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PDB: 185 results
6YXJ
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BU of 6yxj by Molmil
Crystal structure of SARS-CoV macrodomain II in complex with human Paip1
Descriptor: Non-structural protein 3, Polyadenylate-binding protein-interacting protein 1
Authors:Lei, J, Hilgenfeld, R.
Deposit date:2020-05-02
Release date:2021-03-17
Last modified:2021-09-29
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:The SARS-unique domain (SUD) of SARS-CoV and SARS-CoV-2 interacts with human Paip1 to enhance viral RNA translation.
Embo J., 40, 2021
5LC0
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BU of 5lc0 by Molmil
Crystal structure of Zika virus NS2B-NS3 protease in complex with a boronate inhibitor
Descriptor: N-((S)-3-(4-(aminomethyl)phenyl)-1-(((R)-4-guanidino-1-(5-hydroxy-1,3,2-dioxaborinan-2-yl)butyl)amino)-1-oxopropan-2-yl)benzamide, NS2B-NS3 protease,NS2B-NS3 protease
Authors:Lei, J, Hansen, G, Zhang, L.L, Hilgenfeld, R.
Deposit date:2016-06-18
Release date:2016-07-06
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of Zika virus NS2B-NS3 protease in complex with a boronate inhibitor.
Science, 353, 2016
4WUR
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BU of 4wur by Molmil
The crystal structure of the MERS-CoV papain-like protease (C111S) with human ubiquitin
Descriptor: ISOPROPYL ALCOHOL, Papain-like protease, Polyubiquitin-B, ...
Authors:Lei, J, Hilgenfeld, R.
Deposit date:2014-11-03
Release date:2014-11-26
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.16 Å)
Cite:Structural and mutational analysis of the interaction between the Middle-East respiratory syndrome coronavirus (MERS-CoV) papain-like protease and human ubiquitin.
Virol Sin, 31, 2016
5NGN
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BU of 5ngn by Molmil
Lybatide 2, a cystine-rich peptide from Lycium barbarum
Descriptor: ACETONITRILE, GLYCEROL, TETRAETHYLENE GLYCOL, ...
Authors:Lei, J, Tan, W.L, Sakai, N, Hilgenfeld, R.
Deposit date:2017-03-18
Release date:2017-07-26
Last modified:2018-04-11
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Lybatides from Lycium barbarum Contain An Unusual Cystine-stapled Helical Peptide Scaffold.
Sci Rep, 7, 2017
3BJV
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BU of 3bjv by Molmil
The Crystal Structure of a putative PTS IIA(PtxA) from Streptococcus mutans
Descriptor: RmpA
Authors:Lei, J, Liang, Y.H, Su, X.D.
Deposit date:2007-12-04
Release date:2008-01-29
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structures of phosphotransferase system enzymes PtxB (IIB(Asc)) and PtxA (IIA(Asc)) from Streptococcus mutans
J.Mol.Biol., 386, 2009
5HOL
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BU of 5hol by Molmil
The crystal structure of the MERS-CoV macro domain with ADP-ribose
Descriptor: ADENOSINE-5-DIPHOSPHORIBOSE, ORF1a
Authors:Lei, J, Hilgenfeld, R.
Deposit date:2016-01-19
Release date:2016-01-27
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein.
Antiviral Res., 149, 2018
5HIH
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BU of 5hih by Molmil
Crystal structure of the macro domain in Middle-East Respiratory Syndrome Coronavirus
Descriptor: ORF1a
Authors:Lei, J, Hilgenfeld, R.
Deposit date:2016-01-11
Release date:2016-01-20
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Structural and mutational analysis of the interaction between the Middle-East respiratory syndrome coronavirus (MERS-CoV) papain-like protease and human ubiquitin.
Virol Sin, 31, 2016
3L8R
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BU of 3l8r by Molmil
The crystal structure of PtcA from S. mutans
Descriptor: Putative PTS system, cellobiose-specific IIA component
Authors:Lei, J, Liu, X, Li, L.
Deposit date:2010-01-03
Release date:2010-01-12
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The crystal structure of PtcA from Streptococcus mutans
To be Published
4P16
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BU of 4p16 by Molmil
Crystal structure of the papain-like protease of Middle-East Respiratory Syndrome coronavirus
Descriptor: ORF1a, ZINC ION
Authors:Lei, J, Mesters, J.R, Ma, Q, Hilgenfeld, R.
Deposit date:2014-02-25
Release date:2014-05-07
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of the papain-like protease of MERS coronavirus reveals unusual, potentially druggable active-site features.
Antiviral Res., 109C, 2014
3CZC
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BU of 3czc by Molmil
The Crystal Structure of a putative PTS IIB(PtxB) from Streptococcus mutans
Descriptor: RmpB
Authors:Lei, J, Su, X.D.
Deposit date:2008-04-29
Release date:2009-03-10
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Crystal structures of phosphotransferase system enzymes PtxB (IIB(Asc)) and PtxA (IIA(Asc)) from Streptococcus mutans
J.Mol.Biol., 386, 2009
3RK6
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BU of 3rk6 by Molmil
Crystal structure of the middle domain of human Paip1
Descriptor: Polyadenylate-binding protein-interacting protein 1
Authors:Lei, J, Mesters, J.R, Hilgenfeld, R.
Deposit date:2011-04-17
Release date:2011-05-18
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the middle domain of human poly(A)-binding protein-interacting protein 1.
Biochem.Biophys.Res.Commun., 408, 2011
7BX0
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BU of 7bx0 by Molmil
Crystal structure of RTT109 from Candida albicans
Descriptor: Histone acetyltransferase RTT109
Authors:Lei, J.H, Chen, Y.P, Lu, D.R, Su, D.
Deposit date:2020-04-16
Release date:2021-04-21
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of RTT109 from Candida albicans
To Be Published
7BXW
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BU of 7bxw by Molmil
Crystal structure ofF RTT109 FROM Candida albicans
Descriptor: ACETAMIDE, Histone acetyltransferase RTT109
Authors:Lei, J.H, Chen, Y.P, Lu, D.R, Su, D.
Deposit date:2020-04-21
Release date:2021-04-21
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.77629292 Å)
Cite:Crystal structure ofF RTT109 FROM Candida albicans
To be published
4V6K
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BU of 4v6k by Molmil
Structural insights into cognate vs. near-cognate discrimination during decoding.
Descriptor: 16S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ...
Authors:Agirrezabala, X, Schreiner, E, Trabuco, L.G, Lei, J, Ortiz-Meoz, R.F, Schulten, K, Green, R, Frank, J.
Deposit date:2011-01-07
Release date:2014-07-09
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (8.25 Å)
Cite:Structural insights into cognate versus near-cognate discrimination during decoding.
Embo J., 30, 2011
4V6L
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BU of 4v6l by Molmil
Structural insights into cognate vs. near-cognate discrimination during decoding.
Descriptor: 16S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ...
Authors:Agirrezabala, X, Schreiner, E, Trabuco, L.G, Lei, J, Ortiz-Meoz, R.F, Schulten, K, Green, R, Frank, J.
Deposit date:2011-01-07
Release date:2014-07-09
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (13.2 Å)
Cite:Structural insights into cognate versus near-cognate discrimination during decoding.
Embo J., 30, 2011
5XJC
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BU of 5xjc by Molmil
Cryo-EM structure of the human spliceosome just prior to exon ligation at 3.6 angstrom
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Zhang, X, Yan, C, Hang, J, Finci, I.L, Lei, J, Shi, Y.
Deposit date:2017-04-30
Release date:2017-07-05
Last modified:2020-10-14
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:An Atomic Structure of the Human Spliceosome
Cell, 169, 2017
8X52
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BU of 8x52 by Molmil
Cryo-EM structure of human gamma-secretase in complex with Abeta49
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Guo, X, Yan, C, Lei, J, Zhou, R, Shi, Y.
Deposit date:2023-11-16
Release date:2024-05-29
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Molecular mechanism of substrate recognition and cleavage by human gamma-secretase
Science, 2024
8X53
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BU of 8x53 by Molmil
Cryo-EM structure of human gamma-secretase in complex with Abeta46
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Guo, X, Yan, C, Lei, J, Zhou, R, Shi, Y.
Deposit date:2023-11-16
Release date:2024-05-29
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Molecular mechanism of substrate recognition and cleavage by human gamma-secretase
Science, 2024
8X54
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BU of 8x54 by Molmil
Cryo-EM structure of human gamma-secretase in complex with APP-C99
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Guo, X, Yan, C, Lei, J, Zhou, R, Shi, Y.
Deposit date:2023-11-16
Release date:2024-05-29
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Molecular mechanism of substrate recognition and cleavage by human gamma-secretase
Science, 2024
7C22
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BU of 7c22 by Molmil
Crystal structure of the C-terminal domain of SARS-CoV-2 nucleocapsid protein
Descriptor: ACETATE ION, DI(HYDROXYETHYL)ETHER, Nucleoprotein
Authors:Zhou, R.J, Zeng, R, Lei, J.
Deposit date:2020-05-07
Release date:2020-05-20
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural characterization of the C-terminal domain of SARS-CoV-2 nucleocapsid protein.
Mol Biomed, 1, 2020
8ILC
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BU of 8ilc by Molmil
Crystal structure of SetMet CoV-Y domain of Nsp3 in SARS-CoV-2
Descriptor: CHLORIDE ION, Papain-like protease nsp3, SULFATE ION
Authors:Wang, K, Nan, J, Lei, J.
Deposit date:2023-03-03
Release date:2023-05-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of SetMet CoV-Y domain of Nsp3 in SARS-CoV-2
To Be Published
7OXG
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BU of 7oxg by Molmil
ttSlyD FKBP domain with M8A pseudo-wild-type S2 peptide
Descriptor: 30S ribosomal protein S2, CHLORIDE ION, IMIDAZOLE, ...
Authors:Pazicky, S, Lei, J, Loew, C.
Deposit date:2021-06-22
Release date:2022-03-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:Impact of distant peptide substrate residues on enzymatic activity of SlyD.
Cell.Mol.Life Sci., 79, 2022
7OXJ
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BU of 7oxj by Molmil
ttSlyD with M8A pseudo-wild-type S2 peptide
Descriptor: 30S ribosomal protein S2, CHLORIDE ION, Fragment of 30S ribosomal protein S2 peptide, ...
Authors:Pazicky, S, Lei, J, Loew, C.
Deposit date:2021-06-22
Release date:2022-03-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Impact of distant peptide substrate residues on enzymatic activity of SlyD.
Cell.Mol.Life Sci., 79, 2022
7OXH
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BU of 7oxh by Molmil
ttSlyD with pseudo-wild-type S2 peptide
Descriptor: 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, 30S ribosomal protein S2, CHLORIDE ION, ...
Authors:Pazicky, S, Lei, J, Loew, C.
Deposit date:2021-06-22
Release date:2022-03-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Impact of distant peptide substrate residues on enzymatic activity of SlyD.
Cell.Mol.Life Sci., 79, 2022
8HFE
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BU of 8hfe by Molmil
Cryo-EM structure of human norepinephrine transporter NET in an inward-open state at resolution of 2.5 angstrom
Descriptor: CHLORIDE ION, Sodium-dependent noradrenaline transporter
Authors:Tan, J, Xiao, Y, Kong, F, Lei, J, Yuan, Y, Yan, C.
Deposit date:2022-11-10
Release date:2024-05-15
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Molecular basis for the reuptake and inhibition of human norepinephrine transporter
To Be Published

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