8WG8

Cryo-EM structures of peptide free and Gs-coupled GCGR

Summary for 8WG8

• Entry DOI: 10.2210/pdb8wg8/pdb
• EMDB information: 37505
• Descriptor: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• Functional Keywords: g protein-coupled receptor, ligand recognition, receptor activation, unimolecular agonist, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 153980.30

Authors

Cong, Z.T.,Zhao, F.H.,Li, Y.,Luo, G.,Zhou, Q.T.,Yang, D.H.,Wang, M.W. (deposition date: 2023-09-20, release date: 2024-03-06)

• Primary citation: Cong, Z.,Zhao, F.,Li, Y.,Luo, G.,Mai, Y.,Chen, X.,Chen, Y.,Lin, S.,Cai, X.,Zhou, Q.,Yang, D.,Wang, M.W.; Molecular features of the ligand-free GLP-1R, GCGR and GIPR in complex with G s proteins.; Cell Discov, 10:18-18, 2024; PubMed: 38346960; DOI: 10.1038/s41421-024-00649-0

Experimental method

ELECTRON MICROSCOPY (2.71 Å)