8CAV

Discovery of the lanthipeptide Curvocidin and structural insights into its trifunctional synthetase CuvL

Summary for 8CAV

Entry DOI	10.2210/pdb8cav/pdb
Descriptor	Serine/threonine protein kinase, CuvA, (4S)-2-METHYL-2,4-PENTANEDIOL, ... (6 entities in total)
Functional Keywords	lanthipeptide, biosynthetic protein
Biological source	Thermomonospora curvata More
Total number of polymer chains	4
Total formula weight	198434.05
Authors	Sigurdsson, A.,Martins, B.M.,Duettmann, S.A.,Jasyk, M.,Dimos-Roehl, B.,Schoepf, F.,Gemannter, M.,Knittel, C.H.,Schnegotyzki, R.,Schmid, B.,Kosol, S.,Gonzalez-Viegas, M.,Seidel, M.,Huegelland, M.,Leimkuehler, S.,Dobbek, H.,Mainz, A.,Suessmuth, R. (deposition date: 2023-01-24, release date: 2023-06-14)
Primary citation	Sigurdsson, A.,Martins, B.M.,Duttmann, S.A.,Jasyk, M.,Dimos-Rohl, B.,Schopf, F.,Gemander, M.,Knittel, C.H.,Schnegotzki, R.,Schmid, B.,Kosol, S.,Pommerening, L.,Gonzales-Viegaz, M.,Seidel, M.,Hugelland, M.,Leimkuhler, S.,Dobbek, H.,Mainz, A.,Sussmuth, R.D. Discovery of the Lanthipeptide Curvocidin and Structural Insights into its Trifunctional Synthetase CuvL. Angew.Chem.Int.Ed.Engl., 62:e202302490-e202302490, 2023 Cited by PubMed: 37014271 DOI: 10.1002/anie.202302490 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.87 Å)

Structure validation