8CT6
 
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7UYI
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7JMS
 | | Structure of the Hazara virus OTU bound to ubiquitin | | Descriptor: | CALCIUM ION, GLYCEROL, Polyubiquitin-B, ... | | Authors: | Dzimianski, J.V, Pegan, S.D. | | Deposit date: | 2020-08-02 | | Release date: | 2020-10-21 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.78 Å) | | Cite: | Flipping the substrate preference of Hazara virus ovarian tumour domain protease through structure-based mutagenesis.
Acta Crystallogr D Struct Biol, 76, 2020
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6DWX
 | | Crystal structure of SeMet phased viral OTU domain protease from Qalyub virus | | Descriptor: | RNA-dependent RNA polymerase | | Authors: | Dzimianski, J.V, Beldon, B.S, Daczkowski, C.M, Goodwin, O.Y, Pegan, S.D. | | Deposit date: | 2018-06-28 | | Release date: | 2018-12-19 | | Last modified: | 2019-12-18 | | Method: | X-RAY DIFFRACTION (2.395 Å) | | Cite: | Probing the impact of nairovirus genomic diversity on viral ovarian tumor domain protease (vOTU) structure and deubiquitinase activity.
PLoS Pathog., 15, 2019
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6DX1
 | | Crystal structure of the viral OTU domain protease from Qalyub virus | | Descriptor: | RNA-dependent RNA polymerase | | Authors: | Dzimianski, J.V, Beldon, B.S, Daczkowski, C.M, Goodwin, O.Y, Pegan, S.D. | | Deposit date: | 2018-06-28 | | Release date: | 2018-12-19 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.652 Å) | | Cite: | Probing the impact of nairovirus genomic diversity on viral ovarian tumor domain protease (vOTU) structure and deubiquitinase activity.
PLoS Pathog., 15, 2019
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6DX3
 | | Crystal structure of the viral OTU domain protease from Taggert virus | | Descriptor: | MAGNESIUM ION, RNA-dependent RNA polymerase | | Authors: | Dzimianski, J.V, Beldon, B.S, Daczkowski, C.M, Goodwin, O.Y, Pegan, S.D. | | Deposit date: | 2018-06-28 | | Release date: | 2018-12-19 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.052 Å) | | Cite: | Probing the impact of nairovirus genomic diversity on viral ovarian tumor domain protease (vOTU) structure and deubiquitinase activity.
PLoS Pathog., 15, 2019
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6OAR
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6OAT
 | | Structure of the Ganjam virus OTU bound to sheep ISG15 | | Descriptor: | Interferon stimulated gene 17, RNA-dependent RNA polymerase, prop-2-en-1-amine | | Authors: | Dzimianski, J.V, Williams, I.L, Pegan, S.D. | | Deposit date: | 2019-03-18 | | Release date: | 2020-01-08 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (3.17 Å) | | Cite: | Determining the molecular drivers of species-specific interferon-stimulated gene product 15 interactions with nairovirus ovarian tumor domain proteases.
Plos One, 14, 2019
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5TL6
 | | Crystal structure of SARS-CoV papain-like protease in complex with the C-terminal domain of human ISG15 | | Descriptor: | Replicase polyprotein 1ab, SULFATE ION, Ubiquitin-like protein ISG15, ... | | Authors: | Dzimianski, J.V, Daczkowski, C.M, Pegan, S.D. | | Deposit date: | 2016-10-10 | | Release date: | 2017-05-03 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.618 Å) | | Cite: | Structural Insights into the Interaction of Coronavirus Papain-Like Proteases and Interferon-Stimulated Gene Product 15 from Different Species.
J. Mol. Biol., 429, 2017
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8SJ9
 | | Crystal structure of the H1 hemagglutinin COBRA X6 | | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Dzimianski, J.V, DuBois, R.M. | | Deposit date: | 2023-04-17 | | Release date: | 2024-05-01 | | Last modified: | 2024-06-05 | | Method: | X-RAY DIFFRACTION (3.25 Å) | | Cite: | Structural basis for the broad antigenicity of the computationally optimized influenza hemagglutinin X6.
Structure, 2024
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6DX2
 | | Crystal structure of the viral OTU domain protease from Dera Ghazi Khan virus | | Descriptor: | RNA-dependent RNA polymerase | | Authors: | Beldon, B.S, Dzimianski, J.V, Daczkowski, C.M, Goodwin, O.Y, Pegan, S.D. | | Deposit date: | 2018-06-28 | | Release date: | 2018-12-19 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.614 Å) | | Cite: | Probing the impact of nairovirus genomic diversity on viral ovarian tumor domain protease (vOTU) structure and deubiquitinase activity.
PLoS Pathog., 15, 2019
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6DX5
 | | Crystal structure of the viral OTU domain protease from Farallon virus | | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, RNA-dependent RNA polymerase | | Authors: | Beldon, B.S, Dzimianski, J.V, Daczkowski, C.M, Goodwin, O.Y, Pegan, S.D. | | Deposit date: | 2018-06-28 | | Release date: | 2018-12-19 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.224 Å) | | Cite: | Probing the impact of nairovirus genomic diversity on viral ovarian tumor domain protease (vOTU) structure and deubiquitinase activity.
PLoS Pathog., 15, 2019
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5JZE
 | | Erve virus viral OTU domain protease in complex with mouse ISG15 | | Descriptor: | CITRATE ANION, RNA-dependent RNA polymerase, Ubiquitin-like protein ISG15, ... | | Authors: | Deaton, M.K, Dzimianski, J.V, Pegan, S.D. | | Deposit date: | 2016-05-16 | | Release date: | 2016-10-19 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.47 Å) | | Cite: | Biochemical and Structural Insights into the Preference of Nairoviral DeISGylases for Interferon-Stimulated Gene Product 15 Originating from Certain Species.
J.Virol., 90, 2016
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7MC9
 | | X-RAY STRUCTURE OF PEDV PAPAIN-LIKE PROTEASE 2 bound to UB-PA | | Descriptor: | 3C-like proteinase, Ubiquitin, ZINC ION, ... | | Authors: | Durie, I.A, Dzimianski, J.V, Daczkowski, C.M, Pegan, S.D. | | Deposit date: | 2021-04-01 | | Release date: | 2021-07-07 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (3.099 Å) | | Cite: | Structural insights into the interaction of papain-like protease 2 from the alphacoronavirus porcine epidemic diarrhea virus and ubiquitin
Acta Cryst. D, 77, 2021
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5TLA
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6MDH
 | | X-ray crystal structure of ISG15 from Myotis davidii | | Descriptor: | Ubiquitin-like protein ISG15 | | Authors: | Goodwin, O.Y, Langley, C.A, Dzimianski, J.V, Daczkowski, C.M, Pegan, S.D. | | Deposit date: | 2018-09-04 | | Release date: | 2018-12-12 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.37 Å) | | Cite: | Structure of interferon-stimulated gene product 15 (ISG15) from the bat species Myotis davidii and the impact of interdomain ISG15 interactions on viral protein engagement.
Acta Crystallogr D Struct Biol, 75, 2019
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5W8T
 | | Crystal structure of MERS-CoV papain-like protease in complex with the C-terminal domain of human ISG15 | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, ORF1ab, Ubiquitin-like protein ISG15, ... | | Authors: | Daczkowski, C.M, Goodwin, O.Y, Dzimianski, J.V, Farhat, J.J, Pegan, S.D. | | Deposit date: | 2017-06-22 | | Release date: | 2017-09-27 | | Last modified: | 2024-04-24 | | Method: | X-RAY DIFFRACTION (2.758 Å) | | Cite: | Structurally Guided Removal of DeISGylase Biochemical Activity from Papain-Like Protease Originating from Middle East Respiratory Syndrome Coronavirus.
J. Virol., 91, 2017
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5TL7
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8V7O
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5W8U
 | | Crystal structure of MERS-CoV papain-like protease in complex with the C-terminal domain of human ISG15 | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, ORF1ab, Ubiquitin-like protein ISG15, ... | | Authors: | Daczkowski, C.M, Goodwin, O.Y, Dzimianski, J.D, Pegan, S.D. | | Deposit date: | 2017-06-22 | | Release date: | 2017-09-27 | | Last modified: | 2024-04-24 | | Method: | X-RAY DIFFRACTION (2.411 Å) | | Cite: | Structurally Guided Removal of DeISGylase Biochemical Activity from Papain-Like Protease Originating from Middle East Respiratory Syndrome Coronavirus.
J. Virol., 91, 2017
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