6K1S

Discovery of Potent and Selective Covalent Protein Arginine Methyltransferase (PRMT5) Inhibitors

Summary for 6K1S

• Entry DOI: 10.2210/pdb6k1s/pdb
• Descriptor: Protein arginine N-methyltransferase 5, Methylosome protein 50, 2-[[7-[(2~{R},3~{R},4~{S},5~{R})-5-[(~{R})-(4-chlorophenyl)-oxidanyl-methyl]-3,4-bis(oxidanyl)oxolan-2-yl]pyrrolo[2,3-d]pyrimidin-4-yl]amino]ethanal, ... (6 entities in total)
• Functional Keywords: prmt5, complex, covalent, inhibitor, transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 112557.47

Authors

Tong, S.,Lin, H. (deposition date: 2019-05-12, release date: 2019-06-19, Last modification date: 2023-11-22)

• Primary citation: Lin, H.,Wang, M.,Zhang, Y.W.,Tong, S.,Leal, R.A.,Shetty, R.,Vaddi, K.,Luengo, J.I.; Discovery of Potent and Selective Covalent Protein Arginine Methyltransferase 5 (PRMT5) Inhibitors.; Acs Med.Chem.Lett., 10:1033-1038, 2019; PubMed: 31312404; DOI: 10.1021/acsmedchemlett.9b00074

Experimental method

X-RAY DIFFRACTION (2.6 Å)