PDB Search results for query - Protein Data Bank Japan

PDB: 2 results

ROCK2 IN COMPLEX WITH COMPOUND 12
Descriptor:	Rho-associated protein kinase 2, ~{N}-[(1~{R})-1-(3-methoxyphenyl)ethyl]-4-pyridin-4-yl-piperidine-1-carboxamide
Authors:	Maillard, M.C.
Deposit date:	2021-07-16
Release date:	2022-07-27
Last modified:	2023-08-09
Method:	X-RAY DIFFRACTION (3 Å)
Cite:	Identification of a Potent, Selective, and Brain-Penetrant Rho Kinase Inhibitor and its Activity in a Mouse Model of Huntington's Disease. J.Med.Chem., 65, 2022

Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class IIa histone deacetylase inhibitor
Descriptor:	(2~{S})-2-(2-fluorophenyl)-2-[4-(2-methylpyrimidin-5-yl)phenyl]-~{N}-oxidanyl-ethanamide, Histone deacetylase 4, SODIUM ION, ...
Authors:	Luckhurst, C.A, Maillard, M.C, Dominguez, C.
Deposit date:	2018-03-13
Release date:	2018-12-05
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (2.15 Å)
Cite:	Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class IIa histone deacetylase inhibitor. Bioorg. Med. Chem. Lett., 29, 2019