4PG3
 
 | | Crystal structure of KRS complexed with inhibitor | | Descriptor: | LYSINE, Lysine--tRNA ligase, cladosporin | | Authors: | Sharma, A, Yogavel, M, Khan, S, Sharma, A, Belrhali, H. | | Deposit date: | 2014-05-01 | | Release date: | 2014-07-16 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.696 Å) | | Cite: | Structural basis of malaria parasite lysyl-tRNA synthetase inhibition by cladosporin.
J. Struct. Funct. Genomics, 15, 2014
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7PJE
 | | Inhibiting parasite proliferation using a rationally designed anti-tubulin agent | | Descriptor: | Darpin D1, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Sharma, A, Gaillard, N, Ehrhard, V.A, Steinmetz, M.O. | | Deposit date: | 2021-08-24 | | Release date: | 2021-09-22 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Inhibiting parasite proliferation using a rationally designed anti-tubulin agent.
Embo Mol Med, 13, 2021
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7PJF
 | | Inhibiting parasite proliferation using a rationally designed anti-tubulin agent | | Descriptor: | Designed ankyrin repeat protein (DARPIN) D1, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Sharma, A, Gaillard, N, Ehrhard, V.A, Steinmetz, M.O. | | Deposit date: | 2021-08-24 | | Release date: | 2021-09-22 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.862 Å) | | Cite: | Inhibiting parasite proliferation using a rationally designed anti-tubulin agent.
Embo Mol Med, 13, 2021
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5CFJ
 | | Structural and functional attributes of malaria parasite Ap4A hydrolase | | Descriptor: | BIS(5'-nucleosyl)-tetraphosphatase (Diadenosine tetraphosphatase), putative, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Sharma, A, Yogavel, M, Sharma, A. | | Deposit date: | 2015-07-08 | | Release date: | 2016-02-10 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.25 Å) | | Cite: | Structural and functional attributes of malaria parasite diadenosine tetraphosphate hydrolase
Sci Rep, 6, 2016
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5CFI
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1FNH
 | | CRYSTAL STRUCTURE OF HEPARIN AND INTEGRIN BINDING SEGMENT OF HUMAN FIBRONECTIN | | Descriptor: | PROTEIN (FIBRONECTIN) | | Authors: | Sharma, A, Askari, J, Humphries, M, Jones, E.Y, Stuart, D.I. | | Deposit date: | 1999-01-28 | | Release date: | 1999-03-16 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Crystal structure of a heparin- and integrin-binding segment of human fibronectin.
EMBO J., 18, 1999
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3STN
 | | Structure of human LFABP (apo-LFABP) | | Descriptor: | Fatty acid-binding protein, liver | | Authors: | Sharma, A, Sharma, A. | | Deposit date: | 2011-07-11 | | Release date: | 2011-08-10 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.595 Å) | | Cite: | Fatty acid induced remodeling within the Human liver fatty acid binding protein
J.Biol.Chem., 2011
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3STM
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3STK
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6FLJ
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6FLK
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1VCC
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2K84
 | | Solution Structure of the equine infectious anemia virus p9 GAG protein | | Descriptor: | P9 | | Authors: | Sharma, A, Bruns, K, Roeder, R, Henklein, P, Votteler, J, Wray, V, Sharma, U. | | Deposit date: | 2008-09-02 | | Release date: | 2009-09-08 | | Last modified: | 2022-03-16 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the Equine Infectious Anemia Virus p9 protein: a rationalization of its different ALIX binding requirements compared to the analogous HIV-p6 protein
Bmc Struct.Biol., 9, 2009
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2W8B
 | | Crystal structure of processed TolB in complex with Pal | | Descriptor: | ACETATE ION, GLYCEROL, PEPTIDOGLYCAN-ASSOCIATED LIPOPROTEIN, ... | | Authors: | Sharma, A, Bonsor, D.A, Kleanthous, C. | | Deposit date: | 2009-01-15 | | Release date: | 2009-02-17 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.86 Å) | | Cite: | Allosteric Beta-Propeller Signalling in Tolb and its Manipulation by Translocating Colicins.
Embo J., 28, 2009
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6S8K
 | | Structure, Thermodynamics, and Kinetics of Plinabulin Binding to two Tubulin Isotypes | | Descriptor: | (3Z,6Z)-3-benzylidene-6-[(5-tert-butyl-1H-imidazol-4-yl)methylidene]piperazine-2,5-dione, Designed ankyrin repeat protein (DARPIN) D1, GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Sharma, A, Olieric, N, Steinmetz, M. | | Deposit date: | 2019-07-10 | | Release date: | 2019-11-27 | | Last modified: | 2024-05-15 | | Method: | X-RAY DIFFRACTION (1.52 Å) | | Cite: | Structure, Thermodynamics, and Kinetics of Plinabulin Binding to Two Tubulin Isotypes
Chem, 5, 2019
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3TED
 | | Crystal structure of the Chd1 DNA-binding domain in complex with a DNA duplex | | Descriptor: | 5'-D(*CP*CP*AP*TP*AP*TP*AP*TP*AP*TP*GP*C)-3', 5'-D(*GP*CP*AP*TP*AP*TP*AP*TP*AP*TP*GP*G)-3', Chromo domain-containing protein 1 | | Authors: | Sharma, A, Jenkins, K.R, Heroux, A, Bowman, G.D. | | Deposit date: | 2011-08-12 | | Release date: | 2011-11-02 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | DNA-binding domain of Chd1 in complex with a DNA duplex
J.Biol.Chem., 2011
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2OGW
 | | Structure of ABC type zinc transporter from E. coli | | Descriptor: | High-affinity zinc uptake system protein znuA precursor, ZINC ION | | Authors: | Sharma, A, Yogavel, M. | | Deposit date: | 2007-01-09 | | Release date: | 2007-03-06 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.83 Å) | | Cite: | Structural Analysis of ABC-family Periplasmic Zinc Binding Protein Provides New Insights Into Mechanism of Ligand Uptake and Release
J.Mol.Biol., 367, 2007
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4HR6
 | | Crystal structure of snake gourd (Trichosanthes anguina) seed lectin, a three chain homologue of type II RIPs | | Descriptor: | LECTIN, methyl alpha-D-galactopyranoside | | Authors: | Sharma, A, Pohlentz, G, Bobbili, K.B, Jeyaprakash, A.A, Chandran, T, Mormann, M, Swamy, M.J, Vijayan, M. | | Deposit date: | 2012-10-26 | | Release date: | 2013-08-07 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | The sequence and structure of snake gourd (Trichosanthes anguina) seed lectin, a three-chain nontoxic homologue of type II RIPs.
Acta Crystallogr.,Sect.D, 69, 2013
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4IR1
 | | Polymerase-DNA Complex | | Descriptor: | 5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]thymidine, DNA (5'-D(*CP*TP*AP*GP*GP*GP*TP*CP*CP*TP*AP*GP*GP*AP*CP*CP*C)-3'), DNA (5'-D(*GP*GP*GP*TP*CP*CP*TP*AP*GP*GP*AP*CP*CP*C)-3'), ... | | Authors: | Sharma, A, Nair, D.T. | | Deposit date: | 2013-01-14 | | Release date: | 2013-04-10 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.38 Å) | | Cite: | A strategically located serine residue is critical for the mutator activity of DNA polymerase IV from Escherichia coli.
Nucleic Acids Res., 41, 2013
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4IR9
 | | Polymerase-DNA complex | | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-D(P*CP*TP*AP*GP*GP*GP*TP*CP*CP*TP*AP*GP*GP*AP*CP*CP*C)-3'), DNA (5'-D(P*GP*GP*GP*TP*CP*CP*TP*AP*GP*GP*AP*CP*CP*C)-3'), ... | | Authors: | Sharma, A, Nair, D.T. | | Deposit date: | 2013-01-14 | | Release date: | 2013-04-17 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.33 Å) | | Cite: | A strategically located serine residue is critical for the mutator activity of DNA polymerase IV from Escherichia coli.
Nucleic Acids Res., 41, 2013
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3MIT
 | | Structure of Banana lectin-alpha-D-mannose complex | | Descriptor: | HEXANE-1,6-DIOL, Lectin, ZINC ION, ... | | Authors: | Sharma, A, Vijayan, M. | | Deposit date: | 2010-04-12 | | Release date: | 2010-09-08 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.32 Å) | | Cite: | Influence of glycosidic linkage on the nature of carbohydrate binding in beta-prism I fold lectins: an X-ray and molecular dynamics investigation on banana lectin-carbohydrate complexes
Glycobiology, 21, 2011
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3MIU
 | | Structure of Banana Lectin-pentamannose complex | | Descriptor: | HEXANE-1,6-DIOL, Lectin, ZINC ION, ... | | Authors: | Sharma, A, Vijayan, M. | | Deposit date: | 2010-04-12 | | Release date: | 2010-09-08 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.63 Å) | | Cite: | Influence of glycosidic linkage on the nature of carbohydrate binding in beta-prism I fold lectins: an X-ray and molecular dynamics investigation on banana lectin-carbohydrate complexes
Glycobiology, 21, 2011
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3MIV
 | | Structure of Banana lectin - Glc-alpha(1,2)-Glc complex | | Descriptor: | Lectin, ZINC ION | | Authors: | Sharma, A, Vijayan, M. | | Deposit date: | 2010-04-12 | | Release date: | 2010-09-08 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Influence of glycosidic linkage on the nature of carbohydrate binding in beta-prism I fold lectins: an X-ray and molecular dynamics investigation on banana lectin-carbohydrate complexes
Glycobiology, 21, 2011
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5NR4
 | | Crystal structure of Clasp2 TOG1 domain | | Descriptor: | CLIP-associating protein 2 | | Authors: | Sharma, A, Olieric, N, Weinert, T, Olieric, V, Steinmetz, M.O. | | Deposit date: | 2017-04-21 | | Release date: | 2018-05-30 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.198 Å) | | Cite: | CLASP Suppresses Microtubule Catastrophes through a Single TOG Domain.
Dev. Cell, 46, 2018
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5NJH
 | | Triazolopyrimidines stabilize microtubules by binding to the vinca inhibitor site of tubulin | | Descriptor: | 5-chloranyl-7-[(1~{R},5~{S})-3-methoxy-8-azabicyclo[3.2.1]octan-8-yl]-6-[2,4,6-tris(fluoranyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidine, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Sharma, A, Calvo, G.S, Prota, A.E, Diaz, J.F, Steinmetz, M.O. | | Deposit date: | 2017-03-28 | | Release date: | 2017-06-21 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.394 Å) | | Cite: | Triazolopyrimidines Are Microtubule-Stabilizing Agents that Bind the Vinca Inhibitor Site of Tubulin.
Cell Chem Biol, 24, 2017
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