8W3X

Crystal structure of IRAK4 in complex with compound 6

This is a non-PDB format compatible entry.

Summary for 8W3X

• Entry DOI: 10.2210/pdb8w3x/pdb
• Descriptor: Interleukin-1 receptor-associated kinase 4, 7-ethoxy-1-{[(2S)-5-oxopyrrolidin-2-yl]methoxy}isoquinoline-6-carboxamide (3 entities in total)
• Functional Keywords: interleukin-1 receptor-associated kinase 4, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 147653.48

Authors

Han, S.,Knafels, J.D. (deposition date: 2024-02-22, release date: 2024-05-01)

• Primary citation: Wright, S.W.,Farley, K.A.,Han, S.,Knafels, J.D.,Lee, K.L.; In Retrospect: Root-Cause Analysis of Structure-Activity Relationships in IRAK4 Inhibitor Zimlovisertib (PF-06650833).; Acs Med.Chem.Lett., 15:540-545, 2024; PubMed: 38628800; DOI: 10.1021/acsmedchemlett.4c00036

Experimental method

X-RAY DIFFRACTION (1.765 Å)