5LYI

Crystal structure of 1 in complex with tafCPB

Summary for 5LYI

Entry DOI	10.2210/pdb5lyi/pdb
Related	5LYL
Descriptor	Carboxypeptidase B, ZINC ION, (2~{S})-6-azanyl-2-[[(2~{S})-3-cyclohexyl-1-oxidanylidene-1-[[(1~{R},2~{S},4~{R})-1,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl]amino]propan-2-yl]sulfamoylamino]hexanoic acid, ... (4 entities in total)
Functional Keywords	tafinized carboxypeptidase b, hydrolase
Biological source	Sus scrofa (Pig)
Cellular location	Secreted : P09955
Total number of polymer chains	1
Total formula weight	35570.92
Authors	Schreuder, H.,Liesum, A.,Loenze, P. (deposition date: 2016-09-28, release date: 2016-10-26, Last modification date: 2016-12-21)
Primary citation	Halland, N.,Czech, J.,Czechtizky, W.,Evers, A.,Follmann, M.,Kohlmann, M.,Schreuder, H.A.,Kallus, C. Sulfamide as Zinc Binding Motif in Small Molecule Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa). J. Med. Chem., 59:9567-9573, 2016 Cited by PubMed: 27749053 DOI: 10.1021/acs.jmedchem.6b01276 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.64 Å)

Structure validation