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5NIQ
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BU of 5niq by Molmil
exendin-4 variant with dual GLP-1 / glucagon receptor activity
Descriptor: Exendin-4, N-hexadecanoyl-L-glutamic acid
Authors:Evers, A, Kurz, M.
Deposit date:2017-03-24
Release date:2018-02-28
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Design of Novel Exendin-Based Dual Glucagon-like Peptide 1 (GLP-1)/Glucagon Receptor Agonists.
J.Med.Chem., 60, 2017
6GDZ
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BU of 6gdz by Molmil
exendin-4 based dual GLP-1/glucagon receptor agonist
Descriptor: (2~{S})-2-[[(4~{S})-4-(hexadecanoylamino)-5-oxidanyl-5-oxidanylidene-pentanoyl]amino]pentanedioic acid, Exendin-4
Authors:Evers, A, Kurz, M.
Deposit date:2018-04-25
Release date:2018-06-20
Last modified:2019-05-08
Method:SOLUTION NMR
Cite:Dual Glucagon-like Peptide 1 (GLP-1)/Glucagon Receptor Agonists Specifically Optimized for Multidose Formulations.
J. Med. Chem., 61, 2018
6GE2
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BU of 6ge2 by Molmil
exendin-4 based dual GLP-1/glucagon receptor agonist
Descriptor: (2~{S})-2-[[(4~{S})-4-(hexadecanoylamino)-5-oxidanyl-5-oxidanylidene-pentanoyl]amino]pentanedioic acid, Exendin-4
Authors:Evers, A, Kurz, M.
Deposit date:2018-04-25
Release date:2018-06-20
Last modified:2019-05-08
Method:SOLUTION NMR
Cite:Dual Glucagon-like Peptide 1 (GLP-1)/Glucagon Receptor Agonists Specifically Optimized for Multidose Formulations.
J. Med. Chem., 61, 2018
4UIB
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BU of 4uib by Molmil
Crystal structure of 3p in complex with tafCPB
Descriptor: (2S)-6-AMINO-2-[[(1R)-1-(CYCLOHEXYLMETHYL)-2-OXO-2-[[(2S)-1,7,7-TRIMETHYLNORBORNAN-2-YL]AMINO]ETHYL]ARBAMOYLAMINO]HEXANOIC ACID, ACETATE ION, CARBOXYPEPTIDASE B, ...
Authors:Halland, N, Broenstrup, M, Czech, J, Czechtizky, W, Evers, A, Follmann, M, Kohlmann, M, Schiell, M, Kurz, M, Schreuder, H.A, Kallus, C.
Deposit date:2015-03-27
Release date:2015-06-03
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Novel Small Molecule Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (Tafia) from Natural Product Anabaenopeptin.
J.Med.Chem., 58, 2015
4UIA
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BU of 4uia by Molmil
Crystal structure of 3a in complex with tafCPB
Descriptor: (2S)-6-azanyl-2-[[(2R)-3-cyclohexyl-1-(3-methylbutylamino)-1-oxidanylidene-propan-2-yl]carbamoylamino]hexanoic acid, CARBOXYPEPTIDASE B, ZINC ION
Authors:Halland, N, Broenstrup, M, Czech, J, Czechtizky, W, Evers, A, Follmann, M, Kohlmann, M, Schiell, M, Kurz, M, Schreuder, H.A, Kallus, C.
Deposit date:2015-03-27
Release date:2015-06-03
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Novel Small Molecule Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (Tafia) from Natural Product Anabaenopeptin.
J.Med.Chem., 58, 2015
6GB1
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BU of 6gb1 by Molmil
Crystal structure of the GLP1 receptor ECD with Peptide 11
Descriptor: Glucagon-like peptide 1 receptor, HEXANE-1,6-DIOL, Peptide 11, ...
Authors:Schreuder, H.A, Liesum, A.
Deposit date:2018-04-13
Release date:2018-06-20
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.73 Å)
Cite:Dual Glucagon-like Peptide 1 (GLP-1)/Glucagon Receptor Agonists Specifically Optimized for Multidose Formulations.
J. Med. Chem., 61, 2018
1MUM
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BU of 1mum by Molmil
Structure of the 2-Methylisocitrate Lyase (PrpB) from Escherichia coli
Descriptor: 2-methylisocitrate lyase, MAGNESIUM ION
Authors:Grimm, C, Reuter, K.
Deposit date:2002-09-24
Release date:2003-04-29
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of 2-methylisocitrate lyase (PrpB) from Escherichia coli and modelling of its ligand bound active centre.
J.Mol.Biol., 328, 2003
5LYD
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BU of 5lyd by Molmil
Crystal structure of 1 in complex with tafCPB
Descriptor: (2~{S})-6-azanyl-2-(sulfamoylamino)hexanoic acid, Carboxypeptidase B, ZINC ION
Authors:Schreuder, H, Liesum, A, Loenze, P.
Deposit date:2016-09-27
Release date:2016-10-26
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Sulfamide as Zinc Binding Motif in Small Molecule Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa).
J. Med. Chem., 59, 2016
5LYL
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BU of 5lyl by Molmil
Crystal structure of 1 in complex with tafCPB
Descriptor: (2~{S})-2-[[(2~{S})-1-(1-adamantylamino)-3-cyclohexyl-1-oxidanylidene-propan-2-yl]sulfamoylamino]-6-azanyl-hexanoic acid, Carboxypeptidase B, ZINC ION
Authors:Schreuder, H, Liesum, A, Loenze, P.
Deposit date:2016-09-28
Release date:2016-10-26
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Sulfamide as Zinc Binding Motif in Small Molecule Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa).
J. Med. Chem., 59, 2016
5LYI
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BU of 5lyi by Molmil
Crystal structure of 1 in complex with tafCPB
Descriptor: (2~{S})-6-azanyl-2-[[(2~{S})-3-cyclohexyl-1-oxidanylidene-1-[[(1~{R},2~{S},4~{R})-1,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl]amino]propan-2-yl]sulfamoylamino]hexanoic acid, Carboxypeptidase B, ZINC ION
Authors:Schreuder, H, Liesum, A, Loenze, P.
Deposit date:2016-09-28
Release date:2016-10-26
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Sulfamide as Zinc Binding Motif in Small Molecule Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa).
J. Med. Chem., 59, 2016
5LYF
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BU of 5lyf by Molmil
Crystal structure of 1 in complex with tafCPB
Descriptor: (2~{S})-6-azanyl-2-[[(2~{R})-1-[[(1~{R},2~{S},4~{S})-2-bicyclo[2.2.1]heptanyl]amino]-3-cyclohexyl-1-oxidanylidene-propan-2-yl]carbamoylamino]hexanoic acid, Carboxypeptidase B, ZINC ION
Authors:Schreuder, H, Liesum, A, Loenze, P.
Deposit date:2016-09-28
Release date:2016-10-26
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Sulfamide as Zinc Binding Motif in Small Molecule Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa).
J. Med. Chem., 59, 2016
8F0J
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BU of 8f0j by Molmil
Calcitonin Receptor in complex with Gs and Pramlintide analogue peptide San45
Descriptor: (2S)-2-{[(1R)-1-hydroxyhexadecyl]oxy}-3-{[(1R)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ...
Authors:Cao, J, Sexton, P.M, Wootten, D.L, Belousoff, M.J.
Deposit date:2022-11-03
Release date:2023-08-02
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (2 Å)
Cite:Structural insight into selectivity of amylin and calcitonin receptor agonists.
Nat.Chem.Biol., 20, 2024
8F2B
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BU of 8f2b by Molmil
Amylin 3 Receptor in complex with Gs and Pramlintide analogue peptide San45
Descriptor: (2S)-2-{[(1R)-1-hydroxyhexadecyl]oxy}-3-{[(1R)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ...
Authors:Cao, J, Sexton, P.M, Wootten, D.L, Belousoff, M.J.
Deposit date:2022-11-07
Release date:2023-08-02
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (2 Å)
Cite:Structural insight into selectivity of amylin and calcitonin receptor agonists.
Nat.Chem.Biol., 20, 2024
8F0K
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BU of 8f0k by Molmil
Human Amylin3 Receptor in complex with Gs and Pramlintide analogue peptide San385
Descriptor: (2S)-2-{[(1R)-1-hydroxyhexadecyl]oxy}-3-{[(1R)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ...
Authors:Cao, J, Sexton, P.M, Wootten, D.L.
Deposit date:2022-11-03
Release date:2023-08-02
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (1.9 Å)
Cite:Structural insight into selectivity of amylin and calcitonin receptor agonists.
Nat.Chem.Biol., 20, 2024
8F2A
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BU of 8f2a by Molmil
Human Amylin3 Receptor in complex with Gs and Pramlintide analogue peptide San385 (Cluster 5 conformation)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Calcitonin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Cao, J, Sexton, P.M, Wootten, D.L, Radostin, D.
Deposit date:2022-11-07
Release date:2023-08-02
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (2.2 Å)
Cite:Structural insight into selectivity of amylin and calcitonin receptor agonists.
Nat.Chem.Biol., 20, 2024
6PMP
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BU of 6pmp by Molmil
Crystal structure of a fragment of rat phospholipase Cepsilon EF3-RA1
Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1, CALCIUM ION
Authors:Rugema, N.Y, Lyon, A.M.
Deposit date:2019-07-02
Release date:2020-07-08
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.73 Å)
Cite:Structure of phospholipase C epsilon reveals an integrated RA1 domain and previously unidentified regulatory elements.
Commun Biol, 3, 2020

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PDB entries from 2024-06-12

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