8V9M

Human Ornithine Aminotransferase cocrystallized with its inhibitor, (R)-3-amino-5,5-difluorocyclohex-1-ene-1-carboxylic acid.

Summary for 8V9M

Entry DOI	10.2210/pdb8v9m/pdb
Descriptor	Ornithine aminotransferase, mitochondrial, 3-fluoro-5-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]benzoic acid, GLYCEROL, ... (4 entities in total)
Functional Keywords	plp, ornithine aminotransferase, mechanism-based inactivator, heptocellular carcinoma, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	3
Total formula weight	136108.14
Authors	Vargas, A.L.,Devitt, A.,Kaley, N.,Silverman, R.,Liu, D. (deposition date: 2023-12-08, release date: 2024-05-08, Last modification date: 2024-05-29)
Primary citation	Devitt, A.N.,Vargas, A.L.,Zhu, W.,Des Soye, B.J.,Butun, F.A.,Alt, T.,Kaley, N.,Ferreira, G.M.,Moran, G.R.,Kelleher, N.L.,Liu, D.,Silverman, R.B. Design, Synthesis, and Mechanistic Studies of ( R )-3-Amino-5,5-difluorocyclohex-1-ene-1-carboxylic Acid as an Inactivator of Human Ornithine Aminotransferase. Acs Chem.Biol., 19:1066-1081, 2024 Cited by PubMed: 38630468 DOI: 10.1021/acschembio.4c00022 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.61 Å)

Structure validation