2OYY
 
 | | HTHP: a hexameric tyrosine-coordinated heme protein | | Descriptor: | Hexameric cytochrome, IODIDE ION, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Dobbek, H. | | Deposit date: | 2007-02-23 | | Release date: | 2007-04-10 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | HTHP: A Novel Class of Hexameric, Tyrosine-coordinated Heme Proteins
J.Mol.Biol., 368, 2007
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1N62
 | | Crystal Structure of the Mo,Cu-CO Dehydrogenase (CODH), n-butylisocyanide-bound state | | Descriptor: | CU(I)-S-MO(IV)(=O)O-NBIC CLUSTER, Carbon monoxide dehydrogenase large chain, Carbon monoxide dehydrogenase medium chain, ... | | Authors: | Dobbek, H, Gremer, L, Kiefersauer, R, Huber, R, Meyer, O. | | Deposit date: | 2002-11-08 | | Release date: | 2002-12-18 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.09 Å) | | Cite: | Catalysis at a dinuclear [CuSMo(=O)OH] cluster in a CO dehydrogenase resolved at 1.1-A resolution
Proc.Natl.Acad.Sci.USA, 99, 2002
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1N60
 | | Crystal Structure of the Cu,Mo-CO Dehydrogenase (CODH); Cyanide-inactivated Form | | Descriptor: | Carbon monoxide dehydrogenase large chain, Carbon monoxide dehydrogenase medium chain, Carbon monoxide dehydrogenase small chain, ... | | Authors: | Dobbek, H, Gremer, L, Kiefersauer, R, Huber, R, Meyer, O. | | Deposit date: | 2002-11-08 | | Release date: | 2002-12-18 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.19 Å) | | Cite: | Catalysis at a dinuclear [CuSMo(=O)OH] cluster in a CO dehydrogenase resolved at 1.1-A resolution
Proc.Natl.Acad.Sci.USA, 99, 2002
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1N5W
 | | Crystal Structure of the Cu,Mo-CO Dehydrogenase (CODH); Oxidized form | | Descriptor: | CU(I)-S-MO(VI)(=O)OH CLUSTER, Carbon monoxide dehydrogenase large chain, Carbon monoxide dehydrogenase medium chain, ... | | Authors: | Dobbek, H, Gremer, L, Kiefersauer, R, Huber, R, Meyer, O. | | Deposit date: | 2002-11-07 | | Release date: | 2002-12-23 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Catalysis at a dinuclear [CuSMo(=O)OH] cluster in a CO dehydrogenase resolved at 1.1-A resolution
Proc.Natl.Acad.Sci.USA, 99, 2002
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1N63
 | | Crystal Structure of the Cu,Mo-CO Dehydrogenase (CODH); Carbon monoxide reduced state | | Descriptor: | CU(I)-S-MO(IV)(=O)OH CLUSTER, Carbon monoxide dehydrogenase large chain, Carbon monoxide dehydrogenase medium chain, ... | | Authors: | Dobbek, H, Gremer, L, Kiefersauer, R, Huber, R, Meyer, O. | | Deposit date: | 2002-11-08 | | Release date: | 2002-12-18 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.21 Å) | | Cite: | Catalysis at a dinuclear [CuSMo(=O)OH] cluster in a CO dehydrogenase resolved at 1.1-A resolution
Proc.Natl.Acad.Sci.USA, 99, 2002
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1N61
 | | Crystal Structure of the Cu,Mo-CO Dehydrogenase (CODH); Dithionite reduced state | | Descriptor: | CU(I)-S-MO(IV)(=O)OH CLUSTER, Carbon monoxide dehydrogenase large chain, Carbon monoxide dehydrogenase medium chain, ... | | Authors: | Dobbek, H, Gremer, L, Kiefersauer, R, Huber, R, Meyer, O. | | Deposit date: | 2002-11-08 | | Release date: | 2002-12-18 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Catalysis at a dinuclear [CuSMo(=O)OH] cluster in a CO dehydrogenase resolved at 1.1-A resolution
Proc.Natl.Acad.Sci.USA, 99, 2002
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6T7J
 | | As-isolated Ni-free crystal structure of carbon monoxide dehydrogenase from Thermococcus sp. AM4 produced without CooC maturase | | Descriptor: | (R,R)-2,3-BUTANEDIOL, Broken Fe4S4 cluster, CITRIC ACID, ... | | Authors: | Dobbek, H, Jeoung, J.-H. | | Deposit date: | 2019-10-22 | | Release date: | 2020-11-18 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.43 Å) | | Cite: | The two CO-dehydrogenases of Thermococcus sp. AM4.
Biochim Biophys Acta Bioenerg, 1861, 2020
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2IHR
 | | RF2 of Thermus thermophilus | | Descriptor: | Peptide chain release factor 2 | | Authors: | Dobbek, H, Voertler, C.S, Sprinzl, M. | | Deposit date: | 2006-09-27 | | Release date: | 2007-02-20 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Release factors 2 from Escherichia coli and Thermus thermophilus: structural, spectroscopic and microcalorimetric studies.
Nucleic Acids Res., 35, 2007
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2H90
 | | Xenobiotic reductase A in complex with coumarin | | Descriptor: | (R,R)-2,3-BUTANEDIOL, COUMARIN, FLAVIN MONONUCLEOTIDE, ... | | Authors: | Dobbek, H. | | Deposit date: | 2006-06-08 | | Release date: | 2006-08-29 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.42 Å) | | Cite: | Xenobiotic reductase A in the degradation of quinoline by Pseudomonas putida 86: physiological function, structure and mechanism of 8-hydroxycoumarin reduction.
J.Mol.Biol., 361, 2006
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2H8Z
 | | Xenobiotic Reductase A in complex with 8-Hydroxycoumarin | | Descriptor: | 8-HYDROXYCOUMARIN, FLAVIN MONONUCLEOTIDE, SULFATE ION, ... | | Authors: | Dobbek, H. | | Deposit date: | 2006-06-08 | | Release date: | 2006-08-29 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.42 Å) | | Cite: | Xenobiotic reductase A in the degradation of quinoline by Pseudomonas putida 86: physiological function, structure and mechanism of 8-hydroxycoumarin reduction.
J.Mol.Biol., 361, 2006
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2H9A
 | | Corrinoid Iron-Sulfur Protein | | Descriptor: | CO dehydrogenase/acetyl-CoA synthase, iron-sulfur protein, COBALAMIN, ... | | Authors: | Dobbek, H. | | Deposit date: | 2006-06-09 | | Release date: | 2006-09-26 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural insights into methyltransfer reactions of a corrinoid iron-sulfur protein involved in acetyl-CoA synthesis.
Proc.Natl.Acad.Sci.Usa, 103, 2006
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2H8X
 | | Xenobiotic Reductase A-oxidized | | Descriptor: | FLAVIN MONONUCLEOTIDE, SULFATE ION, Xenobiotic reductase A | | Authors: | Dobbek, H. | | Deposit date: | 2006-06-08 | | Release date: | 2006-08-29 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Xenobiotic reductase A in the degradation of quinoline by Pseudomonas putida 86: physiological function, structure and mechanism of 8-hydroxycoumarin reduction.
J.Mol.Biol., 361, 2006
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1SU7
 | | Carbon Monoxide Dehydrogenase from Carboxydothermus hydrogenoformans- DTT reduced state | | Descriptor: | Carbon monoxide dehydrogenase 2, FE(4)-NI(1)-S(5) CLUSTER, FE2/S2 (INORGANIC) CLUSTER, ... | | Authors: | Dobbek, H, Svetlitchnyi, V, Liss, J, Meyer, O. | | Deposit date: | 2004-03-26 | | Release date: | 2004-05-11 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.12 Å) | | Cite: | Carbon Monoxide Induced Decomposition of the Active Site [Ni-4Fe-5S] Cluster of CO Dehydrogenase
J.Am.Chem.Soc., 126, 2004
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1SU6
 | | Carbon monoxide dehydrogenase from Carboxydothermus hydrogenoformans: CO reduced state | | Descriptor: | Carbon monoxide dehydrogenase 2, FE(4)-NI(1)-S(5) CLUSTER, FE2/S2 (INORGANIC) CLUSTER, ... | | Authors: | Dobbek, H, Svetlitchnyi, V, Liss, J, Meyer, O. | | Deposit date: | 2004-03-26 | | Release date: | 2004-05-11 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.64 Å) | | Cite: | Carbon Monoxide Induced Decomposition of the Active Site [Ni-4Fe-5S] Cluster of CO Dehydrogenase
J.Am.Chem.Soc., 126, 2004
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1SU8
 | | Carbon Monoxide Induced Decomposition of the Active Site [Ni-4Fe-5S] Cluster of CO Dehydrogenase | | Descriptor: | Carbon monoxide dehydrogenase 2, FE(4)-NI(1)-S(5) CLUSTER, FE2/S2 (INORGANIC) CLUSTER, ... | | Authors: | Dobbek, H, Svetlitchnyi, V, Liss, J, Meyer, O. | | Deposit date: | 2004-03-26 | | Release date: | 2004-05-11 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.1 Å) | | Cite: | Carbon Monoxide Induced Decomposition of the Active Site [Ni-4Fe-5S] Cluster of CO Dehydrogenase
J.Am.Chem.Soc., 126, 2004
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1SUF
 | | Carbon Monoxide Dehydrogenase from Carboxydothermus hydrogenoformans-Inactive state | | Descriptor: | Carbon Monoxide Dehydrogenase 2, FE(4)-NI(1)-S(5) CLUSTER, FE2/S2 (INORGANIC) CLUSTER, ... | | Authors: | Dobbek, H, Svetlitchnyi, V, Liss, J, Meyer, O. | | Deposit date: | 2004-03-26 | | Release date: | 2004-05-11 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.15 Å) | | Cite: | Carbon Monoxide Induced Decomposition of the Active Site [Ni-4Fe-5S] Cluster of CO Dehydrogenase
J.Am.Chem.Soc., 126, 2004
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3N14
 | | XenA - W358A | | Descriptor: | (R,R)-2,3-BUTANEDIOL, FLAVIN MONONUCLEOTIDE, SULFATE ION, ... | | Authors: | Dobbek, H, Spiegelhauer, O. | | Deposit date: | 2010-05-15 | | Release date: | 2010-09-22 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Determinants of substrate binding and protonation in the flavoenzyme xenobiotic reductase A
J.Mol.Biol., 403, 2010
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4UTI
 | | XenA - oxidized - Y183F variant in complex with coumarin | | Descriptor: | COUMARIN, FLAVIN MONONUCLEOTIDE, NADH:flavin oxidoreductase, ... | | Authors: | Werther, T, Dobbek, H. | | Deposit date: | 2014-07-21 | | Release date: | 2015-08-05 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.099 Å) | | Cite: | Redox-dependent substrate-cofactor interactions in the Michaelis-complex of a flavin-dependent oxidoreductase
Nat Commun, 8, 2017
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4UTK
 | | XenA - reduced - Y183F variant | | Descriptor: | 1-DEOXY-1-(7,8-DIMETHYL-2,4-DIOXO-3,4-DIHYDRO-2H-BENZO[G]PTERIDIN-1-ID-10(5H)-YL)-5-O-PHOSPHONATO-D-RIBITOL, SULFATE ION, XENOBIOTIC REDUCTASE | | Authors: | Werther, T, Dobbek, H. | | Deposit date: | 2014-07-21 | | Release date: | 2015-08-05 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.44 Å) | | Cite: | Redox-dependent substrate-cofactor interactions in the Michaelis-complex of a flavin-dependent oxidoreductase
Nat Commun, 8, 2017
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7YZM
 | | MgADPNP-bound DCCP:DCCP-R complex | | Descriptor: | (R,R)-2,3-BUTANEDIOL, AMMONIUM ION, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Jeoung, J.-H, Dobbek, H. | | Deposit date: | 2022-02-21 | | Release date: | 2022-12-28 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.82 Å) | | Cite: | Structural basis for coupled ATP-driven electron transfer in the double-cubane cluster protein.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7YYL
 | | nucleotide-free DCCP:DCCP-R complex | | Descriptor: | Dehydratase family protein, Double cubane cluster, IRON/SULFUR CLUSTER, ... | | Authors: | Jeoung, J.-H, Dobbek, H. | | Deposit date: | 2022-02-18 | | Release date: | 2022-12-28 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (3.25 Å) | | Cite: | Structural basis for coupled ATP-driven electron transfer in the double-cubane cluster protein.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7YZQ
 | | MgADP-AlF4-bound DCCP:DCCP-R complex | | Descriptor: | (R,R)-2,3-BUTANEDIOL, ADENOSINE-5'-DIPHOSPHATE, AMMONIUM ION, ... | | Authors: | Jeoung, J.-H, Dobbek, H. | | Deposit date: | 2022-02-21 | | Release date: | 2022-12-28 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.96 Å) | | Cite: | Structural basis for coupled ATP-driven electron transfer in the double-cubane cluster protein.
Proc.Natl.Acad.Sci.USA, 119, 2022
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5FLI
 | | enzyme-substrate complex of Ni-quercetinase | | Descriptor: | 3,5,7,3',4'-PENTAHYDROXYFLAVONE, NICKEL (II) ION, QUERCETINASE QUED | | Authors: | Jeoung, J.-H, Nianios, D, Fetzner, S, Dobbek, H. | | Deposit date: | 2015-10-26 | | Release date: | 2016-06-01 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Quercetin 2,4-Dioxygenase Activates Dioxygen in a Side-On O2-Ni Complex.
Angew. Chem. Int. Ed. Engl., 55, 2016
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5FLE
 | | High resolution NI,FE-CODH-320 mV with CN state | | Descriptor: | CARBON MONOXIDE DEHYDROGENASE 2, FE (II) ION, FE2/S2 (INORGANIC) CLUSTER, ... | | Authors: | Ciaccafava, A, Tombolelli, D, Domnik, L, Fesseler, J, Jeoung, J.-H, Dobbek, H, Mroginski, M.A, Hildebrandt, P, Zebger, I. | | Deposit date: | 2015-10-26 | | Release date: | 2016-09-14 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.23 Å) | | Cite: | When the inhibitor tells more than the substrate: the cyanide-bound state of a carbon monoxide dehydrogenase.
Chem Sci, 7, 2016
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8CAV
 | | Discovery of the lanthipeptide Curvocidin and structural insights into its trifunctional synthetase CuvL | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CuvA, MAGNESIUM ION, ... | | Authors: | Sigurdsson, A, Martins, B.M, Duettmann, S.A, Jasyk, M, Dimos-Roehl, B, Schoepf, F, Gemannter, M, Knittel, C.H, Schnegotyzki, R, Schmid, B, Kosol, S, Gonzalez-Viegas, M, Seidel, M, Huegelland, M, Leimkuehler, S, Dobbek, H, Mainz, A, Suessmuth, R. | | Deposit date: | 2023-01-24 | | Release date: | 2023-06-14 | | Method: | X-RAY DIFFRACTION (2.87 Å) | | Cite: | Discovery of the Lanthipeptide Curvocidin and Structural Insights into its Trifunctional Synthetase CuvL.
Angew.Chem.Int.Ed.Engl., 62, 2023
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