8VHM

Structure of DHODH in Complex with Fragment 2

This is a non-PDB format compatible entry.

Summary for 8VHM

• Entry DOI: 10.2210/pdb8vhm/pdb
• Descriptor: Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ... (8 entities in total)
• Functional Keywords: dhodh, oxidoreductase, inhibitor, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 41343.64

Authors

Shaffer, P.L. (deposition date: 2024-01-02, release date: 2024-04-03)

• Primary citation: DeRatt, L.G.,Pietsch, E.C.,Cisar, J.S.,Jacoby, E.,Kazmi, F.,Matico, R.,Shaffer, P.,Tanner, A.,Wang, W.,Attar, R.,Edwards, J.P.,Kuduk, S.D.; Discovery of Alternative Binding Poses through Fragment-Based Identification of DHODH Inhibitors.; Acs Med.Chem.Lett., 15:381-387, 2024; PubMed: 38505861; DOI: 10.1021/acsmedchemlett.3c00543

Experimental method

X-RAY DIFFRACTION (2.26 Å)