5DTI
 
 | | Crystal structure of mouse acetylcholinesterase | | Descriptor: | Acetylcholinesterase | | Authors: | Tran, T.H, Tong, L. | | Deposit date: | 2015-09-18 | | Release date: | 2015-10-21 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.003 Å) | | Cite: | Discovery of New Classes of Compounds that Reactivate Acetylcholinesterase Inhibited by Organophosphates.
Chembiochem, 16, 2015
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3C3E
 | | Crystal structure of 2-phospho-(S)-lactate transferase from Methanosarcina mazei in complex with Fo and GDP. Northeast Structural Genomics Consortium target MaR46 | | Descriptor: | 1-deoxy-1-(8-hydroxy-2,4-dioxo-3,4-dihydropyrimido[4,5-b]quinolin-10(2H)-yl)-D-ribitol, 2-phospho-L-lactate transferase, GUANOSINE-5'-DIPHOSPHATE | | Authors: | Forouhar, F, Abashidze, M, Xu, H, Grochowski, L.L, Seetharaman, J, Hussain, M, Kuzin, A.P, Chen, Y, Zhou, W, Xiao, R, Acton, T.B, Montelione, G.T, Galinier, A, White, R.H, Tong, L, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2008-01-28 | | Release date: | 2008-02-19 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Molecular insights into the biosynthesis of the f420 coenzyme.
J.Biol.Chem., 283, 2008
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1JQ7
 | | HCMV protease dimer-interface mutant, S225Y complexed to Inhibitor BILC 408 | | Descriptor: | ASSEMBLIN, N-(6-aminohexanoyl)-3-methyl-L-valyl-3-methyl-L-valyl-N~1~-[(2S,3S)-3-hydroxy-4-oxo-4-{[(1R)-1-phenylpropyl]amino}butan-2-yl]-N~4~,N~4~-dimethyl-L-aspartamide | | Authors: | Batra, R, Khayat, R, Tong, L. | | Deposit date: | 2001-08-03 | | Release date: | 2001-09-12 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Molecular mechanism for dimerization to regulate the catalytic activity of human cytomegalovirus protease.
Nat.Struct.Biol., 8, 2001
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1H2H
 | | Crystal structure of TM1643 | | Descriptor: | HYPOTHETICAL PROTEIN TM1643, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | Authors: | Yang, Z, Savchenko, A, Edwards, A, Arrowsmith, C, Tong, L, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2002-08-08 | | Release date: | 2002-08-15 | | Last modified: | 2019-08-21 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Aspartate dehydrogenase, a novel enzyme identified from structural and functional studies of TM1643.
J. Biol. Chem., 278, 2003
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7UG9
 | | Crystal structure of RNase AM PHP domain | | Descriptor: | 5'-3' exoribonuclease, MANGANESE (II) ION, SULFATE ION | | Authors: | Doamekpor, S.K, Tong, L. | | Deposit date: | 2022-03-24 | | Release date: | 2022-08-31 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.69 Å) | | Cite: | Identification of a novel deFADding activity in human, yeast and bacterial 5' to 3' exoribonucleases.
Nucleic Acids Res., 50, 2022
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3BEY
 | | Crystal structure of the protein O27018 from Methanobacterium thermoautotrophicum. Northeast Structural Genomics Consortium target TT217 | | Descriptor: | Conserved protein O27018 | | Authors: | Kuzin, A.P, Gu, J, Xu, X, Neely, H, Forouhar, F, Owens, L, Mao, L, Xiao, R, Liu, J, Baran, M.C, Acton, T.B, Rost, B, Montelione, G.T, Tong, L, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2007-11-20 | | Release date: | 2007-12-18 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal structure of the protein O27018 from Methanobacterium thermoautotrophicum.
To be Published
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3BID
 | | Crystal structure of the NMB1088 protein from Neisseria meningitidis. Northeast Structural Genomics Consortium target MR91 | | Descriptor: | UPF0339 protein NMB1088 | | Authors: | Forouhar, F, Neely, H, Seetharaman, J, Mao, L, Fang, Y, Xiao, R, Owen, L.A, Maglaqui, M, Cunningham, K, Baran, M.C, Acton, T.B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2007-11-30 | | Release date: | 2007-12-18 | | Last modified: | 2020-01-22 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Crystal structure of the NMB1088 protein from Neisseria meningitidis.
To be Published
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3BB6
 | | Crystal structure of the P64488 protein from E.coli (strain K12). Northeast Structural Genomics Consortium target ER596 | | Descriptor: | Uncharacterized protein yeaR, ZINC ION | | Authors: | Kuzin, A.P, Su, M, Seetharaman, J, Wang, D, Janjua, H, Owens, L, Ma, L.-C, Xiao, R, Liu, J, Baran, M.C, Acton, T.B, Rost, B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2007-11-09 | | Release date: | 2007-11-20 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | X-Ray structure of the P64488 from E.coli (strain K12).
To be Published
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3C0D
 | | Crystal structure of the putative nitrite reductase NADPH (small subunit) oxidoreductase protein Q87HB1. Northeast Structural Genomics Consortium target VpR162 | | Descriptor: | Putative nitrite reductase NADPH (Small subunit) oxidoreductase protein | | Authors: | Kuzin, A.P, Abashidze, M, Seetharaman, J, Vorobiev, S.M, Wang, D, Fang, Y, Owens, L, Ma, L.-C, Xiao, R, Liu, J, Baran, M.C, Acton, T.B, Rost, B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2008-01-19 | | Release date: | 2008-03-04 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal structure of the putative nitrite reductase NADPH (small subunit) oxidoreductase protein Q87HB1.
To be Published
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6APL
 | | Crystal Structure of human ST6GALNAC2 in complex with CMP | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2, CYTIDINE-5'-MONOPHOSPHATE | | Authors: | Forouhar, F, Moremen, K.W, Northeast Structural Genomics Consortium (NESG), Tong, L. | | Deposit date: | 2017-08-17 | | Release date: | 2017-12-20 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Expression system for structural and functional studies of human glycosylation enzymes.
Nat. Chem. Biol., 14, 2018
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3BHP
 | | Crystal structure of UPF0291 protein ynzC from Bacillus subtilis at resolution 2.0 A. Northeast Structural Genomics Consortium target SR384 | | Descriptor: | UPF0291 protein ynzC | | Authors: | Kuzin, A.P, Su, M, Seetharaman, J, Janjua, H, Cunningham, K, Maglaqui, M, Owens, L.A, Zhao, L, Xiao, R, Baran, M.C, Acton, T.B, Rost, B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2007-11-28 | | Release date: | 2007-12-11 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.01 Å) | | Cite: | Crystal structure of the UPF0291 protein ynzC from Bacillus subtilis at the resolution 2.0 A.
To be Published
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3C5M
 | | Crystal structure of oligogalacturonate lyase (VPA0088) from Vibrio parahaemolyticus. Northeast Structural Genomics Consortium Target VpR199 | | Descriptor: | MANGANESE (II) ION, Oligogalacturonate lyase | | Authors: | Forouhar, F, Abashidze, M, Seetharaman, J, Janjua, H, Mao, L, Xiao, R, Owens, L.A, Wang, D, Baran, M.C, Acton, T.B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2008-01-31 | | Release date: | 2008-02-26 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal structure of oligogalacturonate lyase (VPA0088) from Vibrio parahaemolyticus.
To be Published
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3C4N
 | | Crystal structure of DR_0571 protein from Deinococcus radiodurans in complex with ADP. Northeast Structural Genomics Consortium Target DrR125 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Uncharacterized protein DR_0571 | | Authors: | Forouhar, F, Chen, Y, Seetharaman, J, Mao, L, Xiao, R, Cunningham, K, Owen, L.A, Maglaqui, M, Baran, M.C, Acton, T.B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2008-01-30 | | Release date: | 2008-02-26 | | Last modified: | 2017-10-25 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal structure of DR_0571 protein from Deinococcus radiodurans in complex with ADP.
To be Published
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3CFU
 | | Crystal structure of the yjhA protein from Bacillus subtilis. Northeast Structural Genomics Consortium target SR562 | | Descriptor: | Uncharacterized lipoprotein yjhA | | Authors: | Vorobiev, S.M, Chen, Y, Kuzin, A.P, Seetharaman, J, Forouhar, F, Zhao, L, Mao, L, Maglaqui, M, Xiao, R, Liu, J, Swapna, G, Huang, J.Y, Acton, T.B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2008-03-04 | | Release date: | 2008-03-18 | | Last modified: | 2017-10-25 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal structure of the yjhA protein from Bacillus subtilis.
To be Published
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2OKA
 | | Crystal structure of Q9HYQ7_PSEAE from Pseudomonas aeruginosa. Northeast Structural Genomics Consortium target PaR82 | | Descriptor: | Hypothetical protein | | Authors: | Benach, J, Neely, H, Seetharaman, J, Chen, X.C, Fang, Y, Cunningham, K, Owens, L, Ma, L.C, Xiao, R, Liu, J, Baran, M.C, Acton, T.B, Rost, B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2007-01-16 | | Release date: | 2007-01-23 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal structure of Q9HYQ7_PSEAE from Pseudomonas aeruginosa
To be Published
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2P0G
 | | Crystal structure of Selenoprotein W-related protein from Vibrio cholerae. Northeast Structural Genomics target VcR75 | | Descriptor: | Selenoprotein W-related protein | | Authors: | Benach, J, Neely, H, Seetharaman, J, Ho, C.K, Janjua, H, Cunningham, K, Ma, L, Xiao, R, Liu, J, Baran, M.C, Acton, T.B, Rost, B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2007-02-28 | | Release date: | 2007-03-20 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal structure of Selenoprotein W-related protein from Vibrio cholerae.
To be Published
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1BI8
 | | MECHANISM OF G1 CYCLIN DEPENDENT KINASE INHIBITION FROM THE STRUCTURES CDK6-P19INK4D INHIBITOR COMPLEX | | Descriptor: | CYCLIN-DEPENDENT KINASE 6, CYCLIN-DEPENDENT KINASE INHIBITOR | | Authors: | Russo, A.A, Tong, L, Lee, J.O, Jeffrey, P.D, Pavletich, N.P. | | Deposit date: | 1998-06-22 | | Release date: | 1999-01-13 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a.
Nature, 395, 1998
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1BI7
 | | MECHANISM OF G1 CYCLIN DEPENDENT KINASE INHIBITION FROM THE STRUCTURE OF THE CDK6-P16INK4A TUMOR SUPPRESSOR COMPLEX | | Descriptor: | CYCLIN-DEPENDENT KINASE 6, MULTIPLE TUMOR SUPPRESSOR | | Authors: | Russo, A.A, Tong, L, Lee, J.O, Jeffrey, P.D, Pavletich, N.P. | | Deposit date: | 1998-06-22 | | Release date: | 1999-01-13 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a.
Nature, 395, 1998
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6APJ
 | | Crystal Structure of human ST6GALNAC2 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | | Authors: | Forouhar, F, Moremen, K.W, Northeast Structural Genomics Consortium (NESG), Tong, L. | | Deposit date: | 2017-08-17 | | Release date: | 2017-12-20 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Expression system for structural and functional studies of human glycosylation enzymes.
Nat. Chem. Biol., 14, 2018
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3TJU
 | | Crystal structure of human granzyme H with an inhibitor | | Descriptor: | Ac-PTSY-CMK inhibitor, Granzyme H, SULFATE ION | | Authors: | Wang, L, Zhang, K, Wu, L, Tong, L, Sun, F, Fan, Z. | | Deposit date: | 2011-08-25 | | Release date: | 2011-12-28 | | Last modified: | 2023-12-06 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structural insights into the substrate specificity of human granzyme H: the functional roles of a novel RKR motif
J.Immunol., 188, 2012
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6DDK
 | | Crystal structure of the double mutant (D52N/R367Q) of the full-length NT5C2 in the basal state | | Descriptor: | Cytosolic purine 5'-nucleotidase, PHOSPHATE ION | | Authors: | Forouhar, F, Dieck, C.L, Tzoneva, G, Carpenter, Z, Ambesi-Impiombato, A, Sanchez-Martin, M, Kirschner-Schwabe, R, Lew, S, Seetharaman, J, Ferrando, A.A, Tong, L. | | Deposit date: | 2018-05-10 | | Release date: | 2018-07-04 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia.
Cancer Cell, 34, 2018
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6DDQ
 | | Crystal structure of the double mutant (R39Q/D52N) of the full-length NT5C2 in the basal state | | Descriptor: | 1,2-ETHANEDIOL, Cytosolic purine 5'-nucleotidase, PHOSPHATE ION | | Authors: | Forouhar, F, Dieck, C.L, Tzoneva, G, Carpenter, Z, Ambesi-Impiombato, A, Sanchez-Martin, M, Kirschner-Schwabe, R, Lew, S, Seetharaman, J, Ferrando, A.A, Tong, L. | | Deposit date: | 2018-05-10 | | Release date: | 2018-07-04 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.31 Å) | | Cite: | Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia.
Cancer Cell, 34, 2018
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1G3N
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6DDO
 | | Crystal structure of the single mutant (D52N) of the full-length NT5C2 in the basal state | | Descriptor: | Cytosolic purine 5'-nucleotidase, PHOSPHATE ION | | Authors: | Forouhar, F, Dieck, C.L, Tzoneva, G, Carpenter, Z, Ambesi-Impiombato, A, Sanchez-Martin, M, Kirschner-Schwabe, R, Lew, S, Seetharaman, J, Ferrando, A.A, Tong, L. | | Deposit date: | 2018-05-10 | | Release date: | 2018-07-04 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.48 Å) | | Cite: | Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia.
Cancer Cell, 34, 2018
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6E35
 | | Crystal structure of human indoleamime 2,3-dioxygenase (IDO1) in complex with L-Trp and cyanide, Northeast Structural Genomics Target HR6160 | | Descriptor: | 2-(1H-indol-3-yl)ethanol, CYANIDE ION, Indoleamine 2,3-dioxygenase 1, ... | | Authors: | Forouhar, F, Lewis-Ballester, A, Lew, S, Karkashon, S, Seetharaman, J, Lu, C, Hussain, M, Yeh, S.-R, Tong, L, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2018-07-13 | | Release date: | 2018-07-25 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.411 Å) | | Cite: | Crystal structure of human indoleamime 2,3-dioxygenase (IDO1) in complex with L-Trp and cyanide, Northeast Structural Genomics Target HR6160
To Be Published
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