6YMU
 
 | | Imidazole Glycerol Phosphate Synthase | | Descriptor: | Imidazole glycerol phosphate synthase subunit HisF, Imidazole glycerol phosphate synthase subunit HisH | | Authors: | Sterner, R, Rajendran, C, Andrea, K. | | Deposit date: | 2020-04-09 | | Release date: | 2020-07-22 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.11 Å) | | Cite: | Significance of the Protein Interface Configuration for Allostery in Imidazole Glycerol Phosphate Synthase.
Biochemistry, 59, 2020
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4FX7
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4J35
 | | Molecular Engineering of Organophosphate Hydrolysis Activity from a Weak Promiscuous Lactonase Template | | Descriptor: | COBALT (II) ION, Phosphotriesterase, putative | | Authors: | Sterner, R, Raushel, F, Meier, M, Rajendran, C, Malisi, C, Fox, N, Schlee, S, Barondeau, D, Cker, B.H. | | Deposit date: | 2013-02-05 | | Release date: | 2013-07-24 | | Last modified: | 2013-09-04 | | Method: | X-RAY DIFFRACTION (1.783 Å) | | Cite: | Molecular engineering of organophosphate hydrolysis activity from a weak promiscuous lactonase template.
J.Am.Chem.Soc., 135, 2013
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4J9J
 | | Structure of designed HisF | | Descriptor: | Imidazole glycerol phosphate synthase subunit HisF | | Authors: | Sterner, R, Rajendran, C, Sperl, J. | | Deposit date: | 2013-02-16 | | Release date: | 2013-07-17 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Establishing catalytic activity on an artificial ( beta alpha )8-barrel protein designed from identical half-barrels.
Febs Lett., 587, 2013
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8BYW
 | | Rut B structure | | Descriptor: | Ureidoacrylate amidohydrolase RutB | | Authors: | Rajendran, C, Sterner, R, Busch, M. | | Deposit date: | 2022-12-14 | | Release date: | 2023-01-25 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.59 Å) | | Cite: | Structural and Functional Characterization of the Ureidoacrylate Amidohydrolase RutB from Escherichia coli .
Biochemistry, 62, 2023
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4EWN
 | | Structure of HisF-D130V+D176V with bound rCdRP | | Descriptor: | 1-(O-carboxy-phenylamino)-1-deoxy-D-ribulose-5-phosphate, Imidazole glycerol phosphate synthase subunit HisF | | Authors: | Reisinger, B, Bocola, M, Rajendran, C, List, F, Sterner, R. | | Deposit date: | 2012-04-27 | | Release date: | 2012-12-05 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.903 Å) | | Cite: | A sugar isomerization reaction established on various (beta-alpha)8-barrel scaffolds is based on substrate-assisted catalysis
Protein Eng.Des.Sel., 25, 2012
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4NAF
 | | PrcB from Geobacillus kaustophilus, apo structure | | Descriptor: | Heptaprenylglyceryl phosphate synthase | | Authors: | Peterhoff, D, Beer, B, Rajendran, C, Kumpula, E.P, Kapetaniou, E, Guldan, H, Wierenga, R.K, Sterner, R, Babinger, P. | | Deposit date: | 2013-10-22 | | Release date: | 2014-06-25 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | A comprehensive analysis of the geranylgeranylglyceryl phosphate synthase enzyme family identifies novel members and reveals mechanisms of substrate specificity and quaternary structure organization.
Mol.Microbiol., 92, 2014
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4NAE
 | | PcrB from Geobacillus kaustophilus, with bound G1P | | Descriptor: | 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, Heptaprenylglyceryl phosphate synthase, SN-GLYCEROL-1-PHOSPHATE | | Authors: | Peterhoff, D, Beer, B, Rajendran, C, Kumpula, E.P, Kapetaniou, E, Guldan, H, Wierenga, R.K, Sterner, R, Babinger, P. | | Deposit date: | 2013-10-22 | | Release date: | 2014-06-25 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | A comprehensive analysis of the geranylgeranylglyceryl phosphate synthase enzyme family identifies novel members and reveals mechanisms of substrate specificity and quaternary structure organization.
Mol.Microbiol., 92, 2014
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3ZR4
 | | STRUCTURAL EVIDENCE FOR AMMONIA TUNNELING ACROSS THE (BETA-ALPHA)8 BARREL OF THE IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE BIENZYME COMPLEX | | Descriptor: | GLUTAMINE, GLYCEROL, IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISF, ... | | Authors: | Vega, M.C, Kuper, J, Haeger, M.C, Mohrlueder, J, Marquardt, S, Sterner, R, Wilmanns, M. | | Deposit date: | 2011-06-13 | | Release date: | 2012-10-03 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.41 Å) | | Cite: | Catalysis Uncoupling in a Glutamine Amidotransferase Bienzyme by Unblocking the Glutaminase Active Site.
Chem.Biol., 19, 2012
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1GPW
 | | Structural evidence for ammonia tunneling across the (beta/alpha)8 barrel of the imidazole glycerol phosphate synthase bienzyme complex. | | Descriptor: | AMIDOTRANSFERASE HISH, HISF PROTEIN, PHOSPHATE ION | | Authors: | Walker, M, Beismann-Driemeyer, S, Sterner, R, Wilmanns, M. | | Deposit date: | 2001-11-12 | | Release date: | 2002-02-10 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural Evidence for Ammonia Tunneling Across the (Beta Alpha)(8) Barrel of the Imidazole Glycerol Phosphate Synthase Bienzyme Complex.
Structure, 10, 2002
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4QYS
 | | TrpB2 enzymes | | Descriptor: | (5-HYDROXY-4,6-DIMETHYLPYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE, PHOSPHOSERINE, PYRIDOXAL-5'-PHOSPHATE, ... | | Authors: | Busch, F, Rajendran, C, Loeffler, P, Merkl, R, Sterner, R. | | Deposit date: | 2014-07-25 | | Release date: | 2015-02-18 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.939 Å) | | Cite: | TrpB2 enzymes are O-phospho-l-serine dependent tryptophan synthases
Biochemistry, 53, 2014
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4EVZ
 | | Structure of HisF-LUCA | | Descriptor: | HYDROGENPHOSPHATE ION, HisF-LUCA | | Authors: | Reisinger, B, Sperl, J, Rajendran, C, Merkl, R, Sterner, R. | | Deposit date: | 2012-04-26 | | Release date: | 2013-11-06 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.462 Å) | | Cite: | Evidence for the existence of elaborate enzyme complexes in the Paleoarchean era.
J.Am.Chem.Soc., 136, 2014
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1QO2
 | | Crystal structure of N-((5'-phosphoribosyl)-formimino)-5-aminoimidazol-4-carboxamid ribonucleotid isomerase (EC 3.1.3.15, HisA) | | Descriptor: | | | Authors: | Wilmanns, M, Lang, D, Thoma, R, Sterner, R. | | Deposit date: | 1999-11-01 | | Release date: | 2000-07-12 | | Last modified: | 2019-07-24 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Structural Evidence for Evolution of the Beta/Alpha-Barrel Scaffold by Repeated Gene Duplication and Fusion
Science, 289, 2000
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7A20
 | | Azobenzene-Based Inhibitors for Tryptophan Synthase | | Descriptor: | SODIUM ION, TRIS-HYDROXYMETHYL-METHYL-AMMONIUM, Tryptophan synthase alpha chain,Tryptophan synthase beta chain | | Authors: | Rajendran, C, Sterner, R. | | Deposit date: | 2020-08-14 | | Release date: | 2020-11-04 | | Last modified: | 2024-05-15 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Towards Photochromic Azobenzene-Based Inhibitors for Tryptophan Synthase.
Chemistry, 27, 2021
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3GBR
 | | Anthranilate phosphoribosyl-transferase (TRPD) double mutant D83G F149S from S. solfataricus | | Descriptor: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, Anthranilate phosphoribosyltransferase, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Bruning, M, Schlee, S, Deuss, M, Ivens, A, Mayans, O, Sterner, R. | | Deposit date: | 2009-02-20 | | Release date: | 2009-12-15 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Activation of anthranilate phosphoribosyltransferase from Sulfolobus solfataricus by removal of magnesium inhibition and acceleration of product release
Biochemistry, 48, 2009
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2GVQ
 | | Anthranilate phosphoribosyl-transferase (TRPD) from S. solfataricus in complex with anthranilate | | Descriptor: | 2-AMINOBENZOIC ACID, Anthranilate phosphoribosyltransferase | | Authors: | Marino, M, Deuss, M, Sterner, R, Mayans, O. | | Deposit date: | 2006-05-03 | | Release date: | 2006-05-23 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.43 Å) | | Cite: | Structural and mutational analysis of substrate complexation by anthranilate phosphoribosyltransferase from Sulfolobus solfataricus.
J.Biol.Chem., 281, 2006
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6RTZ
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6RU0
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1DL3
 | | CRYSTAL STRUCTURE OF MUTUALLY GENERATED MONOMERS OF DIMERIC PHOSPHORIBOSYLANTRANILATE ISOMERASE FROM THERMOTOGA MARITIMA | | Descriptor: | PROTEIN (PHOSPHORIBOSYLANTRANILATE ISOMERASE), SULFATE ION | | Authors: | Thoma, R, Hennig, M, Sterner, R, Kirschner, K. | | Deposit date: | 1999-12-08 | | Release date: | 1999-12-27 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structure and function of mutationally generated monomers of dimeric phosphoribosylanthranilate isomerase from Thermotoga maritima.
Structure Fold.Des., 8, 2000
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2C3Z
 | | Crystal structure of a truncated variant of indole-3-glycerol phosphate synthase from Sulfolobus solfataricus | | Descriptor: | INDOLE-3-GLYCEROL PHOSPHATE SYNTHASE, SULFATE ION | | Authors: | Schneider, A, Knoechel, T, Darimont, B, Hennig, M, Dietrich, S, Kirschner, K, Sterner, R. | | Deposit date: | 2005-10-13 | | Release date: | 2005-10-13 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Role of the N-Terminal Extension of the (Betaalpha)(8)-Barrel Enzyme Indole-3-Glycerol Phosphate Synthase for its Fold, Stability, and Catalytic Activity.
Biochemistry, 44, 2005
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2CFF
 | | Crystal Structure Of N-((5'-Phosphoribosyl)-Formimino)-5- Aminoimidazol-4-Carboxamid Ribonucleotid Isomerase mutant D127V (Ec 3. 1.3.15, Hisa) | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO) METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE | | Authors: | He, C, Kuper, J, Sterner, R, Wilmmans, M. | | Deposit date: | 2006-02-20 | | Release date: | 2007-03-20 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal Structure of N-((5'-Phosphoribosyl)- Formimino)-5-Aminoimidazol-4-Carboxamid Ribonucleotid Isomerase Mutant D127V (Ec 3.1.3.15, Hisa)
To be Published
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1VJW
 | | STRUCTURE OF OXIDOREDUCTASE (NADP+(A),FERREDOXIN(A)) | | Descriptor: | FERREDOXIN(A), IRON/SULFUR CLUSTER | | Authors: | Macedo-Ribeiro, S, Darimont, B, Sterner, R, Huber, R. | | Deposit date: | 1996-10-09 | | Release date: | 1996-12-23 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Small structural changes account for the high thermostability of 1[4Fe-4S] ferredoxin from the hyperthermophilic bacterium Thermotoga maritima.
Structure, 4, 1996
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2W6R
 | | Crystal structure of an artificial (ba)8-barrel protein designed from identical half barrels | | Descriptor: | IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISF | | Authors: | Hocker, B, Lochner, A, Seitz, T, Claren, J, Sterner, R. | | Deposit date: | 2008-12-18 | | Release date: | 2009-02-03 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | High-Resolution Crystal Structure of an Artificial (Betaalpha)(8)-Barrel Protein Designed from Identical Half-Barrels.
Biochemistry, 48, 2009
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2W79
 | | Establishing wild-type levels of catalytic activity on natural and artificial (ba)8-barrel protein scaffolds | | Descriptor: | 1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO) METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE, CHLORIDE ION | | Authors: | Claren, J, Malisi, C, Hocker, B, Sterner, R. | | Deposit date: | 2008-12-21 | | Release date: | 2009-02-17 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Establishing Wild-Type Levels of Catalytic Activity on Natural and Artificial (Beta Alpha)8- Barrel Protein Scaffolds.
Proc.Natl.Acad.Sci.USA, 106, 2009
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2WJZ
 | | Crystal structure of (HisH) K181A Y138A mutant of imidazoleglycerolphosphate synthase (HisH HisF) which displays constitutive glutaminase activity | | Descriptor: | IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE HISF, IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISH, PHOSPHATE ION | | Authors: | Vega, M.C, List, F, Razeto, A, Haeger, M.C, Babinger, K, Kuper, J, Sterner, R, Wilmanns, M. | | Deposit date: | 2009-06-02 | | Release date: | 2010-08-25 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.601 Å) | | Cite: | Catalysis Uncoupling in a Glutamine Amidotransferase Bienzyme by Unblocking the Glutaminase Active Site.
Chem.Biol., 19, 2012
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