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7U6E
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BU of 7u6e by Molmil
Head region of insulin receptor ectodomain (A-isoform) bound to the non-insulin agonist IM462
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, IM462, ...
Authors:Kirk, N.S, Lawrence, M.C.
Deposit date:2022-03-03
Release date:2022-10-05
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Activation of the human insulin receptor by non-insulin-related peptides
Nat Commun, 13, 2022
7U6D
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BU of 7u6d by Molmil
Head region of insulin receptor ectodomain (A-isoform) bound to the non-insulin agonist IM459
Descriptor: IM459, Isoform Short of Insulin receptor
Authors:Kirk, N.S, Lawrence, M.C.
Deposit date:2022-03-03
Release date:2022-10-05
Method:ELECTRON MICROSCOPY (5.03 Å)
Cite:Activation of the human insulin receptor by non-insulin-related peptides
Nat Commun, 13, 2022
8TAN
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BU of 8tan by Molmil
CryoEM structure of MFRV-VILP bound to IGF1Rzip
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin-like growth factor, ...
Authors:Kirk, N.S.
Deposit date:2023-06-27
Release date:2024-01-17
Last modified:2024-01-31
Method:ELECTRON MICROSCOPY (3.05 Å)
Cite:A viral insulin-like peptide inhibits IGF-1 receptor phosphorylation and regulates IGF1R gene expression.
Mol Metab, 80, 2024
7U23
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BU of 7u23 by Molmil
Single-chain LCDV-1 viral insulin-like peptide bound to IGF-1R ectodomain, leucine-zippered form
Descriptor: Insulin-like growth factor 1 receptor, single-chain LCDV-1 viral insulin-like peptide
Authors:Kirk, N.S, Lawrence, M.C.
Deposit date:2022-02-22
Release date:2022-11-16
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:Interaction of a viral insulin-like peptide with the IGF-1 receptor produces a natural antagonist.
Nat Commun, 13, 2022
8UYF
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BU of 8uyf by Molmil
Structure of nucleotide-free Pediculus humanus (Ph) PINK1 dimer
Descriptor: Serine/threonine-protein kinase Pink1, mitochondrial
Authors:Gan, Z.Y, Kirk, N.S, Leis, A, Komander, D.
Deposit date:2023-11-13
Release date:2024-01-31
Method:ELECTRON MICROSCOPY (2.75 Å)
Cite:Interaction of PINK1 with nucleotides and kinetin.
Sci Adv, 10, 2024
8UYI
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BU of 8uyi by Molmil
Structure of ADP-bound and phosphorylated Pediculus humanus (Ph) PINK1 dimer
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Serine/threonine-protein kinase Pink1, ...
Authors:Gan, Z.Y, Kirk, N.S, Leis, A, Komander, D.
Deposit date:2023-11-13
Release date:2024-01-31
Method:ELECTRON MICROSCOPY (3.13 Å)
Cite:Interaction of PINK1 with nucleotides and kinetin.
Sci Adv, 10, 2024
8UYH
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BU of 8uyh by Molmil
Structure of AMP-PNP-bound Pediculus humanus (Ph) PINK1 dimer
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase Pink1, ...
Authors:Gan, Z.Y, Kirk, N.S, Leis, A, Komander, D.
Deposit date:2023-11-13
Release date:2024-01-31
Method:ELECTRON MICROSCOPY (2.84 Å)
Cite:Interaction of PINK1 with nucleotides and kinetin.
Sci Adv, 10, 2024
6VWI
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BU of 6vwi by Molmil
Head region of the closed conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor II.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin-like growth factor II, Leucine-zippered human type 1 insulin-like growth factor receptor ectodomain
Authors:Xu, Y, Kirk, N.S, Lawrence, M.C, Croll, T.I.
Deposit date:2020-02-19
Release date:2020-05-13
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:How IGF-II Binds to the Human Type 1 Insulin-like Growth Factor Receptor.
Structure, 28, 2020
6VWG
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BU of 6vwg by Molmil
Head region of the open conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor II.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin-like growth factor II, Leucine-zippered human type 1 insulin-like growth factor receptor ectodomain
Authors:Xu, Y, Kirk, N.S, Lawrence, M.C, Croll, T.I.
Deposit date:2020-02-19
Release date:2020-05-13
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.21 Å)
Cite:How IGF-II Binds to the Human Type 1 Insulin-like Growth Factor Receptor.
Structure, 28, 2020
6VWJ
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BU of 6vwj by Molmil
Leg region of the closed conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor II
Descriptor: Leucine-zippered human type 1 insulin-like growth factor receptor ectodomain
Authors:Xu, Y, Kirk, N.S, Lawrence, M.C, Croll, T.I.
Deposit date:2020-02-19
Release date:2020-05-13
Last modified:2020-07-22
Method:ELECTRON MICROSCOPY (4.21 Å)
Cite:How IGF-II Binds to the Human Type 1 Insulin-like Growth Factor Receptor.
Structure, 28, 2020
6VWH
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BU of 6vwh by Molmil
Leg region of the open conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor II.
Descriptor: Leucine-zippered human type 1 insulin-like growth factor receptor ectodomain
Authors:Xu, Y, Kirk, N.S, Lawrence, M.C, Croll, T.I.
Deposit date:2020-02-19
Release date:2020-05-13
Last modified:2020-07-22
Method:ELECTRON MICROSCOPY (4.26 Å)
Cite:How IGF-II Binds to the Human Type 1 Insulin-like Growth Factor Receptor.
Structure, 28, 2020
8DI2
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BU of 8di2 by Molmil
Site 2 insulin receptor binding peptide IM459N21
Descriptor: Site 2 binding peptide IM459N21
Authors:Lawrence, M.C, Hu, H, Martinez, F.J, Espinosa, J.F.
Deposit date:2022-06-28
Release date:2022-11-09
Method:SOLUTION NMR
Cite:Activation of the human insulin receptor by non-insulin-related peptides.
Nat Commun, 13, 2022
7S8V
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BU of 7s8v by Molmil
Leg region of a complex of IGF-I with the ectodomain of a hybrid insulin receptor / type 1 insulin-like growth factor receptor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin receptor, ...
Authors:Xu, Y, Lawrence, M.C.
Deposit date:2021-09-20
Release date:2022-07-06
Last modified:2022-08-17
Method:ELECTRON MICROSCOPY (3.73 Å)
Cite:How insulin-like growth factor I binds to a hybrid insulin receptor type 1 insulin-like growth factor receptor.
Structure, 30, 2022
7S0Q
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BU of 7s0q by Molmil
Head region of a complex of IGF-I with the ectodomain of a hybrid insulin receptor / type 1 insulin-like growth factor receptor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin receptor, ...
Authors:Xu, Y, Lawrence, M.C.
Deposit date:2021-08-30
Release date:2022-07-06
Last modified:2022-08-17
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:How insulin-like growth factor I binds to a hybrid insulin receptor type 1 insulin-like growth factor receptor.
Structure, 30, 2022

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