4NJS
| Crystal structure of multidrug-resistant clinical isolate A02 HIV-1 protease in complex with non-peptidic inhibitor, GRL008 | Descriptor: | (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,3R)-4-{[(4-carbamoylphenyl)sulfonyl](2-methylpropyl)amino}-3-hydroxy-1-phenylbutan-2-yl]carbamate, Protease | Authors: | Yedidi, R.S, Garimella, H, Kaufman, J.D, Das, D, Wingfield, P.T, Ghosh, A.K, Mitsuya, H. | Deposit date: | 2013-11-11 | Release date: | 2014-04-02 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | A Conserved Hydrogen-Bonding Network of P2 bis-Tetrahydrofuran-Containing HIV-1 Protease Inhibitors (PIs) with a Protease Active-Site Amino Acid Backbone Aids in Their Activity against PI-Resistant HIV. Antimicrob.Agents Chemother., 58, 2014
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2X7L
| Implications of the HIV-1 Rev dimer structure at 3.2A resolution for multimeric binding to the Rev response element | Descriptor: | FAB HEAVY CHAIN, FAB LIGHT CHAIN, PROTEIN REV | Authors: | DiMattia, M.A, Watts, N.R, Stahl, S.J, Rader, C, Wingfield, P.T, Stuart, D.I, Steven, A.C, Grimes, J.M. | Deposit date: | 2010-03-01 | Release date: | 2010-03-23 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.17 Å) | Cite: | Implications of the HIV-1 Rev Dimer Structure at 3. 2 A Resolution for Multimeric Binding to the Rev Response Element. Proc.Natl.Acad.Sci.USA, 107, 2010
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6UI6
| HBV T=3 149C3A | Descriptor: | Core protein | Authors: | Wu, W, Watts, N.R, Cheng, N, Huang, R, Steven, A, Wingfield, P.T. | Deposit date: | 2019-09-30 | Release date: | 2019-11-06 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.53 Å) | Cite: | Expression of quasi-equivalence and capsid dimorphism in the Hepadnaviridae. Plos Comput.Biol., 16, 2020
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6UI7
| HBV T=4 149C3A | Descriptor: | Core protein | Authors: | Wu, W, Watts, N.R, Cheng, N, Huang, R, Steven, A, Wingfield, P.T. | Deposit date: | 2019-09-30 | Release date: | 2019-11-06 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.65 Å) | Cite: | Expression of quasi-equivalence and capsid dimorphism in the Hepadnaviridae. Plos Comput.Biol., 16, 2020
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2NEF
| HIV-1 NEF (REGULATORY FACTOR), NMR, 40 STRUCTURES | Descriptor: | NEGATIVE FACTOR (F-PROTEIN) | Authors: | Grzesiek, S, Bax, A, Clore, G.M, Gronenborn, A.M, Hu, J.S, Kaufman, J, Palmer, I, Stahl, S.J, Tjandra, N, Wingfield, P.T. | Deposit date: | 1997-02-12 | Release date: | 1997-07-07 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Refined solution structure and backbone dynamics of HIV-1 Nef. Protein Sci., 6, 1997
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4RVI
| Crystal structure of multidrug-resistant clinical isolate A02 HIV-1 protease in complex with non-peptidic inhibitor, GRL0519 | Descriptor: | (3R,3aS,3bR,6aS,7aS)-octahydrodifuro[2,3-b:3',2'-d]furan-3-yl [(1S,2R)-1-benzyl-2-hydroxy-3-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}propyl]carbamate, HIV-1 protease | Authors: | Yedidi, R.S, Garimella, H, Kaufman, J.D, Das, D, Wingfield, P.T, Ghosh, A.K, Mitsuya, H. | Deposit date: | 2014-11-26 | Release date: | 2016-05-04 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Enhanced antiviral activity by the P2-tris-tetrahydrofuran moiety of GRL-0519, a novel nonpeptidic HIV-1 protease inhibitor (PI), against multi-PI-resistant and highly darunavir-resistant strains of HIV-1 To be Published
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4RVX
| Crystal structure of multidrug-resistant clinical isolate A02 HIV-1 protease in complex with non-peptidic inhibitor, GRL079 | Descriptor: | (4S)-4-amino-N-[(2S,3S)-3-hydroxy-4-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}-1-phenylbutan-2-yl]-3,4-dihydro-2H-chromene-6-carboxamide, HIV-1 Protease | Authors: | Yedidi, R.S, Garimella, H, Kaufman, J.D, Das, D, Wingfield, P.T, Ghosh, A.K, Mitsuya, H. | Deposit date: | 2014-11-28 | Release date: | 2016-05-04 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.955 Å) | Cite: | Enhanced antiviral activity by the P2-tris-tetrahydrofuran moiety of GRL-0519, a novel nonpeptidic HIV-1 protease inhibitor (PI), against multi-PI-resistant and highly darunavir-resistant strains of HIV-1. To be Published
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2HGF
| HAIRPIN LOOP CONTAINING DOMAIN OF HEPATOCYTE GROWTH FACTOR, NMR, MINIMIZED AVERAGE STRUCTURE | Descriptor: | HEPATOCYTE GROWTH FACTOR | Authors: | Zhou, H, Mazzulla, M.J, Kaufman, J.D, Stahl, S.J, Wingfield, P.T, Rubin, J.S, Bottaro, D.P, Byrd, R.A. | Deposit date: | 1997-12-18 | Release date: | 1998-06-24 | Last modified: | 2022-03-09 | Method: | SOLUTION NMR | Cite: | The solution structure of the N-terminal domain of hepatocyte growth factor reveals a potential heparin-binding site. Structure, 6, 1998
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2JR0
| Solution structure of NusB from Aquifex Aeolicus | Descriptor: | N utilization substance protein B homolog | Authors: | Das, R, Loss, S, Li, J, Tarasov, S, Wingfield, P, Waugh, D.S, Byrd, R.A, Altieri, A.S. | Deposit date: | 2007-06-18 | Release date: | 2008-02-19 | Last modified: | 2024-05-08 | Method: | SOLUTION NMR | Cite: | Structural biophysics of the NusB:NusE antitermination complex. J.Mol.Biol., 376, 2008
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4HLA
| Crystal structure of wild type HIV-1 protease in complex with darunavir | Descriptor: | (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, Protease | Authors: | Yedidi, R.S, Garimella, H, Palmer, I, Das, D, Wingfield, P.T, Ghosh, A.K, Mitsuya, H. | Deposit date: | 2012-10-16 | Release date: | 2013-07-24 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | P2' benzene carboxylic acid moiety is associated with decrease in cellular uptake: evaluation of novel non-peptidic HIV-1 protease inhibitors containing P2 bis-tetrahydrofuran moiety. Antimicrob.Agents Chemother., 57, 2013
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4I8W
| Crystal structure of wild type HIV-1 protease in complex with non-peptidic inhibitor, GRL007 | Descriptor: | 4-{[(2R,3S)-3-({[(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yloxy]carbonyl}amino)-2-hydroxy-4-phenylbutyl](2-methylpropyl)sulfamoyl}benzoic acid, Protease | Authors: | Yedidi, R.S, Palmer, I, Das, D, Wingfield, P.T, Ghosh, A.K, Mitsuya, H. | Deposit date: | 2012-12-04 | Release date: | 2013-07-24 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.96 Å) | Cite: | P2' benzene carboxylic acid moiety is associated with decrease in cellular uptake: evaluation of novel non-peptidic HIV-1 protease inhibitors containing P2 bis-tetrahydrofuran moiety. Antimicrob.Agents Chemother., 57, 2013
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4I8Z
| Crystal structure of wild type HIV-1 protease in complex with non-peptidic inhibitor, GRL008 | Descriptor: | (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,3R)-4-{[(4-carbamoylphenyl)sulfonyl](2-methylpropyl)amino}-3-hydroxy-1-phenylbutan-2-yl]carbamate, Protease | Authors: | Yedidi, R.S, Palmer, I, Das, D, Wingfield, P.T, Ghosh, A.K, Mitsuya, H. | Deposit date: | 2012-12-04 | Release date: | 2013-07-24 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | P2' benzene carboxylic acid moiety is associated with decrease in cellular uptake: evaluation of novel non-peptidic HIV-1 protease inhibitors containing P2 bis-tetrahydrofuran moiety. Antimicrob.Agents Chemother., 57, 2013
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6CF2
| Crystal structure of HIV-1 Rev (residues 1-93)-RNA aptamer complex | Descriptor: | Anti-Rev Antibody, heavy chain, light chain, ... | Authors: | Eren, E, Dearborn, A.D, Wingfield, P.T. | Deposit date: | 2018-02-13 | Release date: | 2018-07-25 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structure of an RNA Aptamer that Can Inhibit HIV-1 by Blocking Rev-Cognate RNA (RRE) Binding and Rev-Rev Association. Structure, 26, 2018
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6BSY
| HIV-1 Rev assembly domain (residues 1-69) | Descriptor: | PHOSPHATE ION, Protein Rev | Authors: | Watts, N.R, Eren, E, Zhuang, X, Wang, Y.X, Steven, A.C, Wingfield, P.T. | Deposit date: | 2017-12-04 | Release date: | 2018-04-11 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | A new HIV-1 Rev structure optimizes interaction with target RNA (RRE) for nuclear export. J. Struct. Biol., 203, 2018
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5DHX
| HIV-1 Rev NTD dimers with variable crossing angles | Descriptor: | Anti-Rev Antibody Fab single-chain variable fragment, light chain,Anti-Rev Antibody Fab single-chain variable fragment, heavy chain, ... | Authors: | DiMattia, M.A, Watts, N.R, Wingfield, P.T, Grimes, J.M, Stuart, D.I, Steven, A.C. | Deposit date: | 2015-08-31 | Release date: | 2016-06-22 | Last modified: | 2017-08-30 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | The Structure of HIV-1 Rev Filaments Suggests a Bilateral Model for Rev-RRE Assembly. Structure, 24, 2016
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5DHZ
| HIV-1 Rev NTD dimers with variable crossing angles | Descriptor: | Anti-Rev Antibody Fab single-chain variable fragment, heavy chain, light chain, ... | Authors: | DiMattia, M.A, Watts, N.R, Wingfield, P.T, Grimes, J.M, Stuart, D.I, Steven, A.C. | Deposit date: | 2015-08-31 | Release date: | 2016-06-29 | Last modified: | 2017-08-30 | Method: | X-RAY DIFFRACTION (4.3 Å) | Cite: | The Structure of HIV-1 Rev Filaments Suggests a Bilateral Model for Rev-RRE Assembly. Structure, 24, 2016
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5DHV
| HIV-1 Rev NTD dimers with variable crossing angles | Descriptor: | Anti-Rev Antibody Fab single-chain variable fragment, heavy chain, light chain, ... | Authors: | DiMattia, M.A, Watts, N.R, Wingfield, P.T, Grimes, J.M, Stuart, D.I, Steven, A.C. | Deposit date: | 2015-08-31 | Release date: | 2016-06-22 | Last modified: | 2017-08-30 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The Structure of HIV-1 Rev Filaments Suggests a Bilateral Model for Rev-RRE Assembly. Structure, 24, 2016
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6CVK
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5DHY
| HIV-1 Rev NTD dimers with variable crossing angles | Descriptor: | Anti-Rev Antibody Fab single-chain variable fragment, heavy chain, light chain, ... | Authors: | DiMattia, M.A, Watts, N.R, Wingfield, P.T, Grimes, J.M, Stuart, D.I, Steven, A.C. | Deposit date: | 2015-08-31 | Release date: | 2016-06-22 | Last modified: | 2017-08-30 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | The Structure of HIV-1 Rev Filaments Suggests a Bilateral Model for Rev-RRE Assembly. Structure, 24, 2016
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4NJU
| Crystal structure of multidrug-resistant clinical isolate A02 HIV-1 protease in complex with tipranavir | Descriptor: | N-(3-{(1R)-1-[(6R)-4-HYDROXY-2-OXO-6-PHENETHYL-6-PROPYL-5,6-DIHYDRO-2H-PYRAN-3-YL]PROPYL}PHENYL)-5-(TRIFLUOROMETHYL)-2-PYRIDINESULFONAMIDE, Protease | Authors: | Yedidi, R.S, Garimella, H, Kaufman, J.D, Das, D, Wingfield, P.T, Mitsuya, H. | Deposit date: | 2013-11-11 | Release date: | 2014-04-02 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | A Conserved Hydrogen-Bonding Network of P2 bis-Tetrahydrofuran-Containing HIV-1 Protease Inhibitors (PIs) with a Protease Active-Site Amino Acid Backbone Aids in Their Activity against PI-Resistant HIV. Antimicrob.Agents Chemother., 58, 2014
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4NJT
| Crystal structure of multidrug-resistant clinical isolate A02 HIV-1 protease in complex with darunavir | Descriptor: | (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, Protease | Authors: | Yedidi, R.S, Garimella, H, Chang, S.B, Kaufman, J.D, Das, D, Wingfield, P.T, Ghosh, A.K, Mitsuya, H. | Deposit date: | 2013-11-11 | Release date: | 2014-04-02 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | A Conserved Hydrogen-Bonding Network of P2 bis-Tetrahydrofuran-Containing HIV-1 Protease Inhibitors (PIs) with a Protease Active-Site Amino Acid Backbone Aids in Their Activity against PI-Resistant HIV. Antimicrob.Agents Chemother., 58, 2014
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4NJV
| Crystal structure of multidrug-resistant clinical isolate A02 HIV-1 protease in complex with ritonavir | Descriptor: | Protease, RITONAVIR | Authors: | Yedidi, R.S, Garimella, H, Chang, S.B, Kaufman, J.D, Das, D, Wingfield, P.T, Mitsuya, H. | Deposit date: | 2013-11-11 | Release date: | 2014-04-02 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | A Conserved Hydrogen-Bonding Network of P2 bis-Tetrahydrofuran-Containing HIV-1 Protease Inhibitors (PIs) with a Protease Active-Site Amino Acid Backbone Aids in Their Activity against PI-Resistant HIV. Antimicrob.Agents Chemother., 58, 2014
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4RVJ
| Crystal structure of multidrug-resistant clinical isolate A02 HIV-1 protease in complex with amprenavir | Descriptor: | HIV-1 protease, {3-[(4-AMINO-BENZENESULFONYL)-ISOBUTYL-AMINO]-1-BENZYL-2-HYDROXY-PROPYL}-CARBAMIC ACID TETRAHYDRO-FURAN-3-YL ESTER | Authors: | Yedidi, R.S, Garimella, H, Kaufman, J.D, Das, D, Wingfield, P.T, Mitsuya, H. | Deposit date: | 2014-11-26 | Release date: | 2016-05-04 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Enhanced antiviral activity by the P2-tris-tetrahydrofuran moiety of GRL-0519, a novel nonpeptidic HIV-1 protease inhibitor (PI), against multi-PI-resistant and highly darunavir-resistant strains of HIV-1 To be Published
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6CWT
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6CWD
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