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PDB: 14 results
6E1O
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BU of 6e1o by Molmil
afTMEM16 reconstituted in nanodiscs in the presence of Ca2+ and ceramide 24:0
Descriptor: CALCIUM ION, DECANE, DODECANE, ...
Authors:Falzone, M.E, Accardi, A.
Deposit date:2018-07-10
Release date:2019-02-06
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.59 Å)
Cite:Structural basis of Ca2+-dependent activation and lipid transport by a TMEM16 scramblase.
Elife, 8, 2019
6E0H
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BU of 6e0h by Molmil
PDB: afTMEM16 reconstituted in nanodiscs in the presence of Ca2+
Descriptor: CALCIUM ION, Plasma membrane channel protein (Aqy1), putative
Authors:Falzone, M.E, Accardi, A.
Deposit date:2018-07-06
Release date:2019-02-06
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (4.05 Å)
Cite:Structural basis of Ca2+-dependent activation and lipid transport by a TMEM16 scramblase.
Elife, 8, 2019
6DZ7
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BU of 6dz7 by Molmil
afTMEM16 reconstituted in nanodiscs in the absence of Ca2+
Descriptor: Plasma membrane channel protein (Aqy1), putative
Authors:Falzone, M.E, Accardi, A.
Deposit date:2018-07-03
Release date:2019-02-06
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.89 Å)
Cite:Structural basis of Ca2+-dependent activation and lipid transport by a TMEM16 scramblase.
Elife, 8, 2019
6OY3
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BU of 6oy3 by Molmil
nhTMEM16 L302A +Ca2+ in nanodiscs
Descriptor: CALCIUM ION, nhTMEM16
Authors:Falzone, M, Lee, B.C, Accardi, A.
Deposit date:2019-05-14
Release date:2019-11-06
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Dynamic modulation of the lipid translocation groove generates a conductive ion channel in Ca 2+ -bound nhTMEM16.
Nat Commun, 10, 2019
7RXG
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BU of 7rxg by Molmil
afTMEM16 in C18 lipid nanodiscs with MSP1E3 scaffold protein in the presence of Ca2+, full dimer
Descriptor: (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, CALCIUM ION, afTMEM16 lipid scramblase
Authors:Falzone, M.E, Accardi, A.
Deposit date:2021-08-23
Release date:2022-05-18
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (2.28 Å)
Cite:TMEM16 scramblases thin the membrane to enable lipid scrambling.
Nat Commun, 13, 2022
7RX2
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BU of 7rx2 by Molmil
afTMEM16 in C22 lipid nanodiscs with MSP1E3 scaffold protein in the presnece of Ca2+
Descriptor: (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, CALCIUM ION, afTMEM16 lipid scramblase
Authors:Falzone, M.E, Accardi, A.
Deposit date:2021-08-21
Release date:2022-05-18
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:TMEM16 scramblases thin the membrane to enable lipid scrambling.
Nat Commun, 13, 2022
7RXH
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BU of 7rxh by Molmil
afTMEM16 in C18 lipid nanodiscs with MSP1E3 scaffold protein in the presence of Ca2+, monomer with extra lipids
Descriptor: (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, CALCIUM ION, afTMEM16 lipid scramblase
Authors:Falzone, M.E, Accardi, A.
Deposit date:2021-08-23
Release date:2022-05-18
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (2.3 Å)
Cite:TMEM16 scramblases thin the membrane to enable lipid scrambling.
Nat Commun, 13, 2022
7RX3
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BU of 7rx3 by Molmil
afTMEM16 in C14 lipid nanodiscs with MSP1E3 scaffold protein in the absence of Ca2+
Descriptor: (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, afTMEM16 lipid scramblase
Authors:Falzone, M.E, Accardi, A.
Deposit date:2021-08-21
Release date:2022-05-18
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:TMEM16 scramblases thin the membrane to enable lipid scrambling.
Nat Commun, 13, 2022
7RWJ
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BU of 7rwj by Molmil
afTMEM16 in C22 lipid nanodiscs with MSP2N2 scaffold protein in the presnece of Ca2+
Descriptor: (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, CALCIUM ION, Plasma membrane channel protein (Aqy1), ...
Authors:Falzone, M.E, Accardi, A.
Deposit date:2021-08-20
Release date:2022-05-18
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:TMEM16 scramblases thin the membrane to enable lipid scrambling.
Nat Commun, 13, 2022
8UQO
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BU of 8uqo by Molmil
PLCb3-Gbg-Gaq complex on membranes
Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Falzone, M.E, MacKinnon, R.
Deposit date:2023-10-24
Release date:2023-12-06
Method:ELECTRON MICROSCOPY (3.37 Å)
Cite:The mechanism of G alpha q regulation of PLC beta 3 -catalyzed PIP2 hydrolysis.
Proc.Natl.Acad.Sci.USA, 120, 2023
8UQN
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BU of 8uqn by Molmil
PLCb3-Gaq complex on membranes
Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Falzone, M.E, MacKinnon, R.
Deposit date:2023-10-24
Release date:2023-12-06
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:The mechanism of G alpha q regulation of PLC beta 3 -catalyzed PIP2 hydrolysis.
Proc.Natl.Acad.Sci.USA, 120, 2023
8EMV
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BU of 8emv by Molmil
Phospholipase C beta 3 (PLCb3) in solution
Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, CALCIUM ION
Authors:Falzone, M.E, MacKinnon, R.
Deposit date:2022-09-28
Release date:2023-05-24
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:G beta gamma activates PIP2 hydrolysis by recruiting and orienting PLC beta on the membrane surface.
Proc.Natl.Acad.Sci.USA, 120, 2023
8EMX
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BU of 8emx by Molmil
Phospholipase C beta 3 (PLCb3) in complex with Gbg on lipid nanodiscs
Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Falzone, M.E, MacKinnon, R.
Deposit date:2022-09-28
Release date:2023-05-24
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:G beta gamma activates PIP2 hydrolysis by recruiting and orienting PLC beta on the membrane surface.
Proc.Natl.Acad.Sci.USA, 120, 2023
8EMW
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BU of 8emw by Molmil
Phospholipase C beta 3 (PLCb3) in complex with Gbg on liposomes
Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Falzone, M.E, MacKinnon, R.
Deposit date:2022-09-28
Release date:2023-05-24
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:G beta gamma activates PIP2 hydrolysis by recruiting and orienting PLC beta on the membrane surface.
Proc.Natl.Acad.Sci.USA, 120, 2023

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