8WA3

Cryo-EM structure of peptide free and Gs-coupled GIPR

Summary for 8WA3

Entry DOI	10.2210/pdb8wa3/pdb
EMDB information	37390
Descriptor	Gastric inhibitory polypeptide receptor,Fusion protein, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1,O-antigen polymerase, ... (5 entities in total)
Functional Keywords	glucose-dependent insulinotropic polypeptide receptor; cryo-electron microscopy; g protein-coupled receptor; ligand recognition, structural protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	5
Total formula weight	174125.29
Authors	Cong, Z.T.,Zhao, F.H.,Li, Y.,Luo, G.,Zhou, Q.T.,Yang, D.H.,Wang, M.W. (deposition date: 2023-09-06, release date: 2024-03-06)
Primary citation	Cong, Z.,Zhao, F.,Li, Y.,Luo, G.,Mai, Y.,Chen, X.,Chen, Y.,Lin, S.,Cai, X.,Zhou, Q.,Yang, D.,Wang, M.W. Molecular features of the ligand-free GLP-1R, GCGR and GIPR in complex with G s proteins. Cell Discov, 10:18-18, 2024 Cited by PubMed: 38346960 DOI: 10.1038/s41421-024-00649-0 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.86 Å)

Structure validation