5YQG
| The structure of 14-3-3 and pNumb peptide | Descriptor: | 14-3-3 protein eta, Peptide from Protein numb homolog | Authors: | Chen, X, Liu, Z, Wen, W. | Deposit date: | 2017-11-06 | Release date: | 2018-02-07 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural determinants controlling 14-3-3 recruitment to the endocytic adaptor Numb and dissociation of the Numb/alpha-adaptin complex. J. Biol. Chem., 293, 2018
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6MUN
| Structure of hRpn10 bound to UBQLN2 UBL | Descriptor: | 26S proteasome non-ATPase regulatory subunit 4, Ubiquilin-2 | Authors: | Chen, X, Walters, K.J. | Deposit date: | 2018-10-23 | Release date: | 2019-09-04 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Structure of hRpn10 Bound to UBQLN2 UBL Illustrates Basis for Complementarity between Shuttle Factors and Substrates at the Proteasome. J.Mol.Biol., 431, 2019
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7XUQ
| Crystal structure of Tpe3.0 complexed with N-Boc-3-alkenylindole | Descriptor: | Transcriptional regulator, PadR-like family, dimethyl 2-[[2-methyl-1-[(2-methylpropan-2-yl)oxycarbonyl]indol-3-yl]methyl]-2-prop-2-enyl-propanedioate | Authors: | Chen, X, Qian, J.Y, Sun, N.N, Zhong, F.R, Wu, Y.Z. | Deposit date: | 2022-05-19 | Release date: | 2022-09-28 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Enantioselective [2+2]-cycloadditions with triplet photoenzymes. Nature, 611, 2022
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7XUP
| Crystal structure of TPe3.0 | Descriptor: | Transcriptional regulator, PadR-like family | Authors: | Chen, X, Qian, J.Y, Sun, N.N, Zhong, F.R, Wu, Y.Z. | Deposit date: | 2022-05-19 | Release date: | 2022-09-28 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.602 Å) | Cite: | Enantioselective [2+2]-cycloadditions with triplet photoenzymes. Nature, 611, 2022
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6OER
| Cryo-EM structure of mouse RAG1/2 NFC complex (DNA2) | Descriptor: | CALCIUM ION, DNA (46-MER), DNA (57-MER), ... | Authors: | Chen, X, Cui, Y, Zhou, Z.H, Yang, W, Gellert, M. | Deposit date: | 2019-03-27 | Release date: | 2020-01-29 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.29 Å) | Cite: | Cutting antiparallel DNA strands in a single active site. Nat.Struct.Mol.Biol., 27, 2020
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6OEM
| Cryo-EM structure of mouse RAG1/2 PRC complex (DNA0) | Descriptor: | DNA (46-MER), DNA (57-MER), High mobility group protein B1, ... | Authors: | Chen, X, Cui, Y, Zhou, Z.H, Yang, W, Gellert, M. | Deposit date: | 2019-03-27 | Release date: | 2020-01-29 | Last modified: | 2020-02-26 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Cutting antiparallel DNA strands in a single active site. Nat.Struct.Mol.Biol., 27, 2020
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6OEP
| Cryo-EM structure of mouse RAG1/2 12RSS-NFC/23RSS-PRC complex (DNA1) | Descriptor: | CALCIUM ION, DNA (46-MER), DNA (57-MER), ... | Authors: | Chen, X, Cui, Y, Zhou, Z.H, Yang, W, Gellert, M. | Deposit date: | 2019-03-27 | Release date: | 2020-01-29 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Cutting antiparallel DNA strands in a single active site. Nat.Struct.Mol.Biol., 27, 2020
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5W77
| Solution structure of the MYC G-quadruplex bound to small molecule DC-34 | Descriptor: | 4-[(azepan-1-yl)methyl]-5-hydroxy-2-methyl-N-[4-(trifluoromethyl)phenyl]-1-benzofuran-3-carboxamide, DNA (5'-D(*TP*GP*AP*GP*GP*GP*TP*GP*GP*GP*TP*AP*GP*GP*GP*TP*GP*GP*GP*TP*AP*A)-3'), POTASSIUM ION | Authors: | Chen, X, Walters, K.J. | Deposit date: | 2017-06-19 | Release date: | 2018-10-24 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Chemical and structural studies provide a mechanistic basis for recognition of the MYC G-quadruplex. Nat Commun, 9, 2018
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5ZCS
| 4.9 Angstrom Cryo-EM structure of human mTOR complex 2 | Descriptor: | Rapamycin-insensitive companion of mTOR, Serine/threonine-protein kinase mTOR, Target of rapamycin complex 2 subunit MAPKAP1, ... | Authors: | Chen, X, Liu, M, Tian, Y, Wang, H, Wang, J, Xu, Y. | Deposit date: | 2018-02-20 | Release date: | 2018-03-21 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (4.9 Å) | Cite: | Cryo-EM structure of human mTOR complex 2. Cell Res., 28, 2018
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7XPM
| Ancestral ADH WT | Descriptor: | 1,2-ETHANEDIOL, A64 | Authors: | Chen, X.Y, Xu, G.C, Ni, Y. | Deposit date: | 2022-05-04 | Release date: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Crystal structure of a versatile ancestral ADH with high activity and thermostability To Be Published
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5IT2
| Structure of a transglutaminase 2-specific autoantibody 693-10-B06 Fab fragment | Descriptor: | heavy chain, light chain | Authors: | Chen, X, Dalhus, B, Hnida, K, Iversen, R, Sollid, L.M. | Deposit date: | 2016-03-16 | Release date: | 2017-03-22 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | High abundance of plasma cells secreting transglutaminase 2-specific IgA autoantibodies with limited somatic hypermutation in celiac disease intestinal lesions Nat. Med., 18, 2012
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4TYA
| An Ligand-observed Mass Spectrometry-based Approach Integrated into the Fragment Based Lead Discovery Pipeline | Descriptor: | 4-(trifluoromethyl)benzoic acid, Polyprotein | Authors: | Shui, W, Yang, C, Lin, J, Chen, X, Qin, S, Chen, S. | Deposit date: | 2014-07-08 | Release date: | 2015-05-06 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.94 Å) | Cite: | A ligand-observed mass spectrometry approach integrated into the fragment based lead discovery pipeline Sci Rep, 5, 2015
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4TXS
| An Ligand-observed Mass Spectrometry-based Approach Integrated into the Fragment Based Lead Discovery Pipeline | Descriptor: | (4-hydroxyphenyl)acetonitrile, Polyprotein | Authors: | Shui, W, Yang, C, Lin, J, Chen, X, Qin, S, Chen, S. | Deposit date: | 2014-07-07 | Release date: | 2015-05-06 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.78 Å) | Cite: | A ligand-observed mass spectrometry approach integrated into the fragment based lead discovery pipeline Sci Rep, 5, 2015
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4TY8
| An Ligand-observed Mass Spectrometry-based Approach Integrated into the Fragment Based Lead Discovery Pipeline | Descriptor: | 6-methyl-2H-chromen-2-one, Polyprotein | Authors: | Shui, W, Yang, C, Lin, J, Chen, X, Qin, S, Chen, S. | Deposit date: | 2014-07-08 | Release date: | 2015-05-06 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.78 Å) | Cite: | A ligand-observed mass spectrometry approach integrated into the fragment based lead discovery pipeline Sci Rep, 5, 2015
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7QZQ
| Crystal structure of the kelch domain of human KBTBD12 | Descriptor: | 1,2-ETHANEDIOL, Kelch repeat and BTB domain-containing protein 12, SODIUM ION | Authors: | Manning, C.E, Chen, Z, Chen, X, Bradshaw, W.J, Bakshi, S, Mckinley, G, Chalk, R, Burgess-Brown, N, von Delft, F, Bullock, A.N. | Deposit date: | 2022-01-31 | Release date: | 2022-05-04 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Crystal structure of the kelch domain of human KBTBD12 To Be Published
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6VBK
| Crystal structure of N-terminal domain of Mycobacterium tuberculosis complex Lon protease | Descriptor: | GLYCEROL, Lon211 | Authors: | Bi, F.K, Chen, C, Chen, X.Y, Guo, C.Y, Lin, D.H. | Deposit date: | 2019-12-19 | Release date: | 2020-12-23 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of the N domain of Lon protease from Mycobacterium avium complex. Protein Sci., 28, 2019
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4XKL
| Crystal structure of NDP52 ZF2 in complex with mono-ubiquitin | Descriptor: | ACETATE ION, Calcium-binding and coiled-coil domain-containing protein 2, GLYCEROL, ... | Authors: | Xie, X, Li, F, Wang, Y, Lin, Z, Chen, X, Liu, J, Pan, L. | Deposit date: | 2015-01-12 | Release date: | 2015-11-11 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Molecular basis of ubiquitin recognition by the autophagy receptor CALCOCO2 Autophagy, 11, 2015
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8Z1E
| A homotrimeric GPCR architecture of the human cytomegalovirus (UL78) revealed by cryo-EM | Descriptor: | Uncharacterized protein UL78 | Authors: | Chen, Y, Li, Y, Zhou, Q, Cong, Z, Lin, S, Yan, J, Chen, X, Yang, D, Ying, T, Wang, M.-W. | Deposit date: | 2024-04-11 | Release date: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.12 Å) | Cite: | A homotrimeric GPCR architecture of the human cytomegalovirus revealed by cryo-EM To Be Published
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5K83
| Crystal Structure of a Primate APOBEC3G N-Domain, in Complex with ssDNA | Descriptor: | Apolipoprotein B mRNA editing enzyme, catalytic peptide-like 3G,Apolipoprotein B mRNA editing enzyme, catalytic peptide-like 3G, ... | Authors: | Xiao, X, Li, S.-X, Yang, H, Chen, X.S. | Deposit date: | 2016-05-27 | Release date: | 2016-08-10 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.39 Å) | Cite: | Crystal structures of APOBEC3G N-domain alone and its complex with DNA. Nat Commun, 7, 2016
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5K81
| Crystal Structure of a Primate APOBEC3G N-Terminal Domain | Descriptor: | Apolipoprotein B mRNA editing enzyme, catalytic peptide-like 3G,Apolipoprotein B mRNA editing enzyme, catalytic peptide-like 3G, ... | Authors: | Xiao, X, Li, S.-X, Yang, H, Chen, X.S. | Deposit date: | 2016-05-27 | Release date: | 2016-08-10 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.006 Å) | Cite: | Crystal structures of APOBEC3G N-domain alone and its complex with DNA. Nat Commun, 7, 2016
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5K82
| Crystal Structure of a Primate APOBEC3G N-Terminal Domain | Descriptor: | Apolipoprotein B mRNA editing enzyme, catalytic peptide-like 3G,Apolipoprotein B mRNA editing enzyme, catalytic peptide-like 3G, ... | Authors: | Xiao, X, Li, S.-X, Yang, H, Chen, X.S. | Deposit date: | 2016-05-27 | Release date: | 2016-08-10 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.913 Å) | Cite: | Crystal structures of APOBEC3G N-domain alone and its complex with DNA. Nat Commun, 7, 2016
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8CIE
| Crystal structure of the human CDKL5 kinase domain with compound YL-354 | Descriptor: | 4-[[3,5-bis(fluoranyl)phenyl]carbonylamino]-~{N}-piperidin-4-yl-1~{H}-pyrazole-3-carboxamide, Cyclin-dependent kinase-like 5, SULFATE ION | Authors: | Richardson, W, Chen, X, Newman, J.A, Bakshi, S, Lakshminarayana, B, Brooke, L, Bullock, A.N. | Deposit date: | 2023-02-09 | Release date: | 2023-06-14 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective. Acs Chem Neurosci, 14, 2023
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5X07
| Crystal structure of FOXA2 DNA binding domain bound to a full consensus DNA site | Descriptor: | DNA (5'-D(*CP*AP*AP*AP*AP*TP*GP*TP*AP*AP*AP*CP*AP*AP*GP*A)-3'), DNA (5'-D(*TP*CP*TP*TP*GP*TP*TP*TP*AP*CP*AP*TP*TP*TP*TP*G)-3'), Hepatocyte nuclear factor 3-beta | Authors: | Li, J, Guo, M, Zhou, Z, Jiang, L, Chen, X, Qu, L, Wu, D, Chen, Z, Chen, L, Chen, Y. | Deposit date: | 2017-01-20 | Release date: | 2017-08-16 | Last modified: | 2017-09-27 | Method: | X-RAY DIFFRACTION (2.796 Å) | Cite: | Structure of the Forkhead Domain of FOXA2 Bound to a Complete DNA Consensus Site Biochemistry, 56, 2017
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1C9S
| CRYSTAL STRUCTURE OF A COMPLEX OF TRP RNA-BINDING ATTENUATION PROTEIN WITH A 53-BASE SINGLE STRANDED RNA CONTAINING ELEVEN GAG TRIPLETS SEPARATED BY AU DINUCLEOTIDES | Descriptor: | SINGLE STRANDED RNA (55-MER), TRP RNA-BINDING ATTENUATION PROTEIN, TRYPTOPHAN | Authors: | Antson, A.A, Dodson, E.J, Dodson, G.G, Greaves, R.B, Chen, X.-P, Gollnick, P. | Deposit date: | 1999-08-03 | Release date: | 1999-09-15 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure of the trp RNA-binding attenuation protein, TRAP, bound to RNA. Nature, 401, 1999
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6JFK
| GDP bound Mitofusin2 (MFN2) | Descriptor: | CITRIC ACID, GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Li, Y.J, Cao, Y.L, Feng, J.X, Qi, Y.B, Meng, S.X, Yang, J.F, Zhong, Y.T, Kang, S.S, Chen, X.X, Lan, L, Luo, L, Yu, B, Chen, S.D, Chan, D.C, Hu, J.J, Gao, S. | Deposit date: | 2019-02-10 | Release date: | 2019-11-13 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.997 Å) | Cite: | Structural insights of human mitofusin-2 into mitochondrial fusion and CMT2A onset. Nat Commun, 10, 2019
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