6KYA

Crystal structure of human TLR8 in complex TH1027

Summary for 6KYA

• Entry DOI: 10.2210/pdb6kya/pdb
• Descriptor: Toll-like receptor 8, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: immune system
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 192191.03

Authors

Tanji, H.,Sakaniwa, K.,Ohto, U.,Shimizu, T. (deposition date: 2019-09-17, release date: 2020-05-27, Last modification date: 2023-11-22)

• Primary citation: Jiang, S.,Tanji, H.,Yin, K.,Zhang, S.,Sakaniwa, K.,Huang, J.,Yang, Y.,Li, J.,Ohto, U.,Shimizu, T.,Yin, H.; Rationally Designed Small-Molecule Inhibitors Targeting an Unconventional Pocket on the TLR8 Protein-Protein Interface.; J.Med.Chem., 63:4117-4132, 2020; PubMed: 32233366; DOI: 10.1021/acs.jmedchem.9b02128

Experimental method

X-RAY DIFFRACTION (2.89 Å)