5WQK
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5ZLN
| Crystal structure of mouse TLR9 in complex with two DNAs (CpG DNA and TCGCCA DNA) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DNA (5'-D(*AP*GP*GP*CP*GP*TP*TP*TP*TP*T)-3'), ... | Authors: | Ishida, H, Ohto, U, Shimizu, T. | Deposit date: | 2018-03-28 | Release date: | 2018-04-25 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural basis for species-specific activation of mouse Toll-like receptor 9 FEBS Lett., 592, 2018
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7VGR
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7VGS
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4ZLC
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4ZLD
| Crystal structure of human Roquin-2 ROQ domain in complex with Roquin CDE RNA | Descriptor: | GLYCEROL, RNA (5'-R(*UP*AP*AP*CP*UP*UP*CP*UP*GP*UP*GP*AP*AP*GP*UP*UP*G)-3'), Roquin-2 | Authors: | Sakurai, S, Ohto, U, Shimizu, T. | Deposit date: | 2015-05-01 | Release date: | 2015-08-19 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structure of human Roquin-2 and its complex with constitutive-decay element RNA Acta Crystallogr.,Sect.F, 71, 2015
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5AWB
| Crystal structure of human TLR8 in complex with N1-3-aminomethylbenzyl (meta-amine) | Descriptor: | 1-[[3-(aminomethyl)phenyl]methyl]-2-butyl-imidazo[4,5-c]quinolin-4-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Tanji, H, Ohto, U, Shimizu, T. | Deposit date: | 2015-07-03 | Release date: | 2015-09-23 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure-Based Design of Human TLR8-Specific Agonists with Augmented Potency and Adjuvanticity. J.Med.Chem., 58, 2015
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5AWC
| Crystal structure of human TLR8 in complex with MB-564 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-(4-azanylbutyl)-3-pentyl-quinolin-2-amine, ... | Authors: | Tanji, H, Ohto, U, Shimizu, T. | Deposit date: | 2015-07-03 | Release date: | 2016-07-20 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure-based Design of Human TLR8-specific Agonists with Augmented Potency and Adjuvanticity To Be Published
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5AWD
| Crystal structure of human TLR8 in complex with N1-4-aminomethylbenzyl (IMDQ) | Descriptor: | 1-[[4-(aminomethyl)phenyl]methyl]-2-butyl-imidazo[4,5-c]quinolin-4-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Tanji, H, Ohto, U, Shimizu, T. | Deposit date: | 2015-07-03 | Release date: | 2015-09-23 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Structure-Based Design of Human TLR8-Specific Agonists with Augmented Potency and Adjuvanticity. J.Med.Chem., 58, 2015
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5AZ5
| Crystal structure of human TLR8 in complex with MB-343 | Descriptor: | 1-pentyl-4-phenyl-imidazol-2-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Tanji, H, Ohto, U, Shimizu, T. | Deposit date: | 2015-09-27 | Release date: | 2016-10-05 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of human TLR8 in complex with MB-343 To Be Published
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5AWA
| Crystal structure of human TLR8 in complex with MB-568 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-[[3-(aminomethyl)phenyl]methyl]-3-pentyl-quinolin-2-amine, ... | Authors: | Tanji, H, Ohto, U, Shimizu, T. | Deposit date: | 2015-07-03 | Release date: | 2016-07-20 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure-based Design of Human TLR8-specific Agonists with Augmented Potency and Adjuvanticity To Be Published
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7VAF
| Cryo-EM structure of Rat NTCP complexed with YN69202Fab | Descriptor: | Fab heavy chain from antibody IgG clone number YN69202, Fab light chain from antibody IgG clone number YN69202, Sodium/bile acid cotransporter | Authors: | Asami, J, Shimizu, T, Ohto, U. | Deposit date: | 2021-08-29 | Release date: | 2022-05-25 | Last modified: | 2022-07-13 | Method: | ELECTRON MICROSCOPY (3.11 Å) | Cite: | Structure of the bile acid transporter and HBV receptor NTCP. Nature, 606, 2022
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7VAE
| Cryo-EM structure of bovine NTCP complexed with YN69202Fab | Descriptor: | Fab heavy chain from antibody IgG clone number YN69202, Fab light chain from antibody IgG clone number YN69202, Solute carrier family 10 (Sodium/bile acid cotransporter family), ... | Authors: | Asami, J, Shimizu, T, Ohto, U. | Deposit date: | 2021-08-29 | Release date: | 2022-05-25 | Last modified: | 2022-07-13 | Method: | ELECTRON MICROSCOPY (3.55 Å) | Cite: | Structure of the bile acid transporter and HBV receptor NTCP. Nature, 606, 2022
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7VAG
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7VAD
| Cryo-EM structure of human NTCP complexed with YN69202Fab | Descriptor: | Fab heavy chain from antibody IgG clone number YN69202, Fab light chain from antibody IgG clone number YN69202, Sodium/bile acid cotransporter | Authors: | Asami, J, Shimizu, T, Ohto, U. | Deposit date: | 2021-08-29 | Release date: | 2022-05-25 | Last modified: | 2022-07-13 | Method: | ELECTRON MICROSCOPY (3.41 Å) | Cite: | Structure of the bile acid transporter and HBV receptor NTCP. Nature, 606, 2022
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6KYA
| Crystal structure of human TLR8 in complex TH1027 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[5-methylsulfanyl-4-(3,4,5-trimethylphenyl)-1,2,4-triazol-3-yl]propan-1-ol, ... | Authors: | Tanji, H, Sakaniwa, K, Ohto, U, Shimizu, T. | Deposit date: | 2019-09-17 | Release date: | 2020-05-27 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.89 Å) | Cite: | Rationally Designed Small-Molecule Inhibitors Targeting an Unconventional Pocket on the TLR8 Protein-Protein Interface. J.Med.Chem., 63, 2020
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7WSI
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5JK9
| Crystal structure of human IZUMO1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Izumo sperm-egg fusion protein 1 | Authors: | Ohto, U, Ishida, H, Shimizu, T. | Deposit date: | 2016-04-26 | Release date: | 2016-06-22 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure of IZUMO1-JUNO reveals sperm-oocyte recognition during mammalian fertilization Nature, 534, 2016
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5JKC
| Crystal structure of human IZUMO1-JUNO complex (crystal form 1) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Izumo sperm-egg fusion protein 1, ... | Authors: | Ohto, U, Ishida, H, Shimizu, T. | Deposit date: | 2016-04-26 | Release date: | 2016-06-22 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structure of IZUMO1-JUNO reveals sperm-oocyte recognition during mammalian fertilization Nature, 534, 2016
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5JKD
| Crystal structure of human IZUMO1-JUNO complex (crystal form 2) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Izumo sperm-egg fusion protein 1, ... | Authors: | Ohto, U, Ishida, H, Shimizu, T. | Deposit date: | 2016-04-26 | Release date: | 2016-06-22 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structure of IZUMO1-JUNO reveals sperm-oocyte recognition during mammalian fertilization Nature, 534, 2016
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1UHN
| The crystal structure of the calcium binding protein AtCBL2 from Arabidopsis thaliana | Descriptor: | CALCIUM ION, calcineurin B-like protein 2 | Authors: | Nagae, M, Nozawa, A, Koizumi, N, Sano, H, Hashimoto, H, Sato, M, Shimizu, T. | Deposit date: | 2003-07-07 | Release date: | 2003-11-04 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The Crystal Structure of the Novel Calcium-binding Protein AtCBL2 from Arabidopsis thaliana J.Biol.Chem., 278, 2003
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1V9Y
| Crystal Structure of the heme PAS sensor domain of Ec DOS (ferric form) | Descriptor: | Heme pas sensor protein, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Kurokawa, H, Lee, D.S, Watanabe, M, Sagami, I, Mikami, B, Raman, C.S, Shimizu, T. | Deposit date: | 2004-02-04 | Release date: | 2004-05-25 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.32 Å) | Cite: | A redox-controlled molecular switch revealed by the crystal structure of a bacterial heme PAS sensor. J.Biol.Chem., 279, 2004
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1V9Z
| Crystal Structure of the heme PAS sensor domain of Ec DOS (Ferrous Form) | Descriptor: | Heme pas sensor protein, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Kurokawa, H, Lee, D.S, Watanabe, M, Sagami, I, Mikami, B, Raman, C.S, Shimizu, T. | Deposit date: | 2004-02-04 | Release date: | 2004-05-25 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | A redox-controlled molecular switch revealed by the crystal structure of a bacterial heme PAS sensor. J.Biol.Chem., 279, 2004
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1WLF
| Structure of the N-terminal domain of PEX1 AAA-ATPase: Characterization of a putative adaptor-binding domain | Descriptor: | Peroxisome biogenesis factor 1, SULFATE ION | Authors: | Shiozawa, K, Maita, N, Tomii, K, Seto, A, Goda, N, Tochio, H, Akiyama, Y, Shimizu, T, Shirakawa, M, Hiroaki, H. | Deposit date: | 2004-06-25 | Release date: | 2004-09-07 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Structure of the N-terminal Domain of PEX1 AAA-ATPase: CHARACTERIZATION OF A PUTATIVE ADAPTOR-BINDING DOMAIN J.Biol.Chem., 279, 2004
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1WDA
| Crystal structure of human peptidylarginine deiminase type4 (PAD4) in complex with benzoyl-L-arginine amide | Descriptor: | CALCIUM ION, N-[(E)-2-AMINO-1-(3-{[AMINO(IMINO)METHYL]AMINO}PROPYL)-2-HYDROXYVINYL]BENZAMIDE, Protein-arginine deiminase type IV, ... | Authors: | Arita, K, Hashimoto, H, Shimizu, T, Nakashima, K, Yamada, M, Sato, M. | Deposit date: | 2004-05-12 | Release date: | 2004-07-13 | Last modified: | 2021-11-10 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural basis for Ca(2+)-induced activation of human PAD4 Nat.Struct.Mol.Biol., 11, 2004
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