7BU5
| Crystal Structure of Human SLX4 and MUS81 | Descriptor: | GLYCINE, MUS81 endonuclease homolog (Yeast), isoform CRA_b, ... | Authors: | Wan, B, Wu, J, Lei, M. | Deposit date: | 2020-04-04 | Release date: | 2021-04-07 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | SLX4 control MUS81 endonuclease function in telomere through an intermolecular SAP domain To be published
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4ZOU
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4M7C
| Crystal structure of the TRF2-binding motif of SLX4 in complex with the TRFH domain of TRF2 | Descriptor: | Peptide from Structure-specific endonuclease subunit SLX4, Telomeric repeat-binding factor 2 | Authors: | Wan, B, Chen, Y, Wu, J, Liu, Y, Lei, M. | Deposit date: | 2013-08-12 | Release date: | 2013-09-25 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | SLX4 Assembles a Telomere Maintenance Toolkit by Bridging Multiple Endonucleases with Telomeres Cell Rep, 4, 2013
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5DOF
| Crystal structure of Tetrahymena p19 | Descriptor: | Telomerase-associated protein 19 | Authors: | Wan, B, Tang, T, Wu, J, Lei, M. | Deposit date: | 2015-09-11 | Release date: | 2015-11-25 | Last modified: | 2015-12-23 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The Tetrahymena telomerase p75-p45-p19 subcomplex is a unique CST complex. Nat.Struct.Mol.Biol., 22, 2015
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5DOI
| Crystal structure of Tetrahymena p45N and p19 | Descriptor: | Telomerase associated protein p45, Telomerase-associated protein 19 | Authors: | Wan, B, Tang, T, Wu, J, Lei, M. | Deposit date: | 2015-09-11 | Release date: | 2015-11-25 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The Tetrahymena telomerase p75-p45-p19 subcomplex is a unique CST complex Nat.Struct.Mol.Biol., 22, 2015
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5DOK
| Crystal structure of Tetrahymena p45C | Descriptor: | MAGNESIUM ION, Telomerase associated protein p45 | Authors: | Wan, B, Tang, T, Wu, J, Lei, M. | Deposit date: | 2015-09-11 | Release date: | 2015-11-25 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The Tetrahymena telomerase p75-p45-p19 subcomplex is a unique CST complex Nat.Struct.Mol.Biol., 22, 2015
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6J0W
| Crystal Structure of Yeast Rtt107 and Nse6 | Descriptor: | Peptide from DNA repair protein KRE29, Regulator of Ty1 transposition protein 107 | Authors: | Wan, B, Wu, J, Lei, M. | Deposit date: | 2018-12-27 | Release date: | 2019-08-14 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Molecular Basis for Control of Diverse Genome Stability Factors by the Multi-BRCT Scaffold Rtt107. Mol.Cell, 75, 2019
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6J0V
| Crystal Structure of Yeast Rtt107 | Descriptor: | Regulator of Ty1 transposition protein 107 | Authors: | Wan, B, Wu, J, Lei, M. | Deposit date: | 2018-12-27 | Release date: | 2019-08-14 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.314 Å) | Cite: | Molecular Basis for Control of Diverse Genome Stability Factors by the Multi-BRCT Scaffold Rtt107. Mol.Cell, 75, 2019
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6J0Y
| Crystal Structure of Yeast Rtt107 and Slx4 | Descriptor: | Peptide from Structure-specific endonuclease subunit SLX4, Regulator of Ty1 transposition protein 107 | Authors: | Wan, B, Wu, J, Lei, M. | Deposit date: | 2018-12-27 | Release date: | 2019-08-14 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Molecular Basis for Control of Diverse Genome Stability Factors by the Multi-BRCT Scaffold Rtt107. Mol.Cell, 75, 2019
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6J0X
| Crystal Structure of Yeast Rtt107 and Mms22 | Descriptor: | Peptide from E3 ubiquitin-protein ligase substrate receptor MMS22, Regulator of Ty1 transposition protein 107 | Authors: | Wan, B, Wu, J, Lei, M. | Deposit date: | 2018-12-27 | Release date: | 2019-08-14 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Molecular Basis for Control of Diverse Genome Stability Factors by the Multi-BRCT Scaffold Rtt107. Mol.Cell, 75, 2019
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3U88
| Crystal structure of human menin in complex with MLL1 and LEDGF | Descriptor: | (4beta,8alpha,9R)-6'-methoxy-10,11-dihydrocinchonan-9-ol, CHOLIC ACID, GLYOXYLIC ACID, ... | Authors: | Huang, J, Wan, B, Lei, M. | Deposit date: | 2011-10-16 | Release date: | 2012-02-15 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | The same pocket in menin binds both MLL and JUND but has opposite effects on transcription. Nature, 482, 2012
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3U84
| Crystal Structure of Human Menin | Descriptor: | Menin | Authors: | Huang, J, Wan, B, Lei, M. | Deposit date: | 2011-10-15 | Release date: | 2012-02-15 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The same pocket in menin binds both MLL and JUND but has opposite effects on transcription. Nature, 482, 2012
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3TOJ
| Structure of the SPRY domain of human Ash2L | Descriptor: | Set1/Ash2 histone methyltransferase complex subunit ASH2 | Authors: | Chen, Y, Cao, F, Wan, B, Dou, Y, Lei, M. | Deposit date: | 2011-09-05 | Release date: | 2012-01-25 | Last modified: | 2017-08-23 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | Structure of the SPRY domain of human Ash2L and its interactions with RbBP5 and DPY30. Cell Res., 22, 2012
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3U85
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3U86
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3RSN
| Crystal Structure of the N-terminal region of Human Ash2L | Descriptor: | Set1/Ash2 histone methyltransferase complex subunit ASH2, ZINC ION | Authors: | Chen, Y, Wan, B, Wang, K.C, Cao, F, Yang, Y, Protacio, A, Dou, Y, Chang, H.Y, Lei, M. | Deposit date: | 2011-05-02 | Release date: | 2011-06-22 | Last modified: | 2011-12-14 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of the N-terminal region of human Ash2L shows a winged-helix motif involved in DNA binding. Embo Rep., 12, 2011
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7YTJ
| Cryo-EM structure of VTC complex | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, INOSITOL HEXAKISPHOSPHATE, PHOSPHATE ION, ... | Authors: | Guan, Z.Y, Chen, J, Liu, R.W, Chen, Y.K, Xing, Q, Du, Z.M, Liu, Z. | Deposit date: | 2022-08-15 | Release date: | 2023-02-22 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | The cytoplasmic synthesis and coupled membrane translocation of eukaryotic polyphosphate by signal-activated VTC complex. Nat Commun, 14, 2023
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7RRD
| IDO1 IN COMPLEX WITH COMPOUND S-1 | Descriptor: | 3-[4-(1H-benzimidazol-2-yl)phenyl]-N-(4-fluorophenyl)oxetane-3-carboxamide, Indoleamine 2,3-dioxygenase 1 | Authors: | Lesburg, C.A. | Deposit date: | 2021-08-09 | Release date: | 2022-08-24 | Method: | X-RAY DIFFRACTION (2.76 Å) | Cite: | Oxetane promise delivered: discovery of long acting IDO1 inhibitors suitable for Q3W oral or parenteral dosing To Be Published
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7RRC
| IDO1 IN COMPLEX WITH COMPOUND 14 | Descriptor: | Indoleamine 2,3-dioxygenase 1, N-(4-fluorophenyl)-3-{4-[4-(hydroxymethyl)-6-(trifluoromethyl)pyridin-3-yl]phenyl}oxetane-3-carboxamide | Authors: | Lesburg, C.A. | Deposit date: | 2021-08-09 | Release date: | 2022-03-16 | Last modified: | 2022-05-11 | Method: | X-RAY DIFFRACTION (2.18 Å) | Cite: | Oxetane Promise Delivered: Discovery of Long-Acting IDO1 Inhibitors Suitable for Q3W Oral or Parenteral Dosing. J.Med.Chem., 65, 2022
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7RRB
| IDO1 IN COMPLEX WITH COMPOUND 9 | Descriptor: | 3-[4-(6-cyclopropylpyridin-3-yl)phenyl]-N-(4-fluorophenyl)oxetane-3-carboxamide, Indoleamine 2,3-dioxygenase 1 | Authors: | Lesburg, C.A. | Deposit date: | 2021-08-09 | Release date: | 2022-03-16 | Last modified: | 2022-05-11 | Method: | X-RAY DIFFRACTION (2.69 Å) | Cite: | Oxetane Promise Delivered: Discovery of Long-Acting IDO1 Inhibitors Suitable for Q3W Oral or Parenteral Dosing. J.Med.Chem., 65, 2022
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7LTO
| Nse5-6 complex | Descriptor: | Non-structural maintenance of chromosome element 5, Ubiquitin-like protein SMT3,DNA repair protein KRE29 chimera | Authors: | Yu, Y, Li, S.B, Zheng, S, Tangy, S, Koyi, C, Wan, B.B, Kung, H.H, Andrej, S, Alex, K, Patel, D.J, Zhao, X.L. | Deposit date: | 2021-02-19 | Release date: | 2021-05-19 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Integrative analysis reveals unique structural and functional features of the Smc5/6 complex. Proc.Natl.Acad.Sci.USA, 118, 2021
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5AGT
| Crystal structure of the LeuRS editing domain of Mycobacterium tuberculosis in complex with the adduct (S)-3-(Aminomethyl)-4-chloro-7-ethoxybenzo[c][1,2]oxaborol-1(3H)-ol-AMP | Descriptor: | 4-Chloro-3-aminomethyl-7-[ethoxy]-3H-benzo[C][1,2]oxaborol-1-ol modified adenosine, GLYCEROL, LEUCINE--TRNA LIGASE, ... | Authors: | Palencia, A, Li, X, Alley, M.R.K, Ding, C, Easom, E.E, Hernandez, V, Meewan, M, Mohan, M, Rock, F.L, Franzblau, S.G, Wang, Y, Lenaerts, A.J, Parish, T, Cooper, C.B, Waters, M.G, Ma, Z, Mendoza, A, Barros, D, Cusack, S, Plattner, J.J. | Deposit date: | 2015-02-03 | Release date: | 2016-03-02 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium Tuberculosis that Target Leucyl-tRNA Synthetase. Antimicrob.Agents Chemother., 60, 2016
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5AGS
| Crystal structure of the LeuRS editing domain of Mycobacterium tuberculosis in complex with the adduct 3-(Aminomethyl)-4-bromo-7-ethoxybenzo[c][1,2]oxaborol-1(3H)-ol-AMP | Descriptor: | 3-(AMINOMETHYL)-4-BROMO-7-ETHOXYBENZO[C][1,2]OXABOROL-1(3H)-OL-MODIFIED ADENOSINE, LEUCYL-TRNA SYNTHETASE, METHIONINE | Authors: | Palencia, A, Li, X, Alley, M.R.K, Ding, C, Easom, E.E, Hernandez, V, Meewan, M, Mohan, M, Rock, F.L, Franzblau, S.G, Wang, Y, Lenaerts, A.J, Parish, T, Cooper, C.B, Waters, M.G, Ma, Z, Mendoza, A, Barros, D, Cusack, S, Plattner, J.J. | Deposit date: | 2015-02-03 | Release date: | 2016-03-09 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.47 Å) | Cite: | Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium Tuberculosis that Target Leucyl-tRNA Synthetase. Antimicrob.Agents Chemother., 60, 2016
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5AGR
| Crystal structure of the LeuRS editing domain of Mycobacterium tuberculosis in complex with the adduct (S)-3-(Aminomethyl)-7-ethoxybenzo[c][1,2]oxaborol-1(3H)-ol-AMP | Descriptor: | 1,2-ETHANEDIOL, 3-AMINOMETHYL-7-(ETHOXY)-3H-BENZO[C][1,2]OXABOROL-1-OL modified adenosine, LEUCINE, ... | Authors: | Palencia, A, Li, X, Alley, M.R.K, Ding, C, Easom, E.E, Hernandez, V, Meewan, M, Mohan, M, Rock, F.L, Franzblau, S.G, Wang, Y, Lenaerts, A.J, Parish, T, Cooper, C.B, Waters, M.G, Ma, Z, Mendoza, A, Barros, D, Cusack, S, Plattner, J.J. | Deposit date: | 2015-02-03 | Release date: | 2016-03-02 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium Tuberculosis that Target Leucyl-tRNA Synthetase. Antimicrob.Agents Chemother., 60, 2016
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4DNC
| Crystal structure of human MOF in complex with MSL1 | Descriptor: | Histone acetyltransferase KAT8, Male-specific lethal 1 homolog, ZINC ION | Authors: | Huang, J, Lei, M. | Deposit date: | 2012-02-08 | Release date: | 2012-07-25 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Structural insight into the regulation of MOF in the male-specific lethal complex and the non-specific lethal complex. Cell Res., 22, 2012
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