4Q4I
 
 | | Crystal structure of E.coli aminopeptidase N in complex with amastatin | | Descriptor: | Amastatin, Aminopeptidase N, GLYCEROL, ... | | Authors: | Reddi, R, Ganji, R.J, Addlagatta, A. | | Deposit date: | 2014-04-14 | | Release date: | 2015-04-15 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.31 Å) | | Cite: | Structural basis for the inhibition of M1 family aminopeptidases by the natural product actinonin: Crystal structure in complex with E. coli aminopeptidase N.
Protein Sci., 24, 2015
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6K26
 | | Crystal structure of Vibrio cholerae methionine aminopeptidase | | Descriptor: | Methionine aminopeptidase, SODIUM ION | | Authors: | Pillalamarri, V, Addlagatta, A. | | Deposit date: | 2019-05-13 | | Release date: | 2020-05-20 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Methionine aminopeptidases with short sequence inserts within the catalytic domain are differentially inhibited: Structural and biochemical studies of three proteins from Vibrio spp.
Eur.J.Med.Chem., 209, 2020
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6KSG
 | | Vibrio cholerae Methionine Aminopeptidase in holo form | | Descriptor: | GLYCEROL, Methionine aminopeptidase, NICKEL (II) ION, ... | | Authors: | Pillalamarri, V, Addlagatta, A. | | Deposit date: | 2019-08-23 | | Release date: | 2020-08-26 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Methionine aminopeptidases with short sequence inserts within the catalytic domain are differentially inhibited: Structural and biochemical studies of three proteins from Vibrio spp.
Eur.J.Med.Chem., 209, 2020
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6LH7
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6LZB
 | | crystal structure of Human Methionine aminopeptidase (HsMetAP1b) in complex with AN-P2-5H-06 | | Descriptor: | 1-[(3-methoxyphenyl)methyl]-~{N}-oxidanyl-pyrrolo[2,3-b]pyridine-5-carboxamide, COBALT (II) ION, GLYCEROL, ... | | Authors: | sandeep, C.B, Addlagatta, A. | | Deposit date: | 2020-02-18 | | Release date: | 2021-02-24 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.29 Å) | | Cite: | Selective inhibition of Helicobacter pylori methionine aminopeptidase by azaindole hydroxamic acid derivatives: Design, synthesis, in vitro biochemical and structural studies.
Bioorg.Chem., 115, 2021
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6LZC
 | | crystal structure of Human Methionine aminopeptidase (HsMetAP1b) in complex with KV-P2-4H-05 | | Descriptor: | COBALT (II) ION, GLYCEROL, MAGNESIUM ION, ... | | Authors: | Sandeep, C.B, Addlagatta, A. | | Deposit date: | 2020-02-18 | | Release date: | 2021-02-24 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.35 Å) | | Cite: | Selective inhibition of Helicobacter pylori methionine aminopeptidase by azaindole hydroxamic acid derivatives: Design, synthesis, in vitro biochemical and structural studies.
Bioorg.Chem., 115, 2021
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3ROR
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6M00
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4U6W
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4U71
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4U75
 | | HsMetAP (F309M) in complex with Methionine | | Descriptor: | COBALT (II) ION, GLYCEROL, METHIONINE, ... | | Authors: | Arya, T, Addlagatta, A. | | Deposit date: | 2014-07-30 | | Release date: | 2015-03-25 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.94 Å) | | Cite: | Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases
J.Med.Chem., 58, 2015
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4U6E
 | | HsMetAP in complex with (amino(phenyl)methyl)phosphonic acid | | Descriptor: | COBALT (II) ION, Methionine aminopeptidase 1, [(R)-amino(phenyl)methyl]phosphonic acid | | Authors: | Arya, T, Addlagatta, A. | | Deposit date: | 2014-07-28 | | Release date: | 2015-03-25 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases
J.Med.Chem., 58, 2015
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4U6Z
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4U1B
 | | HsMetAP in complex with (1-amino-2-propylpentyl)phosphonic acid | | Descriptor: | COBALT (II) ION, GLYCEROL, Methionine aminopeptidase 1, ... | | Authors: | Arya, T, Addlagatta, A. | | Deposit date: | 2014-07-15 | | Release date: | 2015-03-25 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.89 Å) | | Cite: | Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases
J.Med.Chem., 58, 2015
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4U6J
 | | HsMetAP in complex with methionine | | Descriptor: | COBALT (II) ION, GLYCEROL, METHIONINE, ... | | Authors: | Arya, T, Addlagatta, A. | | Deposit date: | 2014-07-29 | | Release date: | 2015-03-25 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.56 Å) | | Cite: | Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases
J.Med.Chem., 58, 2015
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4U69
 | | HsMetAP complex with (1-amino-2-methylpentyl)phosphonic acid | | Descriptor: | COBALT (II) ION, Methionine aminopeptidase 1, POTASSIUM ION, ... | | Authors: | Arya, T, Addlagatta, A. | | Deposit date: | 2014-07-28 | | Release date: | 2015-03-25 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases
J.Med.Chem., 58, 2015
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4U70
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4U76
 | | HsMetAP (F309M) holo form | | Descriptor: | COBALT (II) ION, GLYCEROL, Methionine aminopeptidase 1, ... | | Authors: | Arya, T, Addlagatta, A. | | Deposit date: | 2014-07-30 | | Release date: | 2015-03-25 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.87 Å) | | Cite: | Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases
J.Med.Chem., 58, 2015
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4U6C
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4U73
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4IEC
 | | Cys105 covalent modification by 2-hydroxyethyl disulfide in Mycobacterium tuberculosis methionine aminopeptidase Type 1c | | Descriptor: | COBALT (II) ION, Methionine aminopeptidase 2, POTASSIUM ION | | Authors: | Reddi, R, Gumpena, R, Kishor, C, Addlagatta, A. | | Deposit date: | 2012-12-13 | | Release date: | 2013-12-18 | | Last modified: | 2019-11-20 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Selective targeting of the conserved active site cysteine of Mycobacterium tuberculosis methionine aminopeptidase with electrophilic reagents
Febs J., 281, 2014
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4IF7
 | | Mycobacterium Tuberculosis Methionine aminopeptidase Type 1c in complex with homocysteine-methyl disulfide | | Descriptor: | (2S)-2-amino-4-(methyldisulfanyl)butanoic acid, COBALT (II) ION, Methionine aminopeptidase 2 | | Authors: | Reddi, R, Gumpena, R, Kishor, C, Addlagatta, A. | | Deposit date: | 2012-12-14 | | Release date: | 2013-12-18 | | Last modified: | 2019-11-20 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Selective targeting of the conserved active site cysteine of Mycobacterium tuberculosis methionine aminopeptidase with electrophilic reagents
Febs J., 281, 2014
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4IDY
 | | Mycobacterium Tuberculosis Methionine aminopeptidase Type 1c in complex with 2-hydroxyethyl disulfide | | Descriptor: | 2-HYDROXYETHYL DISULFIDE, Methionine aminopeptidase 2, POTASSIUM ION | | Authors: | Reddi, R, Gumpena, R, Kishor, C, Addlagatta, A. | | Deposit date: | 2012-12-13 | | Release date: | 2013-12-18 | | Last modified: | 2015-02-04 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Selective targeting of the conserved active site cysteine of Mycobacterium tuberculosis methionine aminopeptidase with electrophilic reagents
Febs J., 281, 2014
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4KM3
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5ZI7
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