Search by PDB author

PORCINE PANCREATIC ELASTASE COMPLEXED WITH (3S, 4S)N-PARA- TOLUENESULPHONYL-3-ETHYL-4-(CARBOXYLIC ACID) PYRROLIDIN-2-ONE SOAKED IN PH 9 BUFFER FOR ONE MINUTE
Descriptor:	(2S,3S)-3-FORMYL-2-({[(4-METHYLPHENYL)SULFONYL]AMINO}METHYL)PENTANOIC ACID, CALCIUM ION, ELASTASE, ...
Authors:	Wright, P.A, Wilmouth, R.C, Clifton, I.J, Schofield, C.J.
Deposit date:	2000-06-06
Release date:	2000-10-18
Last modified:	2023-12-06
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	`Ph-Jump' Crystallographic Analyses of Gamma-Lactam-Porcine Pancreatic Elastase Complexes Biochem.J., 351, 2000

5OX6

HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with Vadadustat
Descriptor:	Egl nine homolog 1, GLYCEROL, MANGANESE (II) ION, ...
Authors:	Chowdhury, R, Zhang, D, Schofield, C.J.
Deposit date:	2017-09-06
Release date:	2017-10-18
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (1.99 Å)
Cite:	Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials. Chem Sci, 8, 2017

5OX5

HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with CCT6, a GSK1278863-related compound
Descriptor:	(6-hydroxy-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonyl)glycine, BICARBONATE ION, Egl nine homolog 1, ...
Authors:	Chowdhury, R, Thinnes, C.C, Schofield, C.J.
Deposit date:	2017-09-06
Release date:	2017-10-18
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (2.251 Å)
Cite:	Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials. Chem Sci, 8, 2017

6YVT

HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with MD-253
Descriptor:	2-[[5-(6-methoxynaphthalen-2-yl)-3-oxidanyl-pyridin-2-yl]carbonylamino]ethanoic acid, Egl nine homolog 1, GLYCEROL, ...
Authors:	Chowdhury, R, Demetriades, M, Schofield, C.J.
Deposit date:	2020-04-28
Release date:	2020-05-20
Last modified:	2024-01-24
Method:	X-RAY DIFFRACTION (2.847 Å)
Cite:	Dynamic combinatorial chemistry employing boronic acids/boronate esters leads to potent oxygenase inhibitors. Angew.Chem.Int.Ed.Engl., 51, 2012

6I7R

Structure of pVHL-elongin B-elongin C (VCB) in complex with hydroxylated-HIF-2alpha (523-542) in the P43212 form
Descriptor:	Elongin-B, Elongin-C, Endothelial PAS domain-containing protein 1, ...
Authors:	Chowdhury, R, Aguilera, L.S, Schofield, C.J.
Deposit date:	2018-11-17
Release date:	2019-11-27
Last modified:	2024-01-24
Method:	X-RAY DIFFRACTION (1.949 Å)
Cite:	HIF-2alpha-pVHL-elongin B-elongin C complex To Be Published

6I7Q

Structure of pVHL-elongin B-elongin C (VCB) in complex with hydroxylated-HIF-2alpha (523-542) in the C2221 form
Descriptor:	Elongin-B, Elongin-C, Endothelial PAS domain-containing protein 1, ...
Authors:	Chowdhury, R, Aguilera, L.S, Schofield, C.J.
Deposit date:	2018-11-17
Release date:	2019-11-27
Last modified:	2024-01-24
Method:	X-RAY DIFFRACTION (1.798 Å)
Cite:	HIF-2alpha-pVHL-elongin B-elongin C complex To Be Published

5L9V

HIF prolyl hydroxylase 2 (PHD2-R281C/P317C) cross-linked to HIF-1alpha NODD-L397C/D412C and N-oxalylglycine (NOG) (complex-1)
Descriptor:	Egl nine homolog 1, Hypoxia-inducible factor 1-alpha, MANGANESE (II) ION, ...
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2016-06-11
Release date:	2016-08-31
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (1.829 Å)
Cite:	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

5LAS

HIF prolyl hydroxylase 2 (PHD2-R281C/P317C/R396T) cross-linked to HIF-1alpha NODD-L397C/D412C and N-oxalylglycine (NOG) (complex-3)
Descriptor:	Egl nine homolog 1, Hypoxia-inducible factor 1-alpha, MANGANESE (II) ION, ...
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2016-06-14
Release date:	2016-08-31
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

5LB6

HIF prolyl hydroxylase 2 (PHD2/EGLN1) R371H variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/UN9)
Descriptor:	Egl nine homolog 1, GLYCEROL, MANGANESE (II) ION, ...
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2016-06-15
Release date:	2016-08-31
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (1.7 Å)
Cite:	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

5LBE

HIF prolyl hydroxylase 2 (PHD2/EGLN1) G294E variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/FG2216)
Descriptor:	BICARBONATE ION, Egl nine homolog 1, MANGANESE (II) ION, ...
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2016-06-15
Release date:	2016-08-31
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (1.749 Å)
Cite:	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

5LBC

HIF prolyl hydroxylase 2 (PHD2/EGLN1) I280V/R281L/I292V variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/FG2216)
Descriptor:	BICARBONATE ION, CHLORIDE ION, Egl nine homolog 1, ...
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2016-06-15
Release date:	2016-08-31
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (1.816 Å)
Cite:	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

5LBB

HIF prolyl hydroxylase 2 (PHD2/EGLN1) R396T variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/UN9)
Descriptor:	BICARBONATE ION, Egl nine homolog 1, MANGANESE (II) ION, ...
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2016-06-15
Release date:	2016-08-31
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (1.7 Å)
Cite:	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

5L9R

HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with N-oxalylglycine (NOG)
Descriptor:	Egl nine homolog 1, GLYCEROL, MANGANESE (II) ION, ...
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2016-06-10
Release date:	2016-08-31
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (1.81 Å)
Cite:	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

5L9B

HIF PROLYL HYDROXYLASE 2 (PHD2/ EGLN1) IN COMPLEX WITH 2-OXOGLUTARATE (2OG) AND HIF-1ALPHA CODD (556-574)
Descriptor:	2-OXOGLUTARIC ACID, Egl nine homolog 1, Hypoxia-inducible factor 1-alpha, ...
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2016-06-10
Release date:	2016-08-31
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

5LBF

HIF prolyl hydroxylase 2 (PHD2/EGLN1) K293K/G294E variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/FG2216)
Descriptor:	BICARBONATE ION, Egl nine homolog 1, MANGANESE (II) ION, ...
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2016-06-16
Release date:	2016-08-31
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (1.8995 Å)
Cite:	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

5LA9

HIF prolyl hydroxylase 2 (PHD2-R281C/V314C) cross-linked to HIF-1alpha NODD-L397C/D412C and N-oxalylglycine (NOG) (complex-2)
Descriptor:	Egl nine homolog 1, Hypoxia-inducible factor 1-alpha, MANGANESE (II) ION, ...
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2016-06-14
Release date:	2016-08-31
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (2.813 Å)
Cite:	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

5LAT

HIF prolyl hydroxylase 2 (PHD2/EGLN1) P317R variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/UN9)
Descriptor:	BICARBONATE ION, Egl nine homolog 1, GLYCEROL, ...
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2016-06-15
Release date:	2016-08-31
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

5LS3

Crystal structure of metallo-beta-lactamase SPM-1 with Y58C mutation
Descriptor:	Beta-lactamase IMP-1, ZINC ION
Authors:	Hinchliffe, P, Spencer, J.
Deposit date:	2016-08-22
Release date:	2017-03-15
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (1.754 Å)
Cite:	(19) F-NMR Reveals the Role of Mobile Loops in Product and Inhibitor Binding by the Sao Paulo Metallo-beta-Lactamase. Angew. Chem. Int. Ed. Engl., 56, 2017

6YW1

HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with 2OG and RaPID-derived silent allosteric cyclic peptide 3C (14-mer)
Descriptor:	2-OXOGLUTARIC ACID, BICARBONATE ION, Egl nine homolog 1, ...
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2020-04-29
Release date:	2020-12-30
Last modified:	2024-01-24
Method:	X-RAY DIFFRACTION (1.46 Å)
Cite:	Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2. Sci Rep, 10, 2020

6YW2

HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with bicyclic FG2216 and RaPID-derived cyclic peptide 3C (14-mer)
Descriptor:	Egl nine homolog 1, MANGANESE (II) ION, N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE, ...
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2020-04-29
Release date:	2020-12-30
Last modified:	2024-01-24
Method:	X-RAY DIFFRACTION (2.14 Å)
Cite:	Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2. Sci Rep, 10, 2020

6YW3

HIF PROLYL HYDROXYLASE 2 (PHD2/ EGLN1) in complex with N-Oxalyl Glycine (NOG), HIF-1ALPHA CODD (556-574) and a RaPID-derived cyclic peptide 3C (14-mer)
Descriptor:	Egl nine homolog 1, GLYCEROL, Hypoxia-inducible factor 1-alpha, ...
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2020-04-29
Release date:	2020-12-30
Last modified:	2024-01-24
Method:	X-RAY DIFFRACTION (2.279 Å)
Cite:	Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2. Sci Rep, 10, 2020

6YW4

HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with N-oxalylglycine (NOG) and a RaPID-derived silent allosteric cyclic peptide 3C (14-mer)
Descriptor:	Egl nine homolog 1, MANGANESE (II) ION, N-OXALYLGLYCINE, ...
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2020-04-29
Release date:	2020-12-30
Last modified:	2024-01-24
Method:	X-RAY DIFFRACTION (1.528 Å)
Cite:	Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2. Sci Rep, 10, 2020

<12

Total results:	47
Displayed results:	22
Sorted by:	Hit score (from highest)