8W6G

NaDC1 with inhibitor ACA

Summary for 8W6G

• Entry DOI: 10.2210/pdb8w6g/pdb
• EMDB information: 37322
• Descriptor: Solute carrier family 13 member 2, 2-[[(~{E})-3-(4-pentylphenyl)prop-2-enoyl]amino]benzoic acid, CHOLESTEROL HEMISUCCINATE, ... (4 entities in total)
• Functional Keywords: inhibitor, nadc1, transport protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 134926.77

Authors

Chi, X.,Chen, Y.,Li, Y.,Zhang, Y.,Shen, Y.,Chen, Y.,Wang, Z.,Yan, R. (deposition date: 2023-08-28, release date: 2024-04-17)

• Primary citation: Chi, X.,Chen, Y.,Li, Y.,Dai, L.,Zhang, Y.,Shen, Y.,Chen, Y.,Shi, T.,Yang, H.,Wang, Z.,Yan, R.; Cryo-EM structures of the human NaS1 and NaDC1 transporters revealed the elevator transport and allosteric regulation mechanism.; Sci Adv, 10:eadl3685-eadl3685, 2024; PubMed: 38552027; DOI: 10.1126/sciadv.adl3685

Experimental method

ELECTRON MICROSCOPY (3.3 Å)