
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![BU of 4m5g by Molmil](/molmil-images/mine/4m5g) | The Identification, Analysis and Structure-Based Development of Novel Inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase | Descriptor: | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 2-amino-8-[(2-oxo-2-phenylethyl)sulfanyl]-1,9-dihydro-6H-purin-6-one, CALCIUM ION, ... | Authors: | Yun, M, Hoagland, D, Kumar, G, Waddell, B, Rock, C.O, Lee, R.E, White, S.W. | Deposit date: | 2013-08-08 | Release date: | 2014-04-02 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.31 Å) | Cite: | The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase. Bioorg.Med.Chem., 22, 2014
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4M5N
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![BU of 4m5n by Molmil](/molmil-images/mine/4m5n) | The Identification, Analysis and Structure-Based Development of Novel Inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase | Descriptor: | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 6-amino-1,9-dihydro-2H-purine-2-thione, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ... | Authors: | Yun, M, Hoagland, D, Kumar, G, Waddell, B, Rock, C.O, Lee, R.E, White, S.W. | Deposit date: | 2013-08-08 | Release date: | 2014-04-02 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase. Bioorg.Med.Chem., 22, 2014
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4M5K
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![BU of 4m5k by Molmil](/molmil-images/mine/4m5k) | The Identification, Analysis and Structure-Based Development of Novel Inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase | Descriptor: | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 2-amino-8-{[2-(3-methylphenyl)-2-oxoethyl]sulfanyl}-1,9-dihydro-6H-purin-6-one, CALCIUM ION, ... | Authors: | Yun, M, Hoagland, D, Kumar, G, Waddell, B, Rock, C.O, Lee, R.E, White, S.W. | Deposit date: | 2013-08-08 | Release date: | 2014-04-02 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.296 Å) | Cite: | The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase. Bioorg.Med.Chem., 22, 2014
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4M5L
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![BU of 4m5l by Molmil](/molmil-images/mine/4m5l) | The Identification, Analysis and Structure-Based Development of Novel Inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase | Descriptor: | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 2-amino-8-{[2-(2-methylphenyl)-2-oxoethyl]sulfanyl}-1,7-dihydro-6H-purin-6-one, CALCIUM ION, ... | Authors: | Yun, M, Hoagland, D, Kumar, G, Waddell, B, Rock, C.O, Lee, R.E, White, S.W. | Deposit date: | 2013-08-08 | Release date: | 2014-04-02 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.094 Å) | Cite: | The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase. Bioorg.Med.Chem., 22, 2014
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4M5J
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![BU of 4m5j by Molmil](/molmil-images/mine/4m5j) | The Identification, Analysis and Structure-Based Development of Novel Inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase | Descriptor: | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 2-amino-8-{[2-(4-methoxyphenyl)-2-oxoethyl]sulfanyl}-1,9-dihydro-6H-purin-6-one, CHLORIDE ION, ... | Authors: | Yun, M, Hoagland, D, Kumar, G, Waddell, B, Rock, C.O, Lee, R.E, White, S.W. | Deposit date: | 2013-08-08 | Release date: | 2014-04-02 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.696 Å) | Cite: | The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase. Bioorg.Med.Chem., 22, 2014
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2P2D
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![BU of 2p2d by Molmil](/molmil-images/mine/2p2d) | Crystal Structure and Allosteric Regulation of the Cytoplasmic Escherichia coli L-Asparaginase I | Descriptor: | GLYCEROL, L-ASPARAGINASE I | Authors: | Yun, M.-K, Nourse, A, White, S.W, Rock, C.O, Heath, R.J. | Deposit date: | 2007-03-07 | Release date: | 2007-05-15 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Crystal Structure and Allosteric Regulation of the Cytoplasmic Escherichia colil-Asparaginase I J.Mol.Biol., 369, 2007
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3H2C
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![BU of 3h2c by Molmil](/molmil-images/mine/3h2c) | |
3H2N
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![BU of 3h2n by Molmil](/molmil-images/mine/3h2n) | Structural Studies of Pterin-Based Inhibitors of Dihydropteroate Synthase | Descriptor: | (6R)-2-amino-6-methyl-5,6,7,8-tetrahydropteridin-4(3H)-one, Dihydropteroate synthase, SULFATE ION | Authors: | Yun, M.-K, White, S.W. | Deposit date: | 2009-04-14 | Release date: | 2009-12-08 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural studies of pterin-based inhibitors of dihydropteroate synthase. J.Med.Chem., 53, 2010
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3H2A
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![BU of 3h2a by Molmil](/molmil-images/mine/3h2a) | |