8VBV

Structure of the monofunctional Staphylococcus aureus PBP1 in its beta-lactam (Cephalexin) inhibited form

Summary for 8VBV

Entry DOI	10.2210/pdb8vbv/pdb
Descriptor	Penicillin-binding protein 1, (2S)-2-[(1R)-1-{[(2R)-2-amino-2-phenylacetyl]amino}-2-oxoethyl]-5-methyl-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid (3 entities in total)
Functional Keywords	penicillin binding protein 1, peptidoglycan transpeptidase domain, pedestal domain, membrane protein, hydrolase-inhibitor, antibiotic complex, hydrolase/inhibitor, antibiotic
Biological source	Staphylococcaceae bacterium
Total number of polymer chains	2
Total formula weight	133987.33
Authors	Bon, C.G.,Lee, J.,Caveney, N.A.,Strynadka, N.C.J. (deposition date: 2023-12-12, release date: 2024-05-01)
Primary citation	Bon, C.G.,Grigg, J.C.,Lee, J.,Robb, C.S.,Caveney, N.A.,Eltis, L.D.,Strynadka, N.C.J. Structural and kinetic analysis of the monofunctional Staphylococcus aureus PBP1. J.Struct.Biol., 216:108086-108086, 2024 Cited by PubMed: 38527711 DOI: 10.1016/j.jsb.2024.108086 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation