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PDB: 162 results

5MRU
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BU of 5mru by Molmil
TetR(class A) in complex with 5a,6-anhydrotetracycline and magnesium
Descriptor: 5A,6-ANHYDROTETRACYCLINE, MAGNESIUM ION, Tetracycline Repressor, ...
Authors:Hinrichs, W, Palm, G.J.
Deposit date:2016-12-26
Release date:2018-01-17
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:TetR(class A) in complex with 5a,6-anhydrotetracycline and magnesium
To Be Published
6QJX
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BU of 6qjx by Molmil
TetR(D) T103A mutant in complex with minocycline and magnesium
Descriptor: (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2- CARBOXAMIDE, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Hinrichs, W, Palm, G.J, Berndt, L, Girbardt, B.
Deposit date:2019-01-27
Release date:2019-08-21
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Thermodynamics, cooperativity and stability of the tetracycline repressor (TetR) upon tetracycline binding.
Biochim Biophys Acta Proteins Proteom, 1868, 2020
6QJW
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BU of 6qjw by Molmil
TetR(D) T103A mutant in complex with 7-chlortetracycline and magnesium
Descriptor: 7-CHLOROTETRACYCLINE, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Hinrichs, W, Palm, G.J, Berndt, L, Girbardt, B.
Deposit date:2019-01-27
Release date:2019-08-21
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Thermodynamics, cooperativity and stability of the tetracycline repressor (TetR) upon tetracycline binding.
Biochim Biophys Acta Proteins Proteom, 1868, 2020
6YR1
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BU of 6yr1 by Molmil
TetR(D) soaked with Tigecycline I4(1)22
Descriptor: CHLORIDE ION, MAGNESIUM ION, TIGECYCLINE, ...
Authors:Hinrichs, W, Stary, K.
Deposit date:2020-04-18
Release date:2021-04-28
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:TetR(D) soaked with Tigecycline
to be published
6YR2
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BU of 6yr2 by Molmil
TetR(D) soaked with Tigecycline P4(1)2(1)2
Descriptor: CHLORIDE ION, MAGNESIUM ION, SULFATE ION, ...
Authors:Hinrichs, W, Stary, K.
Deposit date:2020-04-19
Release date:2021-04-28
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:TetR(D) soaked with Tigecycline
to be published
6FPL
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BU of 6fpl by Molmil
TETR(D) E147A MUTANT IN COMPLEX WITH TETRACYCLINE AND MAGNESIUM
Descriptor: CHLORIDE ION, MAGNESIUM ION, TETRACYCLINE, ...
Authors:Hinrichs, W, Palm, G.J, Berndt, L, Girbardt, B.
Deposit date:2018-02-11
Release date:2019-03-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.602 Å)
Cite:Thermodynamics, cooperativity and stability of the tetracycline repressor (TetR) upon tetracycline binding.
Biochim Biophys Acta Proteins Proteom, 1868, 2020
6FPM
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BU of 6fpm by Molmil
TetR(D) T103A mutant in complex with tetracycline and magnesium
Descriptor: CHLORIDE ION, MAGNESIUM ION, TETRACYCLINE, ...
Authors:Hinrichs, W, Palm, G.J, Berndt, L, Girbardt, B.
Deposit date:2018-02-11
Release date:2019-03-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Thermodynamics, cooperativity and stability of the tetracycline repressor (TetR) upon tetracycline binding.
Biochim Biophys Acta Proteins Proteom, 1868, 2020
6FTS
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BU of 6fts by Molmil
TETR(D) N82A MUTANT IN COMPLEX WITH PEG4
Descriptor: CHLORIDE ION, TETRAETHYLENE GLYCOL, Tetracycline repressor protein class D
Authors:Hinrichs, W, Palm, G.J, Berndt, L, Girbardt, B.
Deposit date:2018-02-23
Release date:2019-02-20
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Thermodynamics, cooperativity and stability of the tetracycline repressor (TetR) upon tetracycline binding.
Biochim Biophys Acta Proteins Proteom, 1868, 2020
2TCT
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BU of 2tct by Molmil
THE COMPLEX FORMED BETWEEN TET REPRESSOR AND TETRACYCLINE-MG2+ REVEALS MECHANISM OF ANTIBIOTIC RESISTANCE
Descriptor: 7-CHLOROTETRACYCLINE, MAGNESIUM ION, TETRACYCLINE REPRESSOR
Authors:Hinrichs, W, Kisker, C, Saenger, W.
Deposit date:1995-03-02
Release date:1996-04-03
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The complex formed between Tet repressor and tetracycline-Mg2+ reveals mechanism of antibiotic resistance.
J.Mol.Biol., 247, 1995
8B7R
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BU of 8b7r by Molmil
Bacterial chalcone isomerase with taxifolin chalcone
Descriptor: (Z)-3-[3,4-bis(oxidanyl)phenyl]-2-oxidanyl-1-[2,4,6-tris(oxidanyl)phenyl]prop-2-en-1-one, CHLORIDE ION, Chalcone isomerase, ...
Authors:Hinrichs, W, Palm, G.J.
Deposit date:2022-10-02
Release date:2022-11-23
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural Basis for (2 R ,3 R )-Taxifolin Binding and Reaction Products to the Bacterial Chalcone Isomerase of Eubacterium ramulus .
Molecules, 27, 2022
8B7U
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BU of 8b7u by Molmil
Bacterial chalcone isomerase H33A with taxifolin
Descriptor: (2R,3R)-2-(3,4-DIHYDROXYPHENYL)-3,5,7-TRIHYDROXY-2,3-DIHYDRO-4H-CHROMEN-4-ONE, CHLORIDE ION, Chalcone isomerase, ...
Authors:Hinrichs, W, Palm, G.J.
Deposit date:2022-10-03
Release date:2022-11-23
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Basis for (2 R ,3 R )-Taxifolin Binding and Reaction Products to the Bacterial Chalcone Isomerase of Eubacterium ramulus .
Molecules, 27, 2022
6RGX
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BU of 6rgx by Molmil
TETR(D) N82A MUTANT IN COMPLEX WITH DOXYCYCLINE AND MAGNESIUM
Descriptor: (4S,4AR,5S,5AR,6R,12AS)-4-(DIMETHYLAMINO)-3,5,10,12,12A-PENTAHYDROXY-6-METHYL-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Hinrichs, W, Palm, G.J, Berndt, L, Girbardt, B.
Deposit date:2019-04-17
Release date:2019-08-21
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Thermodynamics, cooperativity and stability of the tetracycline repressor (TetR) upon tetracycline binding.
Biochim Biophys Acta Proteins Proteom, 1868, 2020
6RBM
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BU of 6rbm by Molmil
TETR(D) E147A MUTANT IN COMPLEX WITH MINOCYCLINE AND MAGNESIUM
Descriptor: (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2- CARBOXAMIDE, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Hinrichs, W, Palm, G.J, Berndt, L, Girbardt, B.
Deposit date:2019-04-11
Release date:2019-08-21
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Thermodynamics, cooperativity and stability of the tetracycline repressor (TetR) upon tetracycline binding.
Biochim Biophys Acta Proteins Proteom, 1868, 2020
6RCR
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BU of 6rcr by Molmil
TETR(D) H100A MUTANT IN COMPLEX WITH DOXYCYCLINE AND MAGNESIUM
Descriptor: (4S,4AR,5S,5AR,6R,12AS)-4-(DIMETHYLAMINO)-3,5,10,12,12A-PENTAHYDROXY-6-METHYL-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Hinrichs, W, Palm, G.J, Berndt, L, Girbardt, B.
Deposit date:2019-04-11
Release date:2019-08-21
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Thermodynamics, cooperativity and stability of the tetracycline repressor (TetR) upon tetracycline binding.
Biochim Biophys Acta Proteins Proteom, 1868, 2020
6RBL
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BU of 6rbl by Molmil
TETR(D) E147A MUTANT IN COMPLEX WITH DOXYCYCLINE AND MAGNESIUM
Descriptor: (4S,4AR,5S,5AR,6R,12AS)-4-(DIMETHYLAMINO)-3,5,10,12,12A-PENTAHYDROXY-6-METHYL-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Hinrichs, W, Palm, G.J, Berndt, L, Girbardt, B.
Deposit date:2019-04-10
Release date:2019-08-21
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Thermodynamics, cooperativity and stability of the tetracycline repressor (TetR) upon tetracycline binding.
Biochim Biophys Acta Proteins Proteom, 1868, 2020
2TRT
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BU of 2trt by Molmil
TETRACYCLINE REPRESSOR CLASS D
Descriptor: MAGNESIUM ION, TETRACYCLINE, TETRACYCLINE REPRESSOR CLASS D
Authors:Hinrichs, W, Kisker, C, Saenger, W.
Deposit date:1994-03-04
Release date:1996-06-20
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of the Tet repressor-tetracycline complex and regulation of antibiotic resistance.
Science, 264, 1994
1ORK
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BU of 1ork by Molmil
TET REPRESSOR, CLASS D IN COMPLEX WITH 9-(N,N-DIMETHYLGLYCYLAMIDO)-6-DEMETHYL-6-DEOXY-TETRACYCLINE
Descriptor: 9-(N,N-DIMETHYLGLYCYLAMIDO)-6-DEOXY-6-DEMETHYL-TETRACYCLINE, MAGNESIUM ION, TETRACYCLINE REPRESSOR
Authors:Orth, P, Schnappinger, D, Sum, P.-E, Ellestad, G.A, Hillen, W, Saenger, W, Hinrichs, W.
Deposit date:1998-05-21
Release date:1999-06-15
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the tet repressor in complex with a novel tetracycline, 9-(N,N-dimethylglycylamido)- 6-demethyl-6-deoxy-tetracycline.
J.Mol.Biol., 285, 1999
1QPI
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BU of 1qpi by Molmil
CRYSTAL STRUCTURE OF TETRACYCLINE REPRESSOR/OPERATOR COMPLEX
Descriptor: DNA (5'-D(*CP*CP*TP*AP*TP*CP*AP*AP*TP*GP*AP*TP*AP*GP*A)-3'), DNA (5'-D(*TP*CP*TP*AP*TP*CP*AP*TP*TP*GP*AP*TP*AP*GP*G)-3'), IMIDAZOLE, ...
Authors:Orth, P, Schnappinger, D, Hillen, W, Saenger, W, Hinrichs, W.
Deposit date:1999-05-25
Release date:2000-02-28
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis of gene regulation by the tetracycline inducible Tet repressor-operator system.
Nat.Struct.Biol., 7, 2000
4V08
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BU of 4v08 by Molmil
Inhibited dimeric pseudorabies virus protease pUL26N at 2 A resolution
Descriptor: CHLORIDE ION, DIISOPROPYL PHOSPHONATE, MAGNESIUM ION, ...
Authors:Zuehlsdorf, M, Werten, S, Palm, G.J, Hinrichs, W.
Deposit date:2014-09-11
Release date:2015-07-15
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Dimerization-Induced Allosteric Changes of the Oxyanion-Hole Loop Activate the Pseudorabies Virus Assemblin Pul26N, a Herpesvirus Serine Protease
Plos Pathog., 11, 2015
3PRK
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BU of 3prk by Molmil
INHIBITION OF PROTEINASE K BY METHOXYSUCCINYL-ALA-ALA-PRO-ALA-CHLOROMETHYL KETONE. AN X-RAY STUDY AT 2.2-ANGSTROMS RESOLUTION
Descriptor: CALCIUM ION, METHOXYSUCCINYL-ALA-ALA-PRO-ALA-CHLOROMETHYL KETONE, PROTEINASE K
Authors:Wolf, W.M, Bajorath, J, Mueller, A, Raghunathan, S, Singh, T.P, Hinrichs, W, Saenger, W.
Deposit date:1991-08-07
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Inhibition of proteinase K by methoxysuccinyl-Ala-Ala-Pro-Ala-chloromethyl ketone. An x-ray study at 2.2-A resolution.
J.Biol.Chem., 266, 1991
2PKC
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BU of 2pkc by Molmil
CRYSTAL STRUCTURE OF CALCIUM-FREE PROTEINASE K AT 1.5 ANGSTROMS RESOLUTION
Descriptor: PROTEINASE K, SODIUM ION
Authors:Mueller, A, Hinrichs, W, Wolf, W.M, Saenger, W.
Deposit date:1993-06-04
Release date:1994-01-31
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of calcium-free proteinase K at 1.5-A resolution.
J.Biol.Chem., 269, 1994
8R7M
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BU of 8r7m by Molmil
CTX-M14 in complex with boric acid and 1,2-diol boric ester
Descriptor: BORIC ACID, Beta-lactamase, GLYCEROL, ...
Authors:Werner, N, Prester, A, Hinrichs, W, Perbandt, M, Betzel, C.
Deposit date:2023-11-26
Release date:2024-01-17
Last modified:2024-07-17
Method:X-RAY DIFFRACTION (1 Å)
Cite:Time-resolved crystallography of boric acid binding to the active site serine of the beta-lactamase CTX-M-14 and subsequent 1,2-diol esterification.
Commun Chem, 7, 2024
5EFY
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BU of 5efy by Molmil
Apo-form of SCO3201
Descriptor: Putative tetR-family transcriptional regulator
Authors:Waack, P, Hinrichs, W.
Deposit date:2015-10-26
Release date:2016-11-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structures of free and ligand-bound forms of the TetR/AcrR-like regulator SCO3201 from Streptomyces coelicolor suggest a novel allosteric mechanism.
Febs J., 2022
4GUV
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BU of 4guv by Molmil
TetX derivatized with Xenon
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION, TetX2 protein, ...
Authors:Volkers, G, Palm, G.J, Panjikar, S, Hinrichs, W.
Deposit date:2012-08-29
Release date:2013-04-10
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.73 Å)
Cite:Putative dioxygen-binding sites and recognition of tigecycline and minocycline in the tetracycline-degrading monooxygenase TetX.
Acta Crystallogr.,Sect.D, 69, 2013
3ZWQ
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BU of 3zwq by Molmil
HYPERTHERMOPHILIC ESTERASE FROM THE ARCHEON PYROBACULUM CALIDIFONTIS
Descriptor: ALPHA/BETA HYDROLASE FOLD-3 DOMAIN PROTEIN
Authors:Palm, G.J, Bogdanovic, X, Hinrichs, W.
Deposit date:2011-08-02
Release date:2011-08-17
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Crystal Structure of an Esterase from the Hyperthermophilic Microorganism Pyrobaculum Calidifontis Va1 Supports Explanation of its Enantioselectivity.
Appl.Microbiol.Biotechnol., 91, 2011

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