8YBX

Structure of the FADD/Caspase-8/cFLIP death effector domain assembly

Summary for 8YBX

• Entry DOI: 10.2210/pdb8ybx/pdb
• EMDB information: 39126
• Descriptor: Caspase-8 subunit p10, CASP8 and FADD-like apoptosis regulator subunit p43, FAS-associated death domain protein (3 entities in total)
• Functional Keywords: fadd, caspase-8, cellular flice-like inhibitory protein, death effector domain, apoptosis
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 10
• Total formula weight: 322233.46

Authors

Lin, S.-C.,Yang, C.-Y. (deposition date: 2024-02-16, release date: 2024-05-15)

• Primary citation: Yang, C.Y.,Lien, C.I.,Tseng, Y.C.,Tu, Y.F.,Kulczyk, A.W.,Lu, Y.C.,Wang, Y.T.,Su, T.W.,Hsu, L.C.,Lo, Y.C.,Lin, S.C.; Deciphering DED assembly mechanisms in FADD-procaspase-8-cFLIP complexes regulating apoptosis.; Nat Commun, 15:3791-3791, 2024; PubMed: 38710704; DOI: 10.1038/s41467-024-47990-2

Experimental method

ELECTRON MICROSCOPY (3.68 Å)