8TLM
| Structure of a class A GPCR/Fab complex | Descriptor: | C-C chemokine receptor type 8, Green fluorescent protein fusion, Fab heavy chain, ... | Authors: | Sun, D, Johnson, M, Masureel, M. | Deposit date: | 2023-07-27 | Release date: | 2023-12-20 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural basis of antibody inhibition and chemokine activation of the human CC chemokine receptor 8. Nat Commun, 14, 2023
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8U1U
| Structure of a class A GPCR/agonist complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, C-C motif chemokine 1,C-C chemokine receptor type 8,EGFP fusion protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Sun, D, Johnson, M, Masureel, M. | Deposit date: | 2023-09-02 | Release date: | 2023-12-20 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis of antibody inhibition and chemokine activation of the human CC chemokine receptor 8. Nat Commun, 14, 2023
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7N9C
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7N9E
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7N9B
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6Q0X
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8U31
| Crystal structure of PD-1 in complex with a Fab | Descriptor: | Fab heavy chain, Fab light chain, GLYCEROL, ... | Authors: | Sun, D, Masureel, M. | Deposit date: | 2023-09-07 | Release date: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2.73 Å) | Cite: | Structure- and machine learning-guided engineering demonstrate that a non-canonical disulfide in an anti-PD-1 rabbit antibody does not impede antibody developability. Mabs, 16, 2024
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8U32
| Crystal structure of PD-1 in complex with a Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab heavy chain, Fab light chain, ... | Authors: | Sun, D, Masureel, M. | Deposit date: | 2023-09-07 | Release date: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2.51 Å) | Cite: | Structure- and machine learning-guided engineering demonstrate that a non-canonical disulfide in an anti-PD-1 rabbit antibody does not impede antibody developability. Mabs, 16, 2024
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7N9A
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1MG2
| MUTATION OF ALPHA PHE55 OF METHYLAMINE DEHYDROGENASE ALTERS THE REORGANIZATION ENERGY AND ELECTRONIC COUPLING FOR ITS ELECTRON TRANSFER REACTION WITH AMICYANIN | Descriptor: | Amicyanin, COPPER (II) ION, CYTOCHROME C-L, ... | Authors: | Sun, D, Chen, Z.W, Mathews, F.S, Davidson, V.L. | Deposit date: | 2002-08-14 | Release date: | 2002-12-11 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | MUTATION OF AlPHA PHE55 OF METHYLAMINE DEHYDROGENASE ALTERS THE REORGANIZATION ENERGY AND ELECTRONIC COUPLING FOR ITS ELECTRON TRANSFER REACTION WITH AMICYANIN Biochemistry, 41, 2002
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1MG3
| MUTATION OF ALPHA PHE55 OF METHYLAMINE DEHYDROGENASE ALTERS THE REORGANIZATION ENERGY AND ELECTRONIC COUPLING FOR ITS ELECTRON TRANSFER REACTION WITH AMICYANIN | Descriptor: | Amicyanin, COPPER (II) ION, CYTOCHROME C-L, ... | Authors: | Sun, D, Chen, Z.W, Mathews, F.S, Davidson, V.L. | Deposit date: | 2002-08-14 | Release date: | 2002-12-11 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | MUTATION OF ALPHA PHE55 OF METHYLAMINE DEHYDROGENASE ALTERS THE REORGANIZATION ENERGY AND ELECTRONIC COUPLING FOR ITS ELECTRON TRANSFER REACTION WITH AMICYANIN Biochemistry, 41, 2002
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8W0R
| Human EBP complexed with compound 1 | Descriptor: | 1-methyl-1'-[(oxan-4-yl)methyl]-5-(trifluoromethyl)spiro[indole-2,4'-piperidin]-3(1H)-one, 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase | Authors: | Sun, D, Masureel, M. | Deposit date: | 2024-02-14 | Release date: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Discovery and Optimization of Selective Brain-Penetrant EBP Inhibitors that Enhance Oligodendrocyte Formation. J.Med.Chem., 67, 2024
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8W0S
| Human EBP complexed with compound 3a | Descriptor: | 1-methyl-8-[(oxan-4-yl)methyl]-3-[4-(trifluoromethyl)phenyl]-1,3,8-triazaspiro[4.5]decane-2,4-dione, 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase | Authors: | Sun, D, Masureel, M. | Deposit date: | 2024-02-14 | Release date: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Discovery and Optimization of Selective Brain-Penetrant EBP Inhibitors that Enhance Oligodendrocyte Formation. J.Med.Chem., 67, 2024
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3K8T
| Structure of eukaryotic rnr large subunit R1 complexed with designed adp analog compound | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, 2'-deoxy-2'-(2-hydroxyethyl)adenosine 5'-(trihydrogen diphosphate), GLYCEROL, ... | Authors: | Sun, D, Xu, H, Dealwis, C, Lee, R.E. | Deposit date: | 2009-10-14 | Release date: | 2010-03-02 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure-Based Design, Synthesis, and Evaluation of 2'-(2-Hydroxyethyl)-2'-deoxyadenosine and the 5'-Diphosphate Derivative as Ribonucleotide Reductase Inhibitors Chemmedchem, 4, 2009
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4LSE
| Ion selectivity of OmpF porin soaked in 0.2M NaBr | Descriptor: | (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, BROMIDE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Balasundaresan, D, Blachowicz, L, Roux, B. | Deposit date: | 2013-07-22 | Release date: | 2013-10-23 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | A structural study of ion permeation in OmpF porin from anomalous X-ray diffraction and molecular dynamics simulations. J.Am.Chem.Soc., 135, 2013
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4LSH
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1XGF
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1S0H
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3HW9
| Cation selective pathway of OmpF porin revealed by anomalous x-ray diffraction | Descriptor: | CHLORIDE ION, HEXAETHYLENE GLYCOL, Outer membrane protein F, ... | Authors: | Balasundaresan, D, Raychaudhury, S, Blachowicz, L, Roux, B. | Deposit date: | 2009-06-17 | Release date: | 2009-12-08 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.61 Å) | Cite: | Cation-selective pathway of OmpF porin revealed by anomalous X-ray diffraction. J.Mol.Biol., 396, 2010
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3HWB
| Cation selective pathway of OmpF porin revealed by anomalous diffraction | Descriptor: | HEXAETHYLENE GLYCOL, Outer membrane protein F, RUBIDIUM ION | Authors: | Balasundaresan, D, Raychaudhury, S, Blachowicz, L, Roux, B. | Deposit date: | 2009-06-17 | Release date: | 2009-12-08 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Cation-selective pathway of OmpF porin revealed by anomalous X-ray diffraction. J.Mol.Biol., 396, 2010
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4LSF
| Ion selectivity of OmpF soaked in 0.1M KBr | Descriptor: | BROMIDE ION, GLYCEROL, Outer membrane protein F | Authors: | Balasundaresan, D, Blachowicz, L, Roux, B. | Deposit date: | 2013-07-22 | Release date: | 2013-10-23 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | A structural study of ion permeation in OmpF porin from anomalous X-ray diffraction and molecular dynamics simulations. J.Am.Chem.Soc., 135, 2013
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4LSI
| Ion selectivity of OmpF porin soaked in 0.3M KBr | Descriptor: | (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, BROMIDE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Balasundaresan, D, Blachowicz, L, Roux, B. | Deposit date: | 2013-07-22 | Release date: | 2013-10-23 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.089 Å) | Cite: | A structural study of ion permeation in OmpF porin from anomalous X-ray diffraction and molecular dynamics simulations. J.Am.Chem.Soc., 135, 2013
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1QAI
| CRYSTAL STRUCTURES OF THE N-TERMINAL FRAGMENT FROM MOLONEY MURINE LEUKEMIA VIRUS REVERSE TRANSCRIPTASE COMPLEXED WITH NUCLEIC ACID: FUNCTIONAL IMPLICATIONS FOR TEMPLATE-PRIMER BINDING TO THE FINGERS DOMAIN | Descriptor: | DNA (5'-D(*CP*AP*TP*GP*CP*AP*TP*G)-3'), MERCURY (II) ION, REVERSE TRANSCRIPTASE | Authors: | Najmudin, S, Cote, M, Sun, D, Yohannan, S, Montano, S.P, Gu, J, Georgiadis, M.M. | Deposit date: | 1999-03-12 | Release date: | 2000-03-20 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structures of an N-terminal fragment from Moloney murine leukemia virus reverse transcriptase complexed with nucleic acid: functional implications for template-primer binding to the fingers domain. J.Mol.Biol., 296, 2000
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1ZYH
| Structure of a Supercoiling Responsive DNA site | Descriptor: | 5'-D(*CP*AP*AP*CP*CP*AP*GP*GP*GP*TP*TP*G)-3', 5'-D(*CP*AP*AP*CP*CP*CP*TP*GP*GP*TP*TP*G)-3' | Authors: | Bae, S.H, Yun, S.H, Sun, D, Lim, H.M, Choi, B.S. | Deposit date: | 2005-06-10 | Release date: | 2006-05-23 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Structural and dynamic basis of a supercoiling-responsive DNA element Nucleic Acids Res., 34, 2006
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1ZYG
| Structure of a Supercoiling Responsive DNA Site | Descriptor: | 5'-D(*CP*AP*AP*CP*CP*CP*GP*GP*GP*TP*TP*G)-3' | Authors: | Bae, S.H, Yun, S.H, Sun, D, Lim, H.M, Choi, B.S. | Deposit date: | 2005-06-10 | Release date: | 2006-05-23 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Structural and dynamic basis of a supercoiling-responsive DNA element Nucleic Acids Res., 34, 2006
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