5LNK
 
 | | Entire ovine respiratory complex I | | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, 4'-PHOSPHOPANTETHEINE, ... | | Authors: | Fiedorczuk, K, Letts, J.A, Kaszuba, K, Sazanov, L.A. | | Deposit date: | 2016-08-04 | | Release date: | 2016-11-23 | | Last modified: | 2021-06-02 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Atomic structure of the entire mammalian mitochondrial complex I.
Nature, 538, 2016
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7SV7
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7SVD
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8EIQ
 | | The complex of phosphorylated human delta F508 cystic fibrosis transmembrane conductance regulator (CFTR) with Trikafta [elexacaftor (VX-445), tezacaftor (VX-661), ivacaftor (VX-770)] and ATP/Mg | | Descriptor: | (6P)-N-(1,3-dimethyl-1H-pyrazole-4-sulfonyl)-6-[3-(3,3,3-trifluoro-2,2-dimethylpropoxy)-1H-pyrazol-1-yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide, ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL, ... | | Authors: | Fiedorczuk, K, Chen, J. | | Deposit date: | 2022-09-15 | | Release date: | 2022-10-19 | | Last modified: | 2022-11-23 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Molecular structures reveal synergistic rescue of Delta 508 CFTR by Trikafta modulators.
Science, 378, 2022
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7SVR
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8EJ1
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8EIO
 | | The complex of phosphorylated human delta F508 cystic fibrosis transmembrane conductance regulator (CFTR) with elexacaftor (VX-445), lumacaftor (VX-809) and ATP/Mg | | Descriptor: | (6P)-N-(1,3-dimethyl-1H-pyrazole-4-sulfonyl)-6-[3-(3,3,3-trifluoro-2,2-dimethylpropoxy)-1H-pyrazol-1-yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide, ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL, ... | | Authors: | Fiedorczuk, K, Chen, J. | | Deposit date: | 2022-09-15 | | Release date: | 2022-10-19 | | Last modified: | 2022-11-23 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Molecular structures reveal synergistic rescue of Delta 508 CFTR by Trikafta modulators.
Science, 378, 2022
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8EIG
 | | The complex of phosphorylated human delta F508 cystic fibrosis transmembrane conductance regulator (CFTR) with elexacaftor (VX-445) and ATP/Mg | | Descriptor: | (6P)-N-(1,3-dimethyl-1H-pyrazole-4-sulfonyl)-6-[3-(3,3,3-trifluoro-2,2-dimethylpropoxy)-1H-pyrazol-1-yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide, ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL, ... | | Authors: | Fiedorczuk, K, Chen, J. | | Deposit date: | 2022-09-15 | | Release date: | 2022-10-19 | | Last modified: | 2022-11-23 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Molecular structures reveal synergistic rescue of Delta 508 CFTR by Trikafta modulators.
Science, 378, 2022
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8UBR
 | | Complex of the phosphorylated human cystic fibrosis transmembrane conductance regulator (CFTR) with CFTRinh-172 and ATP/Mg | | Descriptor: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 4-[(Z)-{(3M)-4-oxo-2-sulfanylidene-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene}methyl]benzoic acid, ADENOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Young, P.G, Fiedorczuk, K, Chen, J. | | Deposit date: | 2023-09-24 | | Release date: | 2024-02-21 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Structural basis for CFTR inhibition by CFTR inh -172.
Proc.Natl.Acad.Sci.USA, 121, 2024
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4WT8
 | | Crystal Structure of bactobolin A bound to 70S ribosome-tRNA complex | | Descriptor: | 23S rRNA (2899-MER), 30S ribosomal protein S10, 30S ribosomal protein S11, ... | | Authors: | Amunts, A, Fiedorczuk, K, Ramakrishnan, V. | | Deposit date: | 2014-10-29 | | Release date: | 2015-01-21 | | Last modified: | 2018-07-18 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | Bactobolin A Binds to a Site on the 70S Ribosome Distinct from Previously Seen Antibiotics.
J.Mol.Biol., 427, 2015
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5J4Z
 | | Architecture of tight respirasome | | Descriptor: | COMPLEX I 13KDA/NDUFS6, COMPLEX I 15KDA/NDUFS5, COMPLEX I 18KDA/NDUFS6, ... | | Authors: | Letts, J.A, Fiedorczuk, K, Sazanov, L.A. | | Deposit date: | 2016-04-01 | | Release date: | 2016-09-21 | | Last modified: | 2019-12-11 | | Method: | ELECTRON MICROSCOPY (5.8 Å) | | Cite: | The architecture of respiratory supercomplexes.
Nature, 537, 2016
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5J8K
 | | Architecture of supercomplex I-III2 | | Descriptor: | COMPLEX I 13KDA/NDUFS6, COMPLEX I 15KDA/NDUFS5, COMPLEX I 18KDA/NDUFS6, ... | | Authors: | Letts, J.A, Fiedorczuk, K, Sazanov, L.A. | | Deposit date: | 2016-04-08 | | Release date: | 2016-09-21 | | Last modified: | 2019-12-11 | | Method: | ELECTRON MICROSCOPY (7.8 Å) | | Cite: | The architecture of respiratory supercomplexes.
Nature, 537, 2016
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