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4HPF
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BU of 4hpf by Molmil
Structure of the human SLO3 gating ring
Descriptor: Potassium channel subfamily U member 1
Authors:Leonetti, M.D, Yuan, P, MacKinnon, R.
Deposit date:2012-10-23
Release date:2012-11-07
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Functional and structural analysis of the human SLO3 pH- and voltage-gated K+ channel.
Proc.Natl.Acad.Sci.USA, 109, 2012
4I9W
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BU of 4i9w by Molmil
Human two pore domain K+ channel TRAAK (K2P4.1) - Fab complex structure
Descriptor: ANTIBODY FAB FRAGMENT HEAVY CHAIN, ANTIBODY FAB FRAGMENT LIGHT CHAIN, CALCIUM ION, ...
Authors:Brohawn, S.G, Mackinnon, R.
Deposit date:2012-12-05
Release date:2013-01-23
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Domain-swapped chain connectivity and gated membrane access in a Fab-mediated crystal of the human TRAAK K+ channel.
Proc.Natl.Acad.Sci.USA, 110, 2013
4JTC
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BU of 4jtc by Molmil
Crystal structure of Kv1.2-2.1 paddle chimera channel in complex with Charybdotoxin in Cs+
Descriptor: (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, CESIUM ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Banerjee, A, Lee, A, Campbell, E, MacKinnon, R.
Deposit date:2013-03-23
Release date:2013-06-12
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Structure of a pore-blocking toxin in complex with a eukaryotic voltage-dependent K(+) channel.
Elife, 2, 2013
4JTD
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BU of 4jtd by Molmil
Crystal structure of Kv1.2-2.1 paddle chimera channel in complex with Lys27Met mutant of Charybdotoxin
Descriptor: (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, POTASSIUM ION, ...
Authors:Banerjee, A, Lee, A, Campbell, E, MacKinnon, R.
Deposit date:2013-03-23
Release date:2013-06-12
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:Structure of a pore-blocking toxin in complex with a eukaryotic voltage-dependent K(+) channel.
Elife, 2, 2013
4KFM
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BU of 4kfm by Molmil
Crystal structure of the G protein-gated inward rectifier K+ channel GIRK2 (Kir3.2) in complex with the beta-gamma G protein subunits
Descriptor: DODECYL-BETA-D-MALTOSIDE, G protein-activated inward rectifier potassium channel 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Whorton, M.R, MacKinnon, R.
Deposit date:2013-04-27
Release date:2013-06-12
Last modified:2013-09-11
Method:X-RAY DIFFRACTION (3.45 Å)
Cite:X-ray structure of the mammalian GIRK2-beta gamma G-protein complex.
Nature, 498, 2013
5U6O
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BU of 5u6o by Molmil
Structure of the human HCN1 hyperpolarization-activated cyclic nucleotide-gated ion channel
Descriptor: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
Authors:Lee, C.-H, MacKinnon, R.
Deposit date:2016-12-08
Release date:2017-01-25
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structures of the Human HCN1 Hyperpolarization-Activated Channel.
Cell, 168, 2017
5U76
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BU of 5u76 by Molmil
Chicken Slo2.2 in a closed conformation vitrified in the presence of 300 mM NaCl
Descriptor: Potassium channel subfamily T member 1
Authors:Hite, R.K, MacKinnon, R.
Deposit date:2016-12-11
Release date:2017-02-08
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.76 Å)
Cite:Structural Titration of Slo2.2, a Na(+)-Dependent K(+) Channel.
Cell, 168, 2017
5TQQ
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BU of 5tqq by Molmil
Cryo-electron microscopy structure of a bovine CLC-K chloride channel, main (class 1) conformation
Descriptor: Chloride channel protein, Monoclonal antibody, Fab fragment, ...
Authors:Park, E, MacKinnon, R.
Deposit date:2016-10-24
Release date:2017-01-04
Last modified:2019-11-20
Method:ELECTRON MICROSCOPY (3.76 Å)
Cite:Structure of a CLC chloride ion channel by cryo-electron microscopy.
Nature, 541, 2017
5U6P
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BU of 5u6p by Molmil
Structure of the human HCN1 hyperpolarization-activated cyclic nucleotide-gated ion channel in complex with cAMP
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 11
Authors:Lee, C.-H, MacKinnon, R.
Deposit date:2016-12-08
Release date:2017-01-25
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.51 Å)
Cite:Structures of the Human HCN1 Hyperpolarization-Activated Channel.
Cell, 168, 2017
5TR1
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BU of 5tr1 by Molmil
Cryo-electron microscopy structure of a bovine CLC-K chloride channel, alternate (class 2) conformation
Descriptor: CHOLESTEROL HEMISUCCINATE, Chloride channel protein, Monoclonal antibody, ...
Authors:Park, E, MacKinnon, R.
Deposit date:2016-10-25
Release date:2017-01-11
Last modified:2019-11-20
Method:ELECTRON MICROSCOPY (3.95 Å)
Cite:Structure of a CLC chloride ion channel by cryo-electron microscopy.
Nature, 541, 2017
5U70
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BU of 5u70 by Molmil
Chicken Slo2.2 in an open conformation vitrified in the presence of 300 mM NaCl
Descriptor: Potassium channel subfamily T member 1
Authors:Hite, R.K, MacKinnon, R.
Deposit date:2016-12-09
Release date:2017-02-08
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.76 Å)
Cite:Structural Titration of Slo2.2, a Na(+)-Dependent K(+) Channel.
Cell, 168, 2017
5VA3
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BU of 5va3 by Molmil
Cryo-EM structure of the human ether-a-go-go related K+ channel
Descriptor: Potassium voltage-gated channel subfamily H member 2
Authors:Wang, W.W, MacKinnon, R.
Deposit date:2017-03-24
Release date:2017-05-03
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Cryo-EM Structure of the Open Human Ether-a-go-go-Related K(+) Channel hERG.
Cell, 169, 2017
5VA1
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BU of 5va1 by Molmil
Cryo-EM structure of the human ether-a-go-go related K+ channel
Descriptor: Potassium voltage-gated channel subfamily H member 2
Authors:Wang, W.W, MacKinnon, R.
Deposit date:2017-03-24
Release date:2017-05-03
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Cryo-EM Structure of the Open Human Ether-a-go-go-Related K(+) Channel hERG.
Cell, 169, 2017
2IH3
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BU of 2ih3 by Molmil
Ion selectivity in a semi-synthetic K+ channel locked in the conductive conformation
Descriptor: (1S)-2-HYDROXY-1-[(NONANOYLOXY)METHYL]ETHYL MYRISTATE, FAB Heavy Chain, FAB Light Chain, ...
Authors:Valiyaveetil, F.I, Leonetti, M, Muir, T.W, MacKinnon, R.
Deposit date:2006-09-25
Release date:2006-11-21
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Ion Selectivity in a Semisynthetic K+ Channel Locked in the Conductive Conformation.
Science, 314, 2006
2ITD
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BU of 2itd by Molmil
Potassium Channel KcsA-Fab complex in Barium Chloride
Descriptor: BARIUM ION, Voltage-gated potassium channel, antibody Fab fragment heavy chain, ...
Authors:Lockless, S.W, Zhou, M, MacKinnon, R.
Deposit date:2006-10-19
Release date:2007-05-15
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural and Thermodynamic Properties of Selective Ion Binding in a K(+) Channel.
Plos Biol., 5, 2007
2ITC
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BU of 2itc by Molmil
Potassium Channel KcsA-Fab complex in Sodium Chloride
Descriptor: Antibody Fab fragment heavy chain, Antibody Fab fragment light chain, SODIUM ION, ...
Authors:Lockless, S.W, Zhou, M, MacKinnon, R.
Deposit date:2006-10-19
Release date:2007-05-15
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural and Thermodynamic Properties of Selective Ion Binding in a K(+) Channel.
Plos Biol., 5, 2007
2IH1
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BU of 2ih1 by Molmil
Ion selectivity in a semi-synthetic K+ channel locked in the conductive conformation
Descriptor: (1S)-2-HYDROXY-1-[(NONANOYLOXY)METHYL]ETHYL MYRISTATE, FAB Heavy Chain, FAB Light Chain, ...
Authors:Valiyaveetil, F.I, Leonetti, M, Muir, T.W, MacKinnon, R.
Deposit date:2006-09-25
Release date:2006-11-21
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Ion Selectivity in a Semisynthetic K+ Channel Locked in the Conductive Conformation.
Science, 314, 2006
2KYH
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BU of 2kyh by Molmil
Solution structure of the voltage-sensing domain of KvAP
Descriptor: Voltage-gated potassium channel
Authors:Butterwick, J.A, MacKinnon, R.
Deposit date:2010-05-26
Release date:2010-09-29
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Solution Structure and Phospholipid Interactions of the Isolated Voltage-Sensor Domain from KvAP.
J.Mol.Biol., 403, 2010
2NLJ
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BU of 2nlj by Molmil
Potassium Channel KcsA(M96V)-Fab complex in KCl
Descriptor: DIACYL GLYCEROL, POTASSIUM ION, Voltage-gated potassium channel, ...
Authors:Lockless, S.W, Zhou, M, MacKinnon, R.
Deposit date:2006-10-20
Release date:2007-05-15
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Structural and Thermodynamic Properties of Selective Ion Binding in a K(+) Channel.
Plos Biol., 5, 2007
3ORG
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BU of 3org by Molmil
Crystal Structure of a eukaryotic CLC transporter
Descriptor: CHLORIDE ION, CmCLC
Authors:Feng, L, MacKinnon, R.
Deposit date:2010-09-07
Release date:2010-10-06
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structure of a eukaryotic CLC transporter defines an intermediate state in the transport cycle.
Science, 330, 2010
1JVM
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BU of 1jvm by Molmil
KCSA POTASSIUM CHANNEL WITH TBA (TETRABUTYLAMMONIUM) AND RUBIDIUM
Descriptor: RUBIDIUM ION, TETRABUTYLAMMONIUM ION, Voltage-gated potassium channel
Authors:Morais-Cabral, J.H, Zhou, Y, MacKinnon, R.
Deposit date:2001-08-30
Release date:2001-12-05
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Energetic optimization of ion conduction rate by the K+ selectivity filter.
Nature, 414, 2001
1K4C
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BU of 1k4c by Molmil
Potassium Channel KcsA-Fab complex in high concentration of K+
Descriptor: DIACYL GLYCEROL, NONAN-1-OL, POTASSIUM ION, ...
Authors:Zhou, Y, Morais-Cabral, J.H, Kaufman, A, MacKinnon, R.
Deposit date:2001-10-07
Release date:2001-11-14
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 A resolution.
Nature, 414, 2001
1K4D
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BU of 1k4d by Molmil
Potassium Channel KcsA-Fab complex in low concentration of K+
Descriptor: DIACYL GLYCEROL, NONAN-1-OL, POTASSIUM ION, ...
Authors:Zhou, Y, Morais-Cabral, J.H, Kaufman, A, MacKinnon, R.
Deposit date:2001-10-07
Release date:2001-11-14
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 A resolution.
Nature, 414, 2001
1N9P
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BU of 1n9p by Molmil
Crystal Structure of the Cytoplasmic Domain of G-protein Activated Inward Rectifier Potassium Channel 1
Descriptor: G protein-activated inward rectifier potassium channel 1
Authors:Nishida, M, MacKinnon, R.
Deposit date:2002-11-26
Release date:2003-01-07
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Basis of Inward Rectification: Cytoplasmic Pore of the G Protein-Gated Inward Rectifier GIRK1 at 1.8 A Resolution
Cell(Cambridge,Mass.), 111, 2002
3SPI
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BU of 3spi by Molmil
Inward rectifier potassium channel Kir2.2 in complex with PIP2
Descriptor: Inward-rectifier K+ channel Kir2.2, POTASSIUM ION, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate
Authors:Hansen, S.B, Tao, X, MacKinnon, R.
Deposit date:2011-07-01
Release date:2011-08-24
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.307 Å)
Cite:Structural basis of PIP(2) activation of the classical inward rectifier K(+) channel Kir2.2.
Nature, 477, 2011

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