5JWY
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![BU of 5jwy by Molmil](/molmil-images/mine/5jwy) | Structure of lipid phosphate phosphatase PgpB complex with PE | Descriptor: | (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradecanoyloxy)propyl tetradecanoate, Phosphatidylglycerophosphatase B | Authors: | Tong, S, Wang, M, Zheng, L. | Deposit date: | 2016-05-12 | Release date: | 2016-07-20 | Last modified: | 2019-11-27 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural Insight into Substrate Selection and Catalysis of Lipid Phosphate Phosphatase PgpB in the Cell Membrane. J.Biol.Chem., 291, 2016
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3EHR
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![BU of 3ehr by Molmil](/molmil-images/mine/3ehr) | Crystal Structure of Human Osteoclast Stimulating Factor | Descriptor: | Osteoclast-stimulating factor 1 | Authors: | Tong, S, Zhou, H, Gao, Y, Zhu, Z, Zhang, X, Teng, M, Niu, L. | Deposit date: | 2008-09-14 | Release date: | 2009-08-04 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Crystal structure of human osteoclast stimulating factor Proteins, 75, 2009
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3EHQ
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![BU of 3ehq by Molmil](/molmil-images/mine/3ehq) | Crystal Structure of Human Osteoclast Stimulating Factor | Descriptor: | 1,2-ETHANEDIOL, Osteoclast-stimulating factor 1 | Authors: | Tong, S, Zhou, H, Gao, Y, Zhu, Z, Zhang, X, Teng, M, Niu, L. | Deposit date: | 2008-09-14 | Release date: | 2009-08-04 | Last modified: | 2021-11-10 | Method: | X-RAY DIFFRACTION (2.57 Å) | Cite: | Crystal structure of human osteoclast stimulating factor Proteins, 75, 2009
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6K1S
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![BU of 6k1s by Molmil](/molmil-images/mine/6k1s) | Discovery of Potent and Selective Covalent Protein Arginine Methyltransferase (PRMT5) Inhibitors | Descriptor: | 1,2-ETHANEDIOL, 2-[[7-[(2~{R},3~{R},4~{S},5~{R})-5-[(~{R})-(4-chlorophenyl)-oxidanyl-methyl]-3,4-bis(oxidanyl)oxolan-2-yl]pyrrolo[2,3-d]pyrimidin-4-yl]amino]ethanal, DIMETHYL SULFOXIDE, ... | Authors: | Tong, S, Lin, H. | Deposit date: | 2019-05-12 | Release date: | 2019-06-19 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Discovery of Potent and Selective Covalent Protein Arginine Methyltransferase 5 (PRMT5) Inhibitors. Acs Med.Chem.Lett., 10, 2019
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6ECH
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![BU of 6ech by Molmil](/molmil-images/mine/6ech) | Pyruvate Kinase Isoform L-type with phosphorylated Ser12 (pS12) in complex with FBP | Descriptor: | 1,2-ETHANEDIOL, 1,6-di-O-phosphono-beta-D-fructofuranose, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Padyana, A, Tong, S. | Deposit date: | 2018-08-07 | Release date: | 2019-12-04 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.19 Å) | Cite: | Distinct Hepatic PKA and CDK Signaling Pathways Control Activity-Independent Pyruvate Kinase Phosphorylation and Hepatic Glucose Production. Cell Rep, 29, 2019
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6ECK
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![BU of 6eck by Molmil](/molmil-images/mine/6eck) | Pyruvate Kinase Isoform L-type with phosphorylated Ser113 (pS113) in complex with FBP | Descriptor: | 1,2-ETHANEDIOL, 1,6-di-O-phosphono-beta-D-fructofuranose, CITRATE ANION, ... | Authors: | Padyana, A, Tong, S. | Deposit date: | 2018-08-08 | Release date: | 2019-12-04 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.36 Å) | Cite: | Distinct Hepatic PKA and CDK Signaling Pathways Control Activity-Independent Pyruvate Kinase Phosphorylation and Hepatic Glucose Production. Cell Rep, 29, 2019
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3B4D
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![BU of 3b4d by Molmil](/molmil-images/mine/3b4d) | Crystal Structure of Human PABPN1 RRM | Descriptor: | Polyadenylate-binding protein 2 | Authors: | Ge, H, Tong, S, Teng, M, Niu, L. | Deposit date: | 2007-10-24 | Release date: | 2008-01-15 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.001 Å) | Cite: | Crystal structure and possible dimerization of the single RRM of human PABPN1 Proteins, 71, 2008
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4KJS
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![BU of 4kjs by Molmil](/molmil-images/mine/4kjs) | Structure of native YfkE | Descriptor: | cation exchanger YfkE | Authors: | Wu, M, Tong, S, Zheng, L. | Deposit date: | 2013-05-03 | Release date: | 2013-06-26 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.05 Å) | Cite: | Crystal structure of Ca2+/H+ antiporter protein YfkE reveals the mechanisms of Ca2+ efflux and its pH regulation. Proc.Natl.Acad.Sci.USA, 110, 2013
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4KJR
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![BU of 4kjr by Molmil](/molmil-images/mine/4kjr) | |
3ELI
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![BU of 3eli by Molmil](/molmil-images/mine/3eli) | Crystal structure of the AHSA1 (SPO3351) protein from Silicibacter pomeroyi, Northeast Structural Genomics Consortium Target SiR160 | Descriptor: | Aha1 domain protein | Authors: | Forouhar, F, Su, M, Seetharaman, J, Janjua, H, Xiao, R, Ciccosanti, C, Foote, E.L, Wang, D, Tong, S, Everett, J.K, Acton, T.B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2008-09-22 | Release date: | 2008-09-30 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structure of the AHSA1 (SPO3351) protein from Silicibacter pomeroyi, Northeast Structural Genomics Consortium Target SiR160 To be Published
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3E23
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![BU of 3e23 by Molmil](/molmil-images/mine/3e23) | Crystal structure of the RPA2492 protein in complex with SAM from Rhodopseudomonas palustris, Northeast Structural Genomics Consortium Target RpR299 | Descriptor: | S-ADENOSYLMETHIONINE, SULFATE ION, uncharacterized protein RPA2492 | Authors: | Forouhar, F, Chen, Y, Seetharaman, J, Mao, L, Xiao, R, Foote, E.L, Ciccosanti, C, Wang, H, Tong, S, Everett, J.K, Acton, T.B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2008-08-05 | Release date: | 2008-09-30 | Last modified: | 2018-01-24 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Crystal structure of the RPA2492 protein in complex with SAM from Rhodopseudomonas palustris, Northeast Structural Genomics Consortium Target RpR299 To be Published
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3DTO
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![BU of 3dto by Molmil](/molmil-images/mine/3dto) | Crystal structure of the metal-dependent HD domain-containing hydrolase BH2835 from Bacillus halodurans, Northeast Structural Genomics Consortium Target BhR130. | Descriptor: | BH2835 protein | Authors: | Forouhar, F, Su, M, Seetharaman, J, Janjua, H, Fang, Y, Xiao, R, Cunningham, K, Ma, L.-C, Owen, L.A, Wang, D, Tong, S, Everett, J.K, Acton, T.B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2008-07-15 | Release date: | 2008-09-09 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Crystal structure of the metal-dependent HD domain-containing hydrolase BH2835 from Bacillus halodurans, Northeast Structural Genomics Consortium Target BhR130. To be Published
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2KZ5
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![BU of 2kz5 by Molmil](/molmil-images/mine/2kz5) | Solution NMR Structure of Transcription factor NF-E2 subunit's DNA binding domain from Homo sapiens, Northeast Structural Genomics Consortium Target HR4653B | Descriptor: | Transcription factor NF-E2 45 kDa subunit | Authors: | Liu, G, Janjua, H, Xiao, R, Ciccosanti, C, Shastry, R, Acton, T.B, Tong, S, Everett, J.K, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2010-06-11 | Release date: | 2010-07-07 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Northeast Structural Genomics Consortium Target HR4653B To be Published
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2L82
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![BU of 2l82 by Molmil](/molmil-images/mine/2l82) | Solution NMR Structure of de novo designed protein, P-loop NTPase fold, Northeast Structural Genomics Consortium Target OR32 | Descriptor: | DESIGNED PROTEIN OR32 | Authors: | Liu, G, Koga, N, Koga, R, Xiao, R, Hamilton, K, Janjua, H, Tong, S, Acton, T.B, Everett, J, Baker, D, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2010-12-31 | Release date: | 2011-02-09 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Northeast Structural Genomics Consortium Target OR32 To be Published
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3P6Y
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![BU of 3p6y by Molmil](/molmil-images/mine/3p6y) | CF Im25-CF Im68-UGUAA complex | Descriptor: | 5'-R(*UP*GP*UP*AP*A)-3', Cleavage and polyadenylation specificity factor subunit 5, Cleavage and polyadenylation specificity factor subunit 6 | Authors: | Li, H, Tong, S, Li, X, Shi, H, Gao, Y, Ge, H, Niu, L, Teng, M. | Deposit date: | 2010-10-11 | Release date: | 2010-11-03 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural basis of pre-mRNA recognition by the human cleavage factor Im complex To be Published
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3P5T
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![BU of 3p5t by Molmil](/molmil-images/mine/3p5t) | CFIm25-CFIm68 complex | Descriptor: | Cleavage and polyadenylation specificity factor subunit 5, Cleavage and polyadenylation specificity factor subunit 6 | Authors: | Li, H, Tong, S, Li, X, Shi, H, Gao, Y, Ge, H, Niu, L, Teng, M. | Deposit date: | 2010-10-11 | Release date: | 2010-11-03 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural basis of pre-mRNA recognition by the human cleavage factor Im complex To be Published
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2L81
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![BU of 2l81 by Molmil](/molmil-images/mine/2l81) | Solution NMR Structure of the serine-rich domain of hEF1 (Enhancer of filamentation 1) from Homo sapiens, Northeast Structural Genomics Consortium Target HR5554A | Descriptor: | Enhancer of filamentation 1 | Authors: | Liu, G, Xiao, R, Huang, Y.J, Patel, D, Ciccosanti, C.T, Acton, T.B, Tong, S, Everett, J.T, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2010-12-31 | Release date: | 2011-02-09 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Northeast Structural Genomics Consortium Target HR5554A To be Published
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2L0B
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![BU of 2l0b by Molmil](/molmil-images/mine/2l0b) | Solution NMR structure of zinc finger domain of E3 ubiquitin-protein ligase praja-1 from Homo sapiens, Northeast Structural Genomics Consortium (NESG) target HR4710B | Descriptor: | E3 ubiquitin-protein ligase Praja-1, ZINC ION | Authors: | Liu, G, Tong, S, Hamilton, K, Ciccosanti, C, Shastry, R, Acton, T.B, Xiao, R, Everett, J.K, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2010-06-30 | Release date: | 2010-08-25 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Solution structure of zinc finger domain of E3 ubiquitin-protein ligase protein praja-1 from Homo sapiens, northeast structural genomics consortium (NESG) target HR4710B To be Published
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4K3X
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![BU of 4k3x by Molmil](/molmil-images/mine/4k3x) | |
4MC7
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![BU of 4mc7 by Molmil](/molmil-images/mine/4mc7) | Crystal structure of a subtype N11 neuraminidase-like protein of A/flat-faced bat/Peru/033/2010 (H18N11) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, NEURAMINIDASE | Authors: | Yang, H, Carney, P.J, Chang, J.C, Guo, Z, Stevens, J. | Deposit date: | 2013-08-21 | Release date: | 2013-10-23 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.99 Å) | Cite: | New world bats harbor diverse influenza a viruses. Plos Pathog., 9, 2013
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4K3Y
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![BU of 4k3y by Molmil](/molmil-images/mine/4k3y) | |
4MC5
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![BU of 4mc5 by Molmil](/molmil-images/mine/4mc5) | Crystal structure of a subtype H18 hemagglutinin homologue from A/flat-faced bat/Peru/033/2010 (H18N11) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ... | Authors: | Yang, H, Carney, P.J, Chang, J.C, Guo, Z, Stevens, J. | Deposit date: | 2013-08-21 | Release date: | 2013-10-23 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.238 Å) | Cite: | New world bats harbor diverse influenza a viruses. Plos Pathog., 9, 2013
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7RW7
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![BU of 7rw7 by Molmil](/molmil-images/mine/7rw7) | Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with SAM and allosteric inhibitor Compound 9 | Descriptor: | (3'R)-2-[(cyclopropylmethyl)amino]-6-(4-methoxyphenyl)-1'-[(1H-pyrazol-5-yl)methyl]-5,6-dihydro-7H-spiro[pyrido[4,3-d]pyrimidine-8,3'-pyrrolidin]-7-one, 1,2-ETHANEDIOL, CHLORIDE ION, ... | Authors: | Jin, L, Padyana, A.K. | Deposit date: | 2021-08-19 | Release date: | 2022-03-23 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.19 Å) | Cite: | Leveraging Structure-Based Drug Design to Identify Next-Generation MAT2A Inhibitors, Including Brain-Penetrant and Peripherally Efficacious Leads. J.Med.Chem., 65, 2022
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7RWH
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![BU of 7rwh by Molmil](/molmil-images/mine/7rwh) | Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with SAM and allosteric inhibitor AGI-41998 | Descriptor: | 1,2-ETHANEDIOL, 8-(4-bromophenyl)-6-(4-methoxyphenyl)-2-[2,2,2-tris(fluoranyl)ethylamino]pyrido[4,3-d]pyrimidin-7-ol, CHLORIDE ION, ... | Authors: | Jin, L, Padyana, A.K. | Deposit date: | 2021-08-19 | Release date: | 2022-03-23 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.17 Å) | Cite: | Leveraging Structure-Based Drug Design to Identify Next-Generation MAT2A Inhibitors, Including Brain-Penetrant and Peripherally Efficacious Leads. J.Med.Chem., 65, 2022
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7RWG
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![BU of 7rwg by Molmil](/molmil-images/mine/7rwg) | "Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with SAM and allosteric inhibitor AGI-43192 | Descriptor: | (8R)-8-(4-chlorophenyl)-6-(2-methyl-2H-indazol-5-yl)-2-[(2,2,2-trifluoroethyl)amino]-5,8-dihydropyrido[4,3-d]pyrimidin-7(6H)-one, 1,2-ETHANEDIOL, CHLORIDE ION, ... | Authors: | Jin, L, Padyana, A.K. | Deposit date: | 2021-08-19 | Release date: | 2022-03-23 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (0.97 Å) | Cite: | Leveraging Structure-Based Drug Design to Identify Next-Generation MAT2A Inhibitors, Including Brain-Penetrant and Peripherally Efficacious Leads. J.Med.Chem., 65, 2022
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