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PDB: 20 results

6IBL
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BU of 6ibl by Molmil
ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND AGONIST FORMOTEROL AND NANOBODY Nb80
Descriptor: Camelid antibody fragment Nb80, HEGA-10, SODIUM ION, ...
Authors:Warne, T, Edwards, P.C, Dore, A.S, Leslie, A.G.W, Tate, C.G.
Deposit date:2018-11-30
Release date:2019-01-09
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Molecular basis of beta-arrestin coupling to formoterol-bound beta1-adrenoceptor.
Nature, 583, 2020
4AMJ
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Turkey beta1 adrenergic receptor with stabilising mutations and bound biased agonist carvedilol
Descriptor: (2S)-1-(8H-CARBAZOL-4-YLOXY)-3-[2-(2-METHOXYPHENOXY)ETHYLAMINO]PROPAN-2-OL, BETA-1 ADRENERGIC RECEPTOR, HEGA-10, ...
Authors:Warne, T, Edwards, P.C, Leslie, A.G, Tate, C.G.
Deposit date:2012-03-12
Release date:2012-05-23
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structures of a Stabilized Beta1-Adrenoceptor Bound to the Biased Agonists Bucindolol and Carvedilol
Structure, 20, 2012
4AMI
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Turkey beta1 adrenergic receptor with stabilising mutations and bound biased agonist bucindolol
Descriptor: 2-[(2S)-3-[[1-(1H-indol-3-yl)-2-methyl-propan-2-yl]amino]-2-oxidanyl-propoxy]benzenecarbonitrile, BETA-1 ADRENERGIC RECEPTOR, HEGA-10
Authors:Warne, T, Edwards, P.C, Leslie, A.G, Tate, C.G.
Deposit date:2012-03-11
Release date:2012-05-23
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal Structures of a Stabilized Beta1-Adrenoceptor Bound to the Biased Agonists Bucindolol and Carvedilol
Structure, 20, 2012
6H7L
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BU of 6h7l by Molmil
ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND PARTIAL AGONIST DOBUTAMINE AND NANOBODY Nb6B9
Descriptor: Beta-1 adrenergic receptor, Camelid antibody fragment Nb6B9, DOBUTAMINE, ...
Authors:Warne, T, Edwards, P.C, Dore, A.S, Leslie, A.G.W, Tate, C.G.
Deposit date:2018-07-31
Release date:2018-10-17
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Molecular basis for high-affinity agonist binding in GPCRs.
Science, 364, 2019
6H7O
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ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND WEAK PARTIAL AGONIST CYANOPINDOLOL AND NANOBODY Nb6B9
Descriptor: 4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile, Beta-1 adrenergic receptor, Camelid antibody fragment Nb6B9, ...
Authors:Warne, T, Edwards, P.C, Dore, A.S, Leslie, A.G.W, Tate, C.G.
Deposit date:2018-07-31
Release date:2018-10-17
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Molecular basis for high-affinity agonist binding in GPCRs.
Science, 364, 2019
6H7N
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ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND PARTIAL AGONIST XAMOTEROL AND NANOBODY Nb6B9
Descriptor: Beta-1 adrenergic receptor, Camelid antibody fragment Nb6B9, HEGA-10, ...
Authors:Warne, T, Edwards, P.C, Dore, A.S, Leslie, A.G.W, Tate, C.G.
Deposit date:2018-07-31
Release date:2018-10-17
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Molecular basis for high affinity agonist binding in GPCRs
Biorxiv, 2018
6H7M
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BU of 6h7m by Molmil
ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND PARTIAL AGONIST SALBUTAMOL AND NANOBODY Nb6B9
Descriptor: Beta-1 adrenergic receptor, Camelid antibody fragment Nb6B9, HEGA-10, ...
Authors:Warne, T, Edwards, P.C, Dore, A.S, Leslie, A.G.W, Tate, C.G.
Deposit date:2018-07-31
Release date:2018-10-17
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Molecular basis for high-affinity agonist binding in GPCRs.
Science, 364, 2019
6H7J
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BU of 6h7j by Molmil
ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND AGONIST ISOPRENALINE AND NANOBODY Nb80
Descriptor: Beta-1 adrenergic receptor, Camelid antibody fragment Nb80, HEGA-10, ...
Authors:Warne, T, Edwards, P.C, Dore, A.S, Leslie, A.G.W, Tate, C.G.
Deposit date:2018-07-31
Release date:2018-10-17
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Molecular basis for high-affinity agonist binding in GPCRs.
Science, 364, 2019
3ZPQ
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BU of 3zpq by Molmil
Thermostabilised turkey beta1 adrenergic receptor with 4-(piperazin-1- yl)-1H-indole bound (compound 19)
Descriptor: 4-(PIPERAZIN-1-YL)-1H-INDOLE, BETA-1 ADRENERGIC RECEPTOR, CHOLESTEROL HEMISUCCINATE, ...
Authors:Christopher, J.A, Congreve, M, Dore, A.S, Marshall, F.H, Myszka, D.G, Brown, J, Koglin, M, Tehan, B, Errey, J.C, Tate, C.G, Warne, T.
Deposit date:2013-03-01
Release date:2013-04-03
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Biophysical Fragment Screening of the Beta1-Adrenergic Receptor: Identification of High Affinity Aryl Piperazine Leads Using Structure-Based Drug Design.
J.Med.Chem., 56, 2013
3ZPR
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Thermostabilised turkey beta1 adrenergic receptor with 4-methyl-2-(piperazin-1-yl) quinoline bound
Descriptor: 4-METHYL-2-(PIPERAZIN-1-YL) QUINOLINE, BETA-1 ADRENERGIC RECEPTOR, CHOLESTEROL HEMISUCCINATE, ...
Authors:Christopher, J.A, Congreve, M, Dore, A.S, Marshall, F.H, Myszka, D.G, Brown, J, Koglin, M, Tehan, B, Errey, J.C, Tate, C.G, Warne, T.
Deposit date:2013-03-01
Release date:2013-04-03
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Biophysical Fragment Screening of the Beta1-Adrenergic Receptor: Identification of High Affinity Aryl Piperazine Leads Using Structure-Based Drug Design.
J.Med.Chem., 56, 2013
5G53
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BU of 5g53 by Molmil
Structure of the adenosine A2A receptor bound to an engineered G protein
Descriptor: ADENOSINE RECEPTOR A2A, ENGINEERED DOMAIN OF HUMAN G ALPHA S LONG ISOFORM, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Carpenter, B, Nehme, R, Warne, T, Leslie, A.G.W, Tate, C.G.
Deposit date:2016-05-19
Release date:2016-08-03
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structure of the Adenosine A2A Receptor Bound to an Engineered G Protein
Nature, 536, 2016
5A8E
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BU of 5a8e by Molmil
thermostabilised beta1-adrenoceptor with rationally designed inverse agonist 7-methylcyanopindolol bound
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC ACID, 4-[(2S)-3-(tert-butylamino)-2-hydroxypropoxy]-7-methyl-1H-indole-2-carbonitrile, ...
Authors:Sato, T, Baker, J.G, Warne, T, Brown, G.A, Congreve, M, Leslie, A.G.W, Tate, C.G.
Deposit date:2015-07-15
Release date:2015-09-30
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Pharmacological Analysis and Structure Determination of 7-Methylcyanopindolol-Bound Beta1-Adrenergic Receptor.
Mol.Pharmacol., 88, 2015
4BVN
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BU of 4bvn by Molmil
Ultra-thermostable beta1-adrenoceptor with cyanopindolol bound
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC ACID, 4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile, ...
Authors:Miller, J, Nehme, R, Warne, T, Edwards, P.C, Leslie, A.G.W, Schertler, G, Tate, C.G.
Deposit date:2013-06-26
Release date:2014-04-02
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The 2.1 A Resolution Structure of Cyanopindolol-Bound Beta1- Adrenoceptor Identifies an Intramembrane Na+ Ion that Stabilises the Ligand-Free Receptor.
Plos One, 9, 2014
2YCW
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BU of 2ycw by Molmil
TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND ANTAGONIST CARAZOLOL
Descriptor: (2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol, BETA-1 ADRENERGIC RECEPTOR, HEGA-10, ...
Authors:Moukhametzianov, R, Warne, T, Edwards, P.C, Serrano-Vega, M.J, Leslie, A.G.W, Tate, C.G, Schertler, G.F.X.
Deposit date:2011-03-17
Release date:2011-06-01
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3 Å)
Cite:Two Distinct Conformations of Helix 6 Observed in Antagonist-Bound Structures of a Beta-1- Adrenergic Receptor.
Proc.Natl.Acad.Sci.USA, 108, 2011
2YCX
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BU of 2ycx by Molmil
TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND ANTAGONIST CYANOPINDOLOL
Descriptor: 4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile, BETA-1 ADRENERGIC RECEPTOR, octyl 1-thio-beta-D-glucopyranoside
Authors:Moukhametzianov, R, Warne, T, Edwards, P.C, Serrano-Vega, M.J, Leslie, A.G.W, Tate, C.G, Schertler, G.F.X.
Deposit date:2011-03-17
Release date:2011-06-01
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Two Distinct Conformations of Helix 6 Observed in Antagonist-Bound Structures of a Beta-1- Adrenergic Receptor.
Proc.Natl.Acad.Sci.USA, 108, 2011
2YCY
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BU of 2ycy by Molmil
TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND ANTAGONIST CYANOPINDOLOL
Descriptor: 4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile, BETA-1 ADRENERGIC RECEPTOR, SODIUM ION, ...
Authors:Moukhametzianov, R, Warne, T, Edwards, P.C, Serrano-Vega, M.J, Leslie, A.G.W, Tate, C.G, Schertler, G.F.X.
Deposit date:2011-03-17
Release date:2011-06-08
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Two Distinct Conformations of Helix 6 Observed in Antagonist-Bound Structures of a {Beta}1- Adrenergic Receptor.
Proc.Natl.Acad.Sci.USA, 108, 2011
2YCZ
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TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND ANTAGONIST IODOCYANOPINDOLOL
Descriptor: 4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3-iodo-1H-indole-2-carbonitrile, BETA-1 ADRENERGIC RECEPTOR, octyl 1-thio-beta-D-glucopyranoside
Authors:Moukhametzianov, R, Warne, T, Edwards, P.C, Serrano-Vega, M.J, Leslie, A.G.W, Tate, C.G, Schertler, G.F.X.
Deposit date:2011-03-17
Release date:2011-06-01
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.65 Å)
Cite:Two Distinct Conformations of Helix 6 Observed in Antagonist-Bound Structures of a {Beta}1- Adrenergic Receptor.
Proc.Natl.Acad.Sci.USA, 108, 2011
2YDO
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BU of 2ydo by Molmil
Thermostabilised HUMAN A2a Receptor with adenosine bound
Descriptor: ADENOSINE, ADENOSINE RECEPTOR A2A, octyl 1-thio-beta-D-glucopyranoside
Authors:Lebon, G, Warne, T, Edwards, P.C, Bennett, K, Langmead, C.J, Leslie, A.G.W, Tate, C.G.
Deposit date:2011-03-23
Release date:2011-05-18
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3 Å)
Cite:Agonist-Bound Adenosine A(2A) Receptor Structures Reveal Common Features of Gpcr Activation.
Nature, 474, 2011
2YDV
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BU of 2ydv by Molmil
Thermostabilised HUMAN A2a Receptor with NECA bound
Descriptor: ADENOSINE RECEPTOR A2A, N-ETHYL-5'-CARBOXAMIDO ADENOSINE, octyl 1-thio-beta-D-glucopyranoside
Authors:Lebon, G, Warne, T, Edwards, P.C, Bennett, K, Langmead, C.J, Leslie, A.G.W, Tate, C.G.
Deposit date:2011-03-24
Release date:2011-05-18
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Agonist-Bound Adenosine A(2A) Receptor Structures Reveal Common Features of Gpcr Activation.
Nature, 474, 2011
8A9L
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BU of 8a9l by Molmil
Cryo-EM structure of alpha-synuclein filaments from Parkinson's disease and dementia with Lewy bodies
Descriptor: Alpha-synuclein, Unknown fragment
Authors:Yang, Y, Shi, Y, Schweighauser, M, Zhang, X.J, Kotecha, A, Murzin, A.G, Garringer, H.J, Cullinane, P, Saito, Y, Foroud, T, Warner, T.T, Hasegawa, K, Vidal, R, Murayama, S, Revesz, T, Ghetti, B, Hasegawa, M, Lashley, T, Scheres, H.W.S, Goedert, M.
Deposit date:2022-06-28
Release date:2022-08-31
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (2.2 Å)
Cite:Structures of alpha-synuclein filaments from human brains with Lewy pathology.
Nature, 610, 2022

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