7NM2
| Solution structure of MLKL executioner domain in complex with a fragment | Descriptor: | 2-[(~{S})-methoxy-(4-propan-2-ylphenyl)methyl]-3~{H}-benzimidazole-5-carboxylic acid, Mixed lineage kinase domain-like protein | Authors: | Ruebbelke, M, Bauer, M, Hamilton, J, Binder, F, Nar, H, Zeeb, M. | Deposit date: | 2021-02-23 | Release date: | 2021-09-22 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Discovery and Structure-Based Optimization of Fragments Binding the Mixed Lineage Kinase Domain-like Protein Executioner Domain. J.Med.Chem., 64, 2021
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7NM4
| Solution structure of MLKL executioner domain in complex with a fragment | Descriptor: | (~{S})-1~{H}-benzimidazol-2-yl-(4-propan-2-ylphenyl)methanol, Mixed lineage kinase domain-like protein | Authors: | Ruebbelke, M, Bauer, M, Hamilton, J, Binder, F, Nar, H, Zeeb, M. | Deposit date: | 2021-02-23 | Release date: | 2021-09-22 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Discovery and Structure-Based Optimization of Fragments Binding the Mixed Lineage Kinase Domain-like Protein Executioner Domain. J.Med.Chem., 64, 2021
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7NM5
| Solution structure of MLKL executioner domain in complex with a fragment | Descriptor: | 2-[(~{S})-methoxy-(4-phenylphenyl)methyl]-3~{H}-benzimidazole-5-carboxylic acid, Mixed lineage kinase domain-like protein | Authors: | Ruebbelke, M, Bauer, M, Hamilton, J, Binder, F, Nar, H, Zeeb, M. | Deposit date: | 2021-02-23 | Release date: | 2021-09-22 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Discovery and Structure-Based Optimization of Fragments Binding the Mixed Lineage Kinase Domain-like Protein Executioner Domain. J.Med.Chem., 64, 2021
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6ZPR
| Solution structure of MLKL executioner domain in complex with a covalent inhibitor | Descriptor: | 7-(2-methoxyethoxymethyl)-1,3-dimethyl-purine-2,6-dione, Mixed lineage kinase domain-like protein,Mixed lineage kinase domain-like protein | Authors: | Ruebbelke, M, Bauer, M, Hamilton, J, Binder, F, Nar, H, Zeeb, M. | Deposit date: | 2020-07-09 | Release date: | 2020-12-16 | Last modified: | 2021-01-06 | Method: | SOLUTION NMR | Cite: | Locking mixed-lineage kinase domain-like protein in its auto-inhibited state prevents necroptosis. Proc.Natl.Acad.Sci.USA, 117, 2020
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6H8R
| CRYSTAL STRUCTURE OF THE HUMAN PROTEIN TYROSINE PHOSPHATASE PTPN5 (STEP) IN COMPLEX WITH COMPOUND 2 | Descriptor: | 3-[(2~{S})-2-azanylpropyl]-5-(trifluoromethyl)phenol, SULFATE ION, Tyrosine-protein phosphatase non-receptor type 5 | Authors: | Hoerer, S, Fiegen, D, Schnapp, G. | Deposit date: | 2018-08-03 | Release date: | 2018-09-26 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.66 Å) | Cite: | Allosteric Activation of Striatal-Enriched Protein Tyrosine Phosphatase (STEP, PTPN5) by a Fragment-like Molecule. J. Med. Chem., 62, 2019
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6H8S
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6ZLE
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6ZVO
| Crystal structure of unliganded MLKL executioner domain | Descriptor: | BROMIDE ION, CHLORIDE ION, Mixed lineage kinase domain-like protein | Authors: | Fiegen, D, Bauer, M, Nar, H. | Deposit date: | 2020-07-27 | Release date: | 2020-12-23 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.371 Å) | Cite: | Locking mixed-lineage kinase domain-like protein in its auto-inhibited state prevents necroptosis. Proc.Natl.Acad.Sci.USA, 117, 2020
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6ZZ1
| Crystal structure of MLKL executioner domain in complex with a covalent inhibitor | Descriptor: | 7-(2-methoxyethoxymethyl)-1,3-dimethyl-purine-2,6-dione, Mixed lineage kinase domain-like protein | Authors: | Fiegen, D, Bauer, M, Nar, H. | Deposit date: | 2020-08-03 | Release date: | 2020-12-23 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.64 Å) | Cite: | Locking mixed-lineage kinase domain-like protein in its auto-inhibited state prevents necroptosis. Proc.Natl.Acad.Sci.USA, 117, 2020
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