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3WBB
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BU of 3wbb by Molmil
Crystal Structures of meso-diaminopimelate dehydrogenase from Symbiobacterium thermophilum
Descriptor: Diaminopimelate dehydrogenase, GLYCEROL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Liu, W.D, Li, Z, Huang, C.H, Guo, R.T, Wu, Q.Q, Zhu, D.M.
Deposit date:2013-05-14
Release date:2014-03-26
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Structural and mutational studies on the unusual substrate specificity of meso-diaminopimelate dehydrogenase from Symbiobacterium thermophilum.
Chembiochem, 15, 2014
3NSM
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BU of 3nsm by Molmil
Crystal Structure of insect beta-N-acetyl-D-hexosaminidase OfHex1 from Ostrinia furnacalis
Descriptor: N-acetylglucosaminidase
Authors:Zhang, H, Liu, T, Liu, F, Yang, Q, Shen, X.
Deposit date:2010-07-02
Release date:2010-11-24
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Determinants of an Insect {beta}-N-Acetyl-D-hexosaminidase Specialized as a Chitinolytic Enzyme
J.Biol.Chem., 286, 2011
6KZP
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BU of 6kzp by Molmil
calcium channel-ligand
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Yan, N.
Deposit date:2019-09-25
Release date:2019-12-18
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Cryo-EM structures of apo and antagonist-bound human Cav3.1.
Nature, 576, 2019
6KZO
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BU of 6kzo by Molmil
membrane protein
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Yan, N.
Deposit date:2019-09-25
Release date:2019-12-18
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Cryo-EM structures of apo and antagonist-bound human Cav3.1.
Nature, 576, 2019
6MT0
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BU of 6mt0 by Molmil
Crystal structure of human Pim-1 kinase in complex with a quinazolinone-pyrrolodihydropyrrolone inhibitor
Descriptor: 3-(1-methylcyclopropyl)-2-[(1-methylcyclopropyl)amino]-8-[(6R)-6-methyl-4-oxo-1,4,5,6-tetrahydropyrrolo[3,4-b]pyrrol-2-yl]quinazolin-4(3H)-one, GLYCEROL, Serine/threonine-protein kinase pim-1
Authors:Mohr, C.
Deposit date:2018-10-18
Release date:2019-01-16
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Discovery of ( R)-8-(6-Methyl-4-oxo-1,4,5,6-tetrahydropyrrolo[3,4- b]pyrrol-2-yl)-3-(1-methylcyclopropyl)-2-((1-methylcyclopropyl)amino)quinazolin-4(3 H)-one, a Potent and Selective Pim-1/2 Kinase Inhibitor for Hematological Malignancies.
J. Med. Chem., 62, 2019
5K0M
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BU of 5k0m by Molmil
Targeting the PRC2 complex through a novel protein-protein interaction inhibitor of EED
Descriptor: (3R,4S)-1-[(1S)-7-fluoro-2,3-dihydro-1H-inden-1-yl]-N,N-dimethyl-4-{4-[4-(methylsulfonyl)piperazin-1-yl]phenyl}pyrrolidin-3-amine, Polycomb protein EED
Authors:Jakob, C.G, Bigelow, L.J, Zhu, H, Sun, C.
Deposit date:2016-05-17
Release date:2017-01-25
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex.
Nat. Chem. Biol., 13, 2017
5EOL
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BU of 5eol by Molmil
Crystal structure of human Pim-1 kinase in complex with a macrocyclic quinoxaline-pyrrolodihydropiperidinone inhibitor
Descriptor: GLYCEROL, Serine/threonine-protein kinase pim-1, macrocyclic quinoxaline-pyrrolodihydropiperidinone
Authors:Mohr, C.
Deposit date:2015-11-10
Release date:2016-05-04
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Discovery and Optimization of Macrocyclic Quinoxaline-pyrrolo-dihydropiperidinones as Potent Pim-1/2 Kinase Inhibitors.
Acs Med.Chem.Lett., 7, 2016
7BTN
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BU of 7btn by Molmil
Crystal structure of human inorganic pyrophosphatase with metal ions
Descriptor: Inorganic pyrophosphatase, MAGNESIUM ION
Authors:Hu, F, Huang, Z, Li, L.
Deposit date:2020-04-02
Release date:2020-10-21
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.382 Å)
Cite:Structural and biochemical characterization of inorganic pyrophosphatase from Homo sapiens.
Biochem.Biophys.Res.Commun., 533, 2020
6M53
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BU of 6m53 by Molmil
Crystal structure of 2, 3-dihydroxybenzoic acid decarboxylase from Fusarium oxysporum
Descriptor: 2,3-dihydroxybenzoate decarboxylase, GLYCEROL, ZINC ION
Authors:Song, M.K, Feng, J.H, Liu, W.D, Wu, Q.Q, Zhu, D.M.
Deposit date:2020-03-09
Release date:2020-07-15
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:2,3-Dihydroxybenzoic Acid Decarboxylase from Fusarium oxysporum: Crystal Structures and Substrate Recognition Mechanism.
Chembiochem, 21, 2020
4I5S
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BU of 4i5s by Molmil
Structure and function of sensor histidine kinase
Descriptor: Putative histidine kinase CovS; VicK-like protein
Authors:Cai, Y.
Deposit date:2012-11-28
Release date:2013-03-27
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Mechanistic insights revealed by the crystal structure of a histidine kinase with signal transducer and sensor domains
Plos Biol., 11, 2013
1I51
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BU of 1i51 by Molmil
CRYSTAL STRUCTURE OF CASPASE-7 COMPLEXED WITH XIAP
Descriptor: CASPASE-7 SUBUNIT P11, CASPASE-7 SUBUNIT P20, X-LINKED INHIBITOR OF APOPTOSIS PROTEIN
Authors:Chai, J, Shi, Y.
Deposit date:2001-02-23
Release date:2002-02-23
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structural basis of caspase-7 inhibition by XIAP.
Cell(Cambridge,Mass.), 104, 2001
7MK2
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BU of 7mk2 by Molmil
CryoEM Structure of NPR1
Descriptor: Regulatory protein NPR1, ZINC ION
Authors:Kumar, S, Zhou, Y, Dillard, L, Borgnia, M, Bartesaghi, A, Zhou, P.
Deposit date:2021-04-21
Release date:2022-03-16
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structural basis of NPR1 in activating plant immunity.
Nature, 605, 2022
7R7I
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BU of 7r7i by Molmil
Structure of human SHP2 in complex with compound 27
Descriptor: Tyrosine-protein phosphatase non-receptor type 11, [3-(4-amino-4-methylpiperidin-1-yl)-6-(2,3-dichlorophenyl)-5-methylpyrazin-2-yl]methanol
Authors:Leonard, P.G, Cross, J.
Deposit date:2021-06-24
Release date:2021-10-27
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Discovery of 6-[(3 S ,4 S )-4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methyl-3,4-dihydropyrimidin-4-one (IACS-15414), a Potent and Orally Bioavailable SHP2 Inhibitor.
J.Med.Chem., 64, 2021
7R75
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BU of 7r75 by Molmil
Structure of human SHP2 in complex with compound 16
Descriptor: 6-(4-amino-4-methylpiperidin-1-yl)-3-(3-chlorophenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, Tyrosine-protein phosphatase non-receptor type 11
Authors:Leonard, P.G, Cross, J.
Deposit date:2021-06-24
Release date:2021-10-27
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.83 Å)
Cite:Discovery of 6-[(3 S ,4 S )-4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methyl-3,4-dihydropyrimidin-4-one (IACS-15414), a Potent and Orally Bioavailable SHP2 Inhibitor.
J.Med.Chem., 64, 2021
7R7D
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BU of 7r7d by Molmil
Structure of human SHP2 in complex with compound 22
Descriptor: 4-[6-(4-amino-4-methylpiperidin-1-yl)-1H-pyrazolo[3,4-b]pyrazin-3-yl]-3-chloro-N-methylpyridin-2-amine, TETRAETHYLENE GLYCOL, Tyrosine-protein phosphatase non-receptor type 11
Authors:Leonard, P.G, Cross, J.
Deposit date:2021-06-24
Release date:2021-10-27
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Discovery of 6-[(3 S ,4 S )-4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methyl-3,4-dihydropyrimidin-4-one (IACS-15414), a Potent and Orally Bioavailable SHP2 Inhibitor.
J.Med.Chem., 64, 2021
7R7L
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BU of 7r7l by Molmil
Structure of human SHP2 in complex with compound 30
Descriptor: 6-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methylpyrimidin-4(3H)-one, Tyrosine-protein phosphatase non-receptor type 11
Authors:Leonard, P.G, Cross, J.
Deposit date:2021-06-24
Release date:2021-10-27
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3 Å)
Cite:Discovery of 6-[(3 S ,4 S )-4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methyl-3,4-dihydropyrimidin-4-one (IACS-15414), a Potent and Orally Bioavailable SHP2 Inhibitor.
J.Med.Chem., 64, 2021
3WTD
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BU of 3wtd by Molmil
Structure of PAXX
Descriptor: Uncharacterized protein C9orf142
Authors:Ochi, T, Blundell, T.L.
Deposit date:2014-04-09
Release date:2015-01-21
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:DNA repair. PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair.
Science, 347, 2015
3WTF
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BU of 3wtf by Molmil
Structure of PAXX
Descriptor: Uncharacterized protein C9orf142
Authors:Ochi, T, Blundell, T.L.
Deposit date:2014-04-09
Release date:2015-01-21
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.451 Å)
Cite:DNA repair. PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair.
Science, 347, 2015
8JQK
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BU of 8jqk by Molmil
Crystal structure of a carbonyl reductase SSCR mutant from Sporobolomyces Salmonicolor
Descriptor: Aldehyde reductase 2
Authors:Zhang, H.L, Li, Q, Liu, W.D, Chen, X, Wu, Q.Q, Zhu, D.M.
Deposit date:2023-06-14
Release date:2023-12-27
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Engineering a Carbonyl Reductase to Simultaneously Increase Activity Toward Bulky Ketone and Isopropanol for Dynamic Kinetic Asymmetric Reduction via Enzymatic Hydrogen Transfer
Acs Catalysis, 13, 2023
8JQJ
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BU of 8jqj by Molmil
Crystal structure of carbonyl reductase SSCR mutant 1 from Sporobolomyces Salmonicolor
Descriptor: Aldehyde reductase 2
Authors:Zhang, H.L, Li, Q, Liu, W.D, Chen, X, Wu, Q.Q, Zhu, D.M.
Deposit date:2023-06-14
Release date:2023-12-27
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Engineering a Carbonyl Reductase to Simultaneously Increase Activity Toward Bulky Ketone and Isopropanol for Dynamic Kinetic Asymmetric Reduction via Enzymatic Hydrogen Transfer
Acs Catalysis, 13, 2023
7TAE
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BU of 7tae by Molmil
Crystal Structure of the NPR1-Interacting Domain of TGA3
Descriptor: GLYCEROL, PALMITIC ACID, Transcription factor TGA3
Authors:Cheng, J, Zhou, P.
Deposit date:2021-12-20
Release date:2022-03-16
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural basis of NPR1 in activating plant immunity.
Nature, 605, 2022
4ZMD
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BU of 4zmd by Molmil
C domain of staphylococcal protein A mutant - Q9W
Descriptor: Immunoglobulin G-binding protein A
Authors:Deis, L.N, Oas, T.G.
Deposit date:2015-05-03
Release date:2015-07-15
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Suppression of conformational heterogeneity at a protein-protein interface.
Proc.Natl.Acad.Sci.USA, 112, 2015
4ZNC
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BU of 4znc by Molmil
Fc fragment of human IgG in complex with the C domain of staphylococcal protein A mutant - Q9W
Descriptor: Ig gamma-3 chain C region, Immunoglobulin G-binding protein A
Authors:Deis, L.N, Oas, T.G.
Deposit date:2015-05-04
Release date:2015-07-15
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Suppression of conformational heterogeneity at a protein-protein interface.
Proc.Natl.Acad.Sci.USA, 112, 2015
4YRV
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BU of 4yrv by Molmil
Crystal structure of Anabaena transcription factor HetR complexed with 21-bp DNA from hetP promoter
Descriptor: CALCIUM ION, DNA (5'-D(P*AP*TP*GP*AP*GP*GP*GP*GP*TP*TP*AP*GP*AP*CP*CP*CP*CP*TP*CP*GP*C)-3'), DNA (5'-D(P*GP*CP*GP*AP*GP*GP*GP*GP*TP*CP*TP*AP*AP*CP*CP*CP*CP*TP*CP*AP*T)-3'), ...
Authors:Hu, H.X, Jiang, Y.L, Zhao, M.X, Zhang, C.C, Chen, Y, Zhou, C.Z.
Deposit date:2015-03-16
Release date:2015-12-02
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural insights into HetR-PatS interaction involved in cyanobacterial pattern formation
Sci Rep, 5, 2015
4ZXT
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BU of 4zxt by Molmil
Complex of ERK2 with catechol
Descriptor: AMMONIUM ION, CATECHOL, Mitogen-activated protein kinase 1, ...
Authors:Kurinov, I, Malakhova, M.
Deposit date:2015-05-20
Release date:2016-05-25
Last modified:2016-10-05
Method:X-RAY DIFFRACTION (2 Å)
Cite:A natural small molecule, catechol, induces c-Myc degradation by directly targeting ERK2 in lung cancer.
Oncotarget, 7, 2016

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