8WE3

Crystal structure of human FABP4 complexed with C7

Summary for 8WE3

• Entry DOI: 10.2210/pdb8we3/pdb
• Descriptor: Fatty acid-binding protein, adipocyte, 2-[(3-chloranyl-2-phenyl-phenyl)amino]-5-fluoranyl-benzoic acid (3 entities in total)
• Functional Keywords: lipid binding protein-inhibitor complex, lipid binding protein/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 17253.03

Authors

Xie, H.,Chen, G.F.,Xu, Y.C.,Li, M.J. (deposition date: 2023-09-16, release date: 2023-12-27)

• Primary citation: Chen, G.,Xie, H.,You, M.,Liu, J.,Shao, Q.,Li, M.,Su, H.,Xu, Y.; Structure-based design of potent FABP4 inhibitors with high selectivity against FABP3.; Eur.J.Med.Chem., 264:115984-115984, 2023; PubMed: 38043490; DOI: 10.1016/j.ejmech.2023.115984

Experimental method

X-RAY DIFFRACTION (1.82 Å)