1SYL
| Crystal structure of inactive mutant dUTPase complexed with substrate dUTP | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DEOXYURIDINE-5'-TRIPHOSPHATE, Deoxyuridine 5'-triphosphate nucleotidohydrolase, ... | Authors: | Barabas, O, Kovari, J, Pongracz, V, Wilmanns, M, Vertessy, B.G. | Deposit date: | 2004-04-01 | Release date: | 2004-09-07 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural Insights into the Catalytic Mechanism of Phosphate Ester Hydrolysis by dUTPase J.Biol.Chem., 279, 2004
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3TQ5
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2PY4
| Full length structure of the Mycobacterium tuberculosis dUTPase complexed with magnesium and alpha,beta-imido-dUTP. | Descriptor: | 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Deoxyuridine 5'-triphosphate nucleotidohydrolase, ... | Authors: | Barabas, O, Nagy, N, Takacs, E, Vertessy, B.G. | Deposit date: | 2007-05-15 | Release date: | 2007-05-22 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.49 Å) | Cite: | Active site of mycobacterial dUTPase: structural characteristics and a built-in sensor. Biochem.Biophys.Res.Commun., 373, 2008
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2HQU
| Human dUTPase in complex with alpha,beta-iminodUTP and magnesium ion | Descriptor: | 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, CHLORIDE ION, Deoxyuridine 5'-triphosphate nucleotidohydrolase, ... | Authors: | Barabas, O, Varga, B, Vertessy, B.G. | Deposit date: | 2006-07-19 | Release date: | 2007-07-24 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Active site closure facilitates juxtaposition of reactant atoms for initiation of catalysis by human dUTPase. Febs Lett., 581, 2007
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1RNJ
| Crystal structure of inactive mutant dUTPase complexed with substrate analogue imido-dUTP | Descriptor: | 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Deoxyuridine 5'-triphosphate nucleotidohydrolase, ... | Authors: | Barabas, O, Pongracz, V, Kovari, J, Wilmanns, M, Vertessy, B.G. | Deposit date: | 2003-12-01 | Release date: | 2004-09-07 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural Insights into the Catalytic Mechanism of Phosphate Ester Hydrolysis by dUTPase. J.Biol.Chem., 279, 2004
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3IF7
| Structure of Calmodulin complexed with its first endogenous inhibitor, sphingosylphosphorylcholine | Descriptor: | 2-{[(R)-{[(2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl]oxy}(hydroxy)phosphoryl]oxy}-N,N,N-trimethylethanaminium, CALCIUM ION, Calmodulin | Authors: | Kovacs, E, Harmat, V, Toth, J, Vertessy, B.G, Modos, K, Kardos, J, Liliom, K. | Deposit date: | 2009-07-24 | Release date: | 2010-06-30 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structure and mechanism of calmodulin binding to a signaling sphingolipid reveal new aspects of lipid-protein interactions Faseb J., 24, 2010
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3I93
| Crystal structure of Mycobacterium tuberculosis dUTPase STOP138T mutant | Descriptor: | 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Deoxyuridine 5'-triphosphate nucleotidohydrolase, ... | Authors: | Leveles, I, Harmat, V, Lopata, A, Toth, J, Vertessy, B.G. | Deposit date: | 2009-07-10 | Release date: | 2009-11-24 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Direct contacts between conserved motifs of different subunits provide major contribution to active site organization in human and mycobacterial dUTPases. Febs Lett., 584, 2010
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3HZA
| Crystal structure of dUTPase H145W mutant | Descriptor: | 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Deoxyuridine 5'-triphosphate nucleotidohydrolase, ... | Authors: | Leveles, I, Harmat, V, Pecsi, I, Toth, J, Vertessy, B.G. | Deposit date: | 2009-06-23 | Release date: | 2009-11-24 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Aromatic stacking between nucleobase and enzyme promotes phosphate ester hydrolysis in dUTPase. Nucleic Acids Res., 38, 2010
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3H6D
| Structure of the mycobacterium tuberculosis DUTPase D28N mutant | Descriptor: | 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Deoxyuridine 5'-triphosphate nucleotidohydrolase, ... | Authors: | Leveles, I, Harmat, V, Nagy, G, Takacs, E, Lopata, A, Toth, J, Vertessy, B.G. | Deposit date: | 2009-04-23 | Release date: | 2009-11-24 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Direct contacts between conserved motifs of different subunits provide major contribution to active site organization in human and mycobacterial dUTPases. Febs Lett., 584, 2010
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3BLY
| Pyranose 2-oxidase from Trametes multicolor, E542K/L537W | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, FLAVIN-ADENINE DINUCLEOTIDE, Pyranose oxidase | Authors: | Tan, T.C, Divne, C. | Deposit date: | 2007-12-11 | Release date: | 2008-12-02 | Last modified: | 2021-11-10 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Improving thermostability and catalytic activity of pyranose 2-oxidase from Trametes multicolor by rational and semi-rational design Febs J., 276, 2009
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6F6T
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6H2O
| APO structure of Phenylalanine ammonia-lyase from Petroselinum crispum | Descriptor: | Phenylalanine ammonia-lyase 1 | Authors: | Molnar, B, Bata, Z, Leveles, I, Poppe, L, Vertessy, G.B. | Deposit date: | 2018-07-14 | Release date: | 2019-07-31 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Substrate Tunnel Engineering Aided by X-ray Crystallography and Functional Dynamics Swaps the Function of MIO-Enzymes Acs Catalysis, 2021
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6HQF
| Structure of Phenylalanine ammonia-lyase from Petroselinum crispum in complex with (R)-APEP | Descriptor: | Phenylalanine ammonia-lyase 1, [(1R)-1-amino-2-phenylethyl]phosphonic acid | Authors: | Bata, Z, Molnar, B, Leveles, I, Poppe, L, Vertessy, G.B. | Deposit date: | 2018-09-24 | Release date: | 2019-10-09 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Substrate Tunnel Engineering Aided by X-ray Crystallography and Functional Dynamics Swaps the Function of MIO-Enzymes Acs Catalysis, 2021
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3TRN
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3TPN
| Crystal structure of M-PMV dUTPASE complexed with dUPNPP, substrate | Descriptor: | 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | Authors: | Nemeth, V, Barabas, O, Vertessy, G.B. | Deposit date: | 2011-09-08 | Release date: | 2011-10-12 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Structural Snapshots of Enzyme-Catalysed Phosphate Ester Hydrolysis Directly Visualize In-line Attack and Inversion To be Published
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3TS6
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3TTA
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3TSL
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5ECT
| Mycobacterium tuberculosis dUTPase G143STOP mutant | Descriptor: | 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Deoxyuridine 5'-triphosphate nucleotidohydrolase, ... | Authors: | Nagy, G.N, Leveles, I, Harmat, V, Vertessy, G.B. | Deposit date: | 2015-10-20 | Release date: | 2016-11-02 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Structural Characterization of Arginine Fingers: Identification of an Arginine Finger for the Pyrophosphatase dUTPases. J. Am. Chem. Soc., 138, 2016
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5EDD
| Crystal structure of Mycobacterium tuberculosis dUTPase R140K, H145W mutant | Descriptor: | 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Deoxyuridine 5'-triphosphate nucleotidohydrolase, ... | Authors: | Nagy, G.N, Leveles, I, Lopata, A, Harmat, V, Toth, J, Vertessy, G.B. | Deposit date: | 2015-10-21 | Release date: | 2016-11-02 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | Structural Characterization of Arginine Fingers: Identification of an Arginine Finger for the Pyrophosphatase dUTPases. J. Am. Chem. Soc., 138, 2016
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2D4N
| Crystal Structure of M-PMV dUTPase complexed with dUPNPP, substrate analogue | Descriptor: | 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DU, ... | Authors: | Nemeth, V, Barabas, O, Vertessy, G.B. | Deposit date: | 2005-10-20 | Release date: | 2006-11-21 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.53 Å) | Cite: | Flexible segments modulate co-folding of dUTPase and nucleocapsid proteins. Nucleic Acids Res., 35, 2007
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2D4M
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2D4L
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3BG6
| Pyranose 2-oxidase from Trametes multicolor, E542K mutant | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Pyranose oxidase | Authors: | Tan, T.C, Divne, C. | Deposit date: | 2007-11-26 | Release date: | 2008-12-02 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Improving thermostability and catalytic activity of pyranose 2-oxidase from Trametes multicolor by rational and semi-rational design Febs J., 276, 2009
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3BG7
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